cholesterol 7-alpha-monooxygenase activity
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Details
name
cholesterol 7-alpha-monooxygenase activity
Accession
GO
Definition
Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.
Enzyme Classification (EC) number
1.14.13.17
1.14.13.17
Molecules/complexes with this activity
Cytochrome P450 7A1 [endoplasmic reticulum membrane]
U
K
E
G
B
C
d
O
R
H
U
R
ENSBTAP00000006957 [endoplasmic reticulum membrane]
E
E
ENSCAFP00000010535 [endoplasmic reticulum membrane]
E
E
ENSTGUP00000011472 [endoplasmic reticulum membrane]
E
E
Homologues of Cytochrome P450 7A1 [endoplasmic reticulum membrane]
Homologues of Cytochrome P450 7A1 [endoplasmic reticulum membrane]
O46491 [endoplasmic reticulum membrane]
U
K
E
P18125 [endoplasmic reticulum membrane]
U
K
E
E
G
B
C
d
R
H
R
Q64505 [endoplasmic reticulum membrane]
U
E
E
G
B
C
d
R
H
R
Q7T2F3 [endoplasmic reticulum membrane]
U
K
E
E
G
G
B
B
C
C
d
d
R
H
R
Reactions catalysed by this activity
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Homo sapiens]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Canis familiaris]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Bos taurus]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Sus scrofa]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Mus musculus]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Rattus norvegicus]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Gallus gallus]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Taeniopygia guttata]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Xenopus tropicalis]
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 [Danio rerio]
Is a specialisation of activities
steroid hydroxylase activity
GO
monooxygenase activity
GO
oxidoreductase activity
GO
catalytic activity
GO
molecular_function
GO
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
GO
monooxygenase activity
GO
oxidoreductase activity
GO
catalytic activity
GO
molecular_function
GO
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO
oxidoreductase activity
GO
catalytic activity
GO
molecular_function
GO
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Date: 2010-09-02 21:55:56
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