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name	prostaglandin-I synthase activity
Accession	GO
Definition	Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
Enzyme Classification (EC) number	5.3.99.4 5.3.99.4
Molecules/complexes with this activity
Homologues of PTGIS [endoplasmic reticulum lumen] Homologues of PTGIS [endoplasmic reticulum lumen] Homologues of PTGIS [endoplasmic reticulum lumen] Homologues of PTGIS [endoplasmic reticulum lumen] PTGIS [endoplasmic reticulum lumen] UKEGBCdORHURP PTGIS [endoplasmic reticulum lumen] UKEEGGBBCCddRHR PTGIS [endoplasmic reticulum lumen] UE PTGIS [endoplasmic reticulum lumen] UKEEGBCdRHR
Reactions catalysed by this activity
Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Homo sapiens] Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Canis familiaris] Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Bos taurus] Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Sus scrofa] Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Mus musculus] Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Rattus norvegicus] Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Xenopus tropicalis] Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2 [Danio rerio]
Is a specialisation of activities
intramolecular oxidoreductase activity GO isomerase activity GO catalytic activity GO molecular_function GO