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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameD'Eustachio
First namePeter
InitialsP
AffiliationNYU School of Medicine, Department of Biochemistry
Author of summation(s)
A complex consisting of XRCC4 and DNA ligase IV is recruited...
ACER1 (alkaline ceramidase 1), associated with the endoplasm...
ACER3 (alkaline ceramidase 3) catalyzes the hydrolysis of ph...
ALAS2 protein is synthesized at high levels in erythroid pre...
AMP (adenosine monophosphate) is synthesized in two steps fr...
Base excision repair is initiated by DNA glycosylases that h...
Biochemical characterization of purified avian PPAT (chicken...
Biochemical characterization of purified avian PPAT (chicken...
Cellular metabolic processes generate energy through the oxi...
Chicken and human telomeres share many features including th...
Comparison of ALAS1 protein translated in vitro with that re...
Comparison of ALAS2 protein translated in vitro with that re...
Coproporpyrinogen III enters the mitochondrial intermembrane...
CPOX (coproporphyrinogen III oxidase) localized in the mitoc...
Cytosolic ADSL catalyzes the cleavage of adenylosuccinate to...
Cytosolic ADSS catalyzes the reaction of inosine 5'-monophos...
Cytosolic ALAD (delta-aminolevulinate dehydratase) catalyzes...
Cytosolic aldolase catalyzes the reversible reaction of dihy...
Cytosolic aldolase catalyzes the reversible reaction of fruc...
Cytosolic enolase catalyzes the reversible magnesium-depende...
Cytosolic enolase catalyzes the reversible magnesium-depende...
Cytosolic GAPDH catalyzes the reversible reaction of 1,3-bis...
Cytosolic GAPDH catalyzes the reversible reaction of glycera...
Cytosolic glucose 6-phosphate is transported to the endoplas...
Cytosolic GMPS (guanine monophosphate synthetase) catalyzes ...
Cytosolic GOT1 catalyzes the reversible transamination of as...
Cytosolic GOT1 catalyzes the reversible transamination of ox...
Cytosolic HMBS (hydroxymethylbilane synthase) catalyzes the ...
Cytosolic hydroxymethylbilane reacts spontaneously to form u...
Cytosolic IMPDH2 (inosine-5'-monophosphate dehydrogenase 2) ...
Cytosolic lactate dehydrogenase catalyzes the reversible rea...
Cytosolic lactate dehydrogenase catalyzes the reversible rea...
Cytosolic malate dehydrogenase catalyzes the reaction of mal...
Cytosolic NP (purine nucleoside phosphorylase) catalyzes the...
Cytosolic NT5C2 (5'-nucleotidase, cytosolic II) catalyzes th...
Cytosolic PFAS (phosphoribosylformylglycinamidine synthase) ...
Cytosolic PGAM (phosphoglycerate mutase) catalyzes the rever...
Cytosolic PGAM (phosphoglycerate mutase) catalyzes the rever...
Cytosolic PGK (phosphoglycerate kinase) catalyzes the revers...
Cytosolic PGK (phosphoglycerate kinase) catalyzes the revers...
Cytosolic phosphofructokinase 1 (PFK1) catalyzes the irrever...
Cytosolic phosphofructokinase 2 (PFK2) catalyzes the irrever...
Cytosolic PPAT (phosphoribosyl pyrophosphate amidotransferas...
Cytosolic pyruvate kinase (PKM2) catalyzes the irreversible ...
Cytosolic TPI1 (triosephosphate isomerase 1) catalyzes the r...
Cytosolic TPI1 (triosephosphate isomerase 1) catalyzes the r...
Cytosolic UROD (uroporphyrinogen decarboxylase) catalyzes th...
Cytosolic UROD (uroporphyrinogen decarboxylase) catalyzes th...
Cytosolic UROS (uroporphyrinogen III synthase) catalyzes the...
Cytosolic xanthine dehydrogenase (XDH) catalyzes the reactio...
Cytosolic xanthine dehydrogenase (XDH) catalyzes the reactio...
DEGS1 (sphingolipid delta(4)-desaturase 1 / “degenerative sp...
DEGS2 (sphingolipid C4-hydroxylase 2 / degenerative spermato...
Delta-aminolevulinate is transported from the mitochondrial ...
Detection of DNA double-strand breaks involves sensor protei...
Dihydroorotate dehydrogenase catalyzes the oxidation of dihy...
DNA repair is required to maintain the integrity of the cell...
Eight enzymes are involved in heme biosynthesis, four each i...
Expression of ALAS1, the ubiquitous form of delta-aminolevul...
Fanconi anemia (FA) is a rare human hereditary disorder char...
FECH (ferrochelatase) in the mitochondrial matrix catalyzes ...
Following the detection of DSBs, ATM mediates the phosphoryl...
Gamma-H2AX, formed by activated ATM kinase iasan early respo...
Glucose 6-phosphate is hydrolyzed to yield glucose and phosp...
Glucose and orthophosphate generated within the endoplasmic ...
Glucose enters and leaves cells by facilitated diffusion acr...
Glucose enters cells by facilitated diffusion across the pla...
Glucose leaves cells by facilitated diffusion across the pla...
Glucose phosphate isomerase catalyzes the reversible convers...
Glucose phosphate isomerase catalyzes the reversible convers...
GMP (guanosine monophosphate) is synthesized in two steps fr...
KDSR (3-ketodihydrosphingosine reductase) enzyme associated ...
LASS (ceramide synthase / "longevity assurance homolog") enz...
MDH2 (mitochondrial malate dehydrogenase) catalyzes the reve...
Mitochondrial 2-oxoglutarate (alpha-ketoglutarate) dehydroge...
Mitochondrial aconitase catalyzes the reversible isomerizati...
Mitochondrial aconitase catalyzes the reversible isomerizati...
Mitochondrial ALAS (delta-aminolevulinate synthase) catalyze...
Mitochondrial citrate synthase catalyzes the reaction of ace...
Mitochondrial FH (fumarate hydratase) catalyzes the reversib...
Mitochondrial FH (fumarate hydratase) catalyzes the reversib...
Mitochondrial GOT2 catalyzes the reversible transamination o...
Mitochondrial GOT2 catalyzes the reversible transamination o...
Mitochondrial isocitrate dehydrogenase (IDH3-like) catalyzes...
Mitochondrial pyruvate dehydrogenase complex catalyzes the r...
Mitochondrial succinyl-CoA synthetase catalyzes the reversib...
Mitochondrial succinyl-CoA synthetase catalyzes the reversib...
Mitochondrial succinyl-CoA synthetase catalyzes the reversib...
Mitochondrial succinyl-CoA synthetase catalyzes the reversib...
No chicken ortholog of APEX1 (APE1) has been identified expe...
Nucleotides and their derivatives are used for short-term en...
Oxaloacetate is reversibly reduced by NADH + H+ to form mala...
PCK1, the cytosolic form of phosphoenolpyruvate carboxykinas...
PCK2, the mitochondrial matrix form of phosphoenopyruvate ca...
Pol zeta is a heterodimer of REV3L and MAD2L2 (REV7) protein...
PPOX dimer in the mitochondrial intermembrane space catalyze...
Protoporphyrin IX is transported from the mitochondrial inte...
Pyruvate carboxylase catalyzes the reaction of pyruvate, ATP...
Pyruvate sits at an intersection of key pathways of energy m...
Resolution of AP sites can occur through the single-nucleoti...
Several intracellular transport processes and transamination...
Several key pathways of DNA repair in the chicken have been ...
Several subunits of the NER multiprotein repair machinery ar...
SLC25A1, in the inner mitochondrial membrane, mediates the e...
SLC25A10, the mitochondrial dicarboxylate carrier protein in...
SLC25A12 and SLC25A13 each mediate the exchange of cytosolic...
SLC25A21, the mitochondrial 2-oxodicarboxylate carrier, medi...
Sphingolipids are derivatives of sphingosine (trans-1,3-dihy...
SPHK1 (sphingosine kinase 1) catalyzes the reaction of sphin...
SPTLC (serine palmitoyltransferase) enzyme complexes associa...
Telomerase activity has been demonstrated in a variety of ch...
TERC directs the sequential addition of nucleotides to the 3...
TERC directs the sequential addition of nucleotides to the 3...
The adenylosuccinate lyase activity of cytosolic ADSL (adeny...
The aspartate carbamoyltransferase activity of cytosolic CAD...
The carbamoyl-phosphate synthase (glutamine-hydrolyzing) act...
The conversion of inosine monophosphate (IMP) to urate is th...
The dihydroorotase activity of cytosolic CAD hexamer cataly...
The events of purine metabolism are conveniently if somewhat...
The events of pyrimidine metabolism are conveniently if some...
The exchange of cytosolic malate for mitochondrial 2-oxoglut...
The fully replicated chromosome end associates with the shel...
The IMP cyclohydrolase activity of cytosolic ATIC (bifunctio...
The irreversible reaction of cytosolic glucose and ATP to fo...
The mitochondrial uptake of pyruvate is inferred from the pr...
The monocarboxylate transporter:basigin complex, associated ...
The monocarboxylate transporter:basigin complex, associated ...
The nucleoplasmic Pol kappa - Rev1 complex binds the lesione...
The orotate phosphoribosyltransferase activity of dimeric UM...
The orotidine 5'-phosphate decarboxylase activity of dimeric...
The pathways of carbohydrate metabolism are responsible for ...
The phosphatase activity of cytosolic fructose 1,6-bisphosph...
The phosphatase activity of cytosolic phosphofructokinase 2 ...
The phosphoribosylamine-glycine ligase activity of cytosolic...
The phosphoribosylaminoimidazole carboxylase activity of cyt...
The phosphoribosylaminoimidazolecarboxamide formyltransferas...
The phosphoribosylaminoimidazolesuccinocarboxamide synthase ...
The phosphoribosylformylglycinamidine cyclo-ligase activity ...
The phosphoribosylglycinamide formyltransferase activity of ...
The process by which extension of a telomere is terminated h...
The processes by which heme is synthesized, transported, and...
The processing of DNA double strand breaks requires resectin...
The purine ribonucleotide inosine 5'-monophosphate (IMP) is ...
The pyrimidine orotate (orotic acid) is synthesized in a seq...
The reactions of gluconeogenesis convert mitochondrial pyruv...
The reactions of glycolysis convert glucose 6-phosphate to p...
The reactions of the tricarboxylic acid (TCA cycle) mediate ...
The reduction of oxaloacetate to malate is a reaction in com...
The SDH (succinate dehydrogenase) complex, embedded in the i...
The SDH (succinate dehydrogenase) complex, embedded in the i...
The telomerase RNP complex associates specifically with 3’ G...
The telomerase RNP complex is formed in the nucleoplasm from...
Author of entries
'5-phospho-alpha-D-ribose 1-diphosphate [cytosol]' negatively regulates 'Formation of PPAT tetramers'
'Acetyl-CoA [mitochondrial matrix]' is required for 'pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate'
'AMP [cytosol]' negatively regulates 'Formation of PPAT dimers'
'AMP [cytosol]' positively regulates 'Formation of PPAT tetramers'
'D-Fructose 2,6-bisphosphate [cytosol]' negatively regulates 'fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate'
'D-Fructose 2,6-bisphosphate [cytosol]' positively regulates 'fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP'
'etiocholanolone [nucleoplasm]' positively regulates 'Synthesis of ALAS1 nascent polypeptide'
'GMP [cytosol]' negatively regulates 'Formation of PPAT dimers'
'GMP [cytosol]' positively regulates 'Formation of PPAT tetramers'
'hemin [cytosol]' negatively regulates 'Synthesis of ALAS1 nascent polypeptide'
'IMP [cytosol]' negatively regulates 'Formation of PPAT dimers'
'Magnesium [cytosol]' is required for '2-phosphoglycerate <=> phosphoenolpyruvate + H2O'
'Magnesium [cytosol]' is required for 'phosphoenolpyruvate + H2O <=> 2-phosphoglycerate'
'Mg++ [mitochondrial matrix]' is required for 'pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate'
'monoubiquitinated PCNA [nucleoplasm]' positively regulates 'Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site.'
'NHP2 [nucleoplasm]' positively regulates 'Assembly of telomerase RNP'
'PIF1 [nucleoplasm]' positively regulates 'Dissociation of telomerase RNP from the extended chromosomal end'
'PRPP [cytosol]' positively regulates 'Formation of PPAT dimers'
'RUVBL1 [nucleoplasm]' positively regulates 'Assembly of telomerase RNP'
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity of ADSL [cytosol]
(S)-dihydroorotate + ubiquinone => orotate + ubiquinol [Gallus gallus]
/figures/Gg_gluconeogenesis.jpg
/figures/Gg_mitotic_telomeres.jpg
1,3-bisphosphoglycerate + ADP <=> 3-phosphoglycerate + ATP [Gallus gallus]
1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate [Gallus gallus]
10-formyl-THF [cytosol] CCPZ
2 delta-aminolevulinate => porphobilinogen + 2 H2O [Gallus gallus]
2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O [Gallus gallus]
2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ [Gallus gallus]
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] [Gallus gallus]
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] [Gallus gallus]
2-oxoglutarate dehydrogenase complex [mitochondrial matrix]
2-phosphoglycerate <=> 3-phosphoglycerate [Gallus gallus]
2-phosphoglycerate <=> phosphoenolpyruvate + H2O [Gallus gallus]
3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ [Gallus gallus]
3-dehydrosphinganine reductase activity of KDSR [endoplasmic reticulum membrane]
3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP [Gallus gallus]
3-phosphoglycerate <=> 2-phosphoglycerate [Gallus gallus]
4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 [Gallus gallus]
5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) [Gallus gallus]
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate [Gallus gallus]
5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate [Gallus gallus]
5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate [Gallus gallus]
5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O [Gallus gallus]
5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate [Gallus gallus]
5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate [Gallus gallus]
5-aminolevulinate synthase activity of ALAS dimer [mitochondrial matrix]
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate [Gallus gallus]
5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate [Gallus gallus]
5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate [Gallus gallus]
6-phosphofructo-2-kinase activity of PFKFB4 dimer [cytosol]
6-phosphofructokinase activity of PFK1 [cytosol]
ACD [nucleoplasm] E
ACER1 [endoplasmic reticulum membrane] E
ACER3 [endoplasmic reticulum membrane] E
acetyl-CoA + H2O + oxaloacetate => citrate + CoA [Gallus gallus]
acidic amino acid transmembrane transporter activity of mitochondrial aspartate glutamate carrier [mitochondrial inner membrane]
ACO2 [mitochondrial matrix] UENBCdRHPR
aconitate hydratase activity of ACO2 [mitochondrial matrix]
adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate [Gallus gallus]
adenylosuccinate synthase activity of ADSS [cytosol]
ADSL [cytosol] UENBCdRHPR
ADSS [cytosol] UENBCdRHPR
ALAD [cytosol] E
ALAD octamer [cytosol]
ALAS dimer [mitochondrial matrix]
ALAS1 [mitochondrial matrix] UP
ALAS1 dimer [mitochondrial matrix]
ALAS1 nascent polypeptide [cytosol] UP
ALAS2 [mitochondrial matrix] UP
ALAS2 dimer [mitochondrial matrix]
ALAS2 nascent polypeptide [cytosol] UP
ALDOB [cytosol] UENBCdP
ALDOC [cytosol] UP
aldolase [cytosol]
ALKBH2 and 3 [nucleoplasm]
alpha-ketoglutarate transmembrane transporter activity of SLC25A21 [mitochondrial inner membrane]
amidophosphoribosyltransferase activity of PPAT dimer [cytosol]
Amino acid metabolism [Gallus gallus]
APEX1 [nucleoplasm]
ARG2 [mitochondrial matrix] E
ASL-like [cytosol]
ASL1-like [cytosol] UENBCdRHPR
ASL2 [cytosol] UENBCdP
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate [Gallus gallus]
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate [Gallus gallus]
aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] [Gallus gallus]
aspartate carbamoyltransferase activity of CAD hexamer [cytosol]
ASS1 [cytosol] E
Assembly of telomerase and telomere extension [Gallus gallus]
Assembly of telomerase RNP [Gallus gallus]
ATIC [cytosol] UENBCdRHPPPPPPPPRDDDDDDD
ATIC dimer [cytosol]
BPGM [cytosol] UENBCdRHPR
BSG isoform 1 [plasma membrane] UP
BSG isoform 2 [plasma membrane] UP
BSG isoforms [plasma membrane]
CAD [cytosol] E
CAD hexamer [cytosol]
carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate [Gallus gallus]
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of CAD hexamer [cytosol]
Carbohydrate metabolism [Gallus gallus]
ceramidase activity of ACER1 [endoplasmic reticulum membrane]
ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] [Gallus gallus]
citrate (Si)-synthase activity of citrate synthase dimer [mitochondrial matrix]
citrate <=> isocitrate [Gallus gallus]
citrate synthase dimer [mitochondrial matrix]
coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 [Gallus gallus]
coproporphyrinogen oxidase activity of CPOX dimer [mitochondrial intermembrane space]
CPOX [mitochondrial intermembrane space] E
CPOX dimer [mitochondrial intermembrane space]
CS monomer [mitochondrial matrix] UP
De novo synthesis of AMP [Gallus gallus]
De novo synthesis of GMP [Gallus gallus]
De novo synthesis of IMP [Gallus gallus]
De novo synthesis of UMP [Gallus gallus]
DEGS1 [endoplasmic reticulum membrane] UENBCdRHPR
DEGS2 [endoplasmic reticulum membrane] E
DHODH [mitochondrial inner membrane] UENBCdRHPR
DHODH holoenzyme [mitochondrial inner membrane]
DHTKD1 [mitochondrial matrix] E
dicarboxylic acid transmembrane transporter activity of SLC25A10 [mitochondrial inner membrane]
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O [Gallus gallus]
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O [Gallus gallus]
dihydroorotase activity of CAD hexamer [cytosol]
dihydroorotate dehydrogenase activity of DHODH holoenzyme [mitochondrial inner membrane]
dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate [Gallus gallus]
dihydroxyacetone phosphate <=> glyceraldehyde 3-phosphate [Gallus gallus]
Dissociation of telomerase RNP from the extended chromosomal end [Gallus gallus]
DKC1 [nucleoplasm] UENBCdRHPR
DLAT [mitochondrial matrix] E
DLD [mitochondrial matrix] E
DLST [mitochondrial matrix] E
DNA containing unligated replacement-synthesized patch [nucleoplasm]
DNA ligase activity of DNA-PK:XRCC4:DNA ligase IV:DNA complex associated with ligatable DNA ends [nucleoplasm]
DNA N-glycosylase activity of TDG [nucleoplasm]
DNA replication and repair [Gallus gallus]
DNA-N1-methyladenine dioxygenase activity of ALKBH2 and 3 [nucleoplasm]
Efflux of glucose and orthophosphate from the endoplasmic reticulum [Gallus gallus]
Elongation and translocation of the extended telomeric chromosome end [Gallus gallus]
Elongation and translocation of the telomeric chromosome end [Gallus gallus]
ENO1 [cytosol] UENBCdRHPPRD
ENO1 homodimer [cytosol]
ENO1:ENO2 heterodimer [cytosol]
ENO2 [cytosol] UENBCdRHPR
ENO2 homodimer [cytosol]
ENO3 [cytosol] UP
ENO3 homodimer [cytosol]
enolase dimer [cytosol]
etiocholanolone [nucleoplasm] CZ
Extended And Processed Telomere End [nucleoplasm]
FBP [cytosol]
FBP1 [cytosol] UENBCdP
FBP2 [cytosol] UENBCdP
FECH [mitochondrial matrix] UENBCdRHPR
FECH dimer [mitochondrial matrix]
ferrochelatase activity of FECH dimer [mitochondrial matrix]
FH [mitochondrial matrix] E
Formation of PPAT dimers [Gallus gallus]
Formation of PPAT tetramers [Gallus gallus]
fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate [Gallus gallus]
fructose 1,6-bisphosphate 1-phosphatase activity of FBP [cytosol]
fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + glyceraldehyde 3-phosphate [Gallus gallus]
fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate [Gallus gallus]
fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP [Gallus gallus]
fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP [Gallus gallus]
fructose 6-phosphate <=> glucose 6-phosphate [Gallus gallus]
fructose-2,6-bisphosphate 2-phosphatase activity of PFKFB4 dimer [cytosol]
fructose-bisphosphate aldolase activity of aldolase [cytosol]
fumarate + FADH2 <=> succinate + FAD [Gallus gallus]
fumarate + H2O <=> malate [Gallus gallus]
fumarate hydratase activity of FH [mitochondrial matrix]
G6PC [endoplasmic reticulum membrane] E
G6PC2 [endoplasmic reticulum membrane] E
GAPDH [cytosol] UENNBBCCddPR
GAPDH tetramer [cytosol]
GART [cytosol] UENBCdRHPR
GCK [cytosol] UP
glucokinase activity of hexokinases [cytosol]
Gluconeogenesis [Gallus gallus]
glucose + ATP => glucose 6-phosphate + ADP [Gallus gallus]
glucose 6-phosphatase [endoplasmic reticulum membrane]
glucose 6-phosphate + H2O => glucose + phosphate [Gallus gallus]
glucose 6-phosphate <=> fructose 6-phosphate [Gallus gallus]
glucose 6-phosphate [cytosol] => glucose 6-phosphate [endoplasmic reticulum lumen] [Gallus gallus]
glucose [cytosol] <=> glucose [extracellular] [Gallus gallus]
glucose [extracellular] <=> glucose [cytosol] [Gallus gallus]
glucose transmembrane transporter activity of GLUT proteins [plasma membrane]
Glucose transport [Gallus gallus]
glucose-6-phosphatase activity of glucose 6-phosphatase [endoplasmic reticulum membrane]
glucose-6-phosphate isomerase activity of GPI [cytosol]
glucose-6-phosphate transmembrane transporter activity of SLC37A4 [endoplasmic reticulum membrane]
GLUT proteins [plasma membrane]
glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+ [Gallus gallus]
glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate [Gallus gallus]
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramer [cytosol]
Glycolysis [Gallus gallus]
GMP synthase (glutamine-hydrolyzing) activity of GMPS [cytosol]
GMPS [cytosol] E
GOT1 [cytosol] UENBCdRHPPPRDD
GOT1 dimer [cytosol]
GOT2 [mitochondrial matrix] UENBCdRHPPPPPPPPPPPPPPPPRDDDDDDDDDDDDDDD
GOT2 dimer [mitochondrial matrix]
GPI [cytosol] UENBCdRHPR
Heme metabolism [Gallus gallus]
Heme synthesis [Gallus gallus]
hemin [cytosol] CC
hexokinases [cytosol]
HK1 [cytosol] UENBCdRHPR
HK2 [cytosol] E
HK2 [cytosol] UENBCdRHPR
HMBS [cytosol] E
HMBS holoenzyme [cytosol]
hydroxymethylbilane => uroporphyrinogen I + H2O [Gallus gallus]
hydroxymethylbilane => uroporphyrinogen III + H2O [Gallus gallus]
hydroxymethylbilane synthase activity of HMBS holoenzyme [cytosol]
hypothetical 2-oxoglutarate/malate carrier protein [mitochondrial inner membrane]
hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ [Gallus gallus]
hypoxanthine dehydrogenase activity of XDH [cytosol]
IDH3-like [mitochondrial matrix] E
IMP 5'-nucleotidase activity of NT5C2 [cytosol]
IMP cyclohydrolase activity of ATIC dimer [cytosol]
IMP dehydrogenase activity of IMPDH2 [cytosol]
IMPDH2 [cytosol] UEP
inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate [Gallus gallus]
inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate [Gallus gallus]
inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate [Gallus gallus]
inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ [Gallus gallus]
isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ [Gallus gallus]
isocitrate <=> citrate [Gallus gallus]
isocitrate dehydrogenase (NAD+) activity of IDH3-like [mitochondrial matrix]
K63-ubiquitin (RPS27A) [cytosol] UENBCdRHPR
K63-ubiquitin (RPS27A) [endosome membrane] UENBCdRHPR
K63-ubiquitin (UBA52) [cytosol] UP
K63-ubiquitin (UBA52) [endosome membrane] UP
K63-ubiquitin (UBB 1) [cytosol] UP
K63-ubiquitin (UBB 1) [endosome membrane] UP
K63-ubiquitin (UBB 2) [cytosol] UP
K63-ubiquitin (UBB 2) [endosome membrane] UP
K63-ubiquitin (UBB 3) [cytosol] UP
K63-ubiquitin (UBB 3) [endosome membrane] UP
K63-ubiquitin (UBB 4) [cytosol] UP
K63-ubiquitin (UBB 4) [endosome membrane] UP
KDSR [endoplasmic reticulum membrane] UENBCdRHPR
L-Arg [mitochondrial matrix] CCPZ
L-aspartate:2-oxoglutarate aminotransferase activity of GOT1 dimer [cytosol]
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate [Gallus gallus]
L-lactate dehydrogenase activity of LDH tetramer isoforms [cytosol]
L-malate dehydrogenase activity of MDH1 [cytosol]
L-malate dehydrogenase activity of MDH2 [mitochondrial matrix]
LACT [extracellular region] CCPZ
lactate + H+ [cytosol] <=> lactate + H+ [extracellular] [Gallus gallus]
lactate + H+ [extracellular] <=> lactate + H+ [cytosol] [Gallus gallus]
lactate + NAD+ <=> pyruvate + NADH + H+ [Gallus gallus]
lactate transmembrane transporter activity of monocarboxylate transporter:BSG tetramer [plasma membrane]
LASS proteins [endoplasmic reticulum membrane]
LASS3 [endoplasmic reticulum membrane] E
LASS4 [endoplasmic reticulum membrane] E
LASS5 [endoplasmic reticulum membrane] E
LASS6 [endoplasmic reticulum membrane] E
LDH A2B2 tetramer [cytosol]
LDH A3B tetramer [cytosol]
LDH A4 tetramer [cytosol]
LDH AB3 tetramer [cytosol]
LDH B4 tetramer [cytosol]
LDH tetramer isoforms [cytosol]
LDHA [cytosol] UENBCdRHPR
LDHB [cytosol] UENBCdRHPR
Ligated patch-repaired DNA [nucleoplasm]
Lipid metabolism [Gallus gallus]
malate + NAD+ <=> oxaloacetate + NADH + H+ [Gallus gallus]
malate + NAD+ <=> oxaloacetate + NADH + H+ [Gallus gallus]
malate <=> fumarate + H2O [Gallus gallus]
malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] [Gallus gallus]
MDH1 [cytosol] UENBCdRHPR
MDH2 [mitochondrial matrix] E
Metabolism [Gallus gallus]
mitochondrial aspartate glutamate carrier [mitochondrial inner membrane]
mitochondrial pyruvate carrier [mitochondrial inner membrane]
Mitochondrial uptake and processing of ALAS1 [Gallus gallus]
Mitochondrial uptake and processing of ALAS2 [Gallus gallus]
monocarboxylate transporter homodimers [plasma membrane]
monocarboxylate transporter:BSG tetramer [plasma membrane]
N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O [Gallus gallus]
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity of ADSL [cytosol]
NHP2 [nucleoplasm] E
NP [cytosol] E
NT5C2 [cytosol] UENBCdRHPR
Nucleotide metabolism [Gallus gallus]
OGDH-like [mitochondrial matrix]
OGDHL [mitochondrial matrix] E
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate [Gallus gallus]
orotate phosphoribosyltransferase activity of UMPS dimer [cytosol]
orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 [Gallus gallus]
orotidine-5'-phosphate decarboxylase activity of UMPS dimer [cytosol]
OTC [mitochondrial matrix] UENBCdRHPR
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) [Gallus gallus]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) [Gallus gallus]
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] [Gallus gallus]
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] [Gallus gallus]
oxaloacetate + NADH + H+ <=> malate + NAD+ [Gallus gallus]
oxoglutarate dehydrogenase (NAD+) activity of 2-oxoglutarate dehydrogenase complex [mitochondrial matrix]
oxoglutarate:malate antiporter activity of hypothetical 2-oxoglutarate/malate carrier protein [mitochondrial inner membrane]
oxygen-dependent protoporphyrinogen oxidase activity of PPOX dimer [mitochondrial intermembrane space]
Packaging of telomere ends [Gallus gallus]
PAICS [cytosol] UENBCdRHPRZ
PAICS octamer [cytosol]
palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 [Gallus gallus]
PCCA [mitochondrial matrix] E
PCK1 [cytosol] UENBCdRHPR
PCK2 [mitochondrial matrix] UP
PCX [mitochondrial matrix] UP
PDHA1 [mitochondrial matrix] E
PFAS [cytosol]
PFK1 [cytosol]
PFKFB4 [cytosol] UP
PFKFB4 dimer [cytosol]
PFKL [cytosol] UENBCdP
PFKM [cytosol] UP
PFKP [cytosol] E
PGAM [cytosol]
PGAM1 [cytosol] UENBCdRHPR
PGAM5 [cytosol] E
PGK1 [cytosol] UENBCdRHPR
phosphoenolpyruvate + ADP => pyruvate + ATP [Gallus gallus]
phosphoenolpyruvate + H2O <=> 2-phosphoglycerate [Gallus gallus]
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] [Gallus gallus]
phosphoenolpyruvate carboxykinase (GTP) activity of PCK1 [cytosol]
phosphoenolpyruvate carboxykinase (GTP) activity of PCK2 [mitochondrial matrix]
phosphoglycerate kinase activity of PGK1 [cytosol]
phosphoglycerate mutase activity of PGAM [cytosol]
phosphopyruvate hydratase activity of enolase dimer [cytosol]
phosphoribosylamine-glycine ligase activity of GART [cytosol]
phosphoribosylaminoimidazole carboxylase activity of PAICS octamer [cytosol]
phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity of PAICS octamer [cytosol]
phosphoribosylformylglycinamidine cyclo-ligase activity of GART [cytosol]
phosphoribosylformylglycinamidine synthase activity of PFAS [cytosol]
phosphoribosylglycinamide formyltransferase activity of GART [cytosol]
phytoceramidase activity of ACER3 [endoplasmic reticulum membrane]
phytoceramide + H2O => stearate + phytosphingosine [Gallus gallus]
PIF1 [nucleoplasm] E
PKM2 [cytosol] UENBCdRHPR
POLD3 [nucleoplasm] UENBCdRHPR
porphobilinogen synthase activity of ALAD octamer [cytosol]
POT1 [nucleoplasm] UENNNBBBCCCdddPR
PPAT [cytosol] UENBCdP
PPAT dimer [cytosol]
PPAT tetramer [cytosol]
PPOX [mitochondrial intermembrane space]
PPOX dimer [mitochondrial intermembrane space]
protein kinase activity of Activated-ATM kinase [nucleoplasm]
protoporphyrin IX + Fe++ => heme + 2 H+ [Gallus gallus]
Purine metabolism [Gallus gallus]
purine-nucleoside phosphorylase activity of NP [cytosol]
PYC [mitochondrial matrix]
PYC-like1:biotin [mitochondrial matrix]
PYC-like1:biotin tetramer [mitochondrial matrix]
PYC:biotin [mitochondrial matrix]
PYC:biotin tetramer [mitochondrial matrix]
Pyrimidine metabolism [Gallus gallus]
pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate [Gallus gallus]
pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ [Gallus gallus]
pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] [Gallus gallus]
pyruvate + NADH + H+ <=> lactate + NAD+ [Gallus gallus]
pyruvate carboxylase activity of PYC [mitochondrial matrix]
pyruvate dehydrogenase (NAD+) activity of pyruvate dehydrogenase complex [mitochondrial matrix]
pyruvate dehydrogenase complex [mitochondrial matrix]
pyruvate kinase activity of PKM2 [cytosol]
Pyruvate metabolism [Gallus gallus]
pyruvate transmembrane transporter activity of mitochondrial pyruvate carrier [mitochondrial inner membrane]
Recruitment of telomerase RNP to a telomeric chromosome end [Gallus gallus]
RUVBL1 [nucleoplasm] UENBCdRHPR
SDH complex [mitochondrial inner membrane]
SDHA [mitochondrial inner membrane] UENBCdPPD
SDHB [mitochondrial inner membrane] UENBCdPPPPPDDDD
SDHC [mitochondrial inner membrane]
SDHD [mitochondrial inner membrane] E
serine C-palmitoyltransferase activity of SPTLC 2 and 3 complexes [endoplasmic reticulum membrane]
shelterin [nucleoplasm]
shelterin:telomere with t-loop [nucleoplasm]
SLC16A1 [plasma membrane] E
SLC16A1 homodimer [plasma membrane]
SLC16A3 [plasma membrane] UENBCdRHPR
SLC16A3 homodimer [plasma membrane]
SLC16A7 [plasma membrane] E
SLC16A7 homodimer [plasma membrane]
SLC16A8 [plasma membrane] E
SLC16A8 homodimer [plasma membrane]
SLC25A1 [mitochondrial inner membrane] E
SLC25A10 [mitochondrial inner membrane]
SLC25A12 [mitochondrial inner membrane] E
SLC25A13 [mitochondrial inner membrane] E
SLC25A15 [mitochondrial inner membrane] UENBCdRHPR
SLC25A15, SLC25A2 [mitochondrial inner membrane]
SLC25A2 [mitochondrial inner membrane] E
SLC25A21 [mitochondrial inner membrane] E
SLC2A1 [plasma membrane] UENBCdRHPR
SLC2A2 [plasma membrane] UENBCdRHPR
SLC2A3 [plasma membrane] UENBCdRHPR
SLC37A4 [endoplasmic reticulum membrane] E
sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP [Gallus gallus]
sphinganine + stearyl-CoA => dihydroceramide + CoASH [Gallus gallus]
sphinganine kinase activity of SPHK1 [cytosol]
sphingolipid delta-4 desaturase activity of DEGS1 [endoplasmic reticulum membrane]
Sphingolipid metabolism [Gallus gallus]
sphingosine hydroxylase activity of DEGS2 [endoplasmic reticulum membrane]
sphingosine N-acyltransferase activity of LASS proteins [endoplasmic reticulum membrane]
SPHK1 [cytosol] E
SPTLC 2 and 3 complexes [endoplasmic reticulum membrane]
SPTLC1 [endoplasmic reticulum membrane] E
SPTLC1:SPTLC2 [endoplasmic reticulum membrane]
SPTLC1:SPTLC3 [endoplasmic reticulum membrane]
SPTLC2 [endoplasmic reticulum membrane] UENBCdRHPR
SPTLC3 [endoplasmic reticulum membrane] E
succinate + CoASH + ATP <=> succinylCoA + ADP + Pi [Gallus gallus]
succinate + CoASH + GTP <=> succinylCoA + GDP + Pi [Gallus gallus]
succinate + FAD <=> fumarate + FADH2 [Gallus gallus]
succinate dehydrogenase (ubiquinone) activity of SDH complex [mitochondrial inner membrane]
succinate-CoA ligase (ADP-forming) activity of succinyl-CoA synthetase dimer, ADP-forming [mitochondrial matrix]
succinate-CoA ligase (GDP-forming) activity of succinyl-CoA synthetase dimer, GDP-forming [mitochondrial matrix]
succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2 [Gallus gallus]
succinyl-CoA synthetase dimer, ADP-forming [mitochondrial matrix]
succinyl-CoA synthetase dimer, GDP-forming [mitochondrial matrix]
succinylCoA + ADP + Pi <=> succinate + CoASH + ATP [Gallus gallus]
succinylCoA + GDP + Pi <=> succinate + CoASH + GTP [Gallus gallus]
SUCLA1-like [mitochondrial matrix]
SUCLA2 [mitochondrial matrix]
SUCLA2 [mitochondrial matrix] E
SUCLG1 [mitochondrial matrix]
SUCLG2 [mitochondrial matrix] E
Synthesis of ALAS1 nascent polypeptide [Gallus gallus]
Synthesis of ALAS2 nascent polypeptide [Gallus gallus]
telomerase activity of telomerase RNP:G-strand complex [nucleoplasm]
telomerase activity of telomerase RNP:G-strand complex with one added single-stranded repeat [nucleoplasm]
telomerase RNP [nucleoplasm]
telomerase RNP:G-strand complex [nucleoplasm]
telomerase RNP:G-strand complex with one added single-stranded repeat [nucleoplasm]
telomerase RNP:G-strand complex with two added single-stranded repeats [nucleoplasm]
Telomere maintenance [Gallus gallus]
TERC RNA [nucleoplasm] E
TERF1 [nucleoplasm] UEP
TERF2 [nucleoplasm] UENBCdP
TERF2IP [nucleoplasm] UENBCdRHPR
TERT [nucleoplasm] UENBCdRHPR
The tricarboxylic acid cycle [Gallus gallus]
TPI1 [cytosol] UENBCdRHPPPPPPPPPPPPPPPPPRDDDDDDDDDDDDDDDD
TPI1 dimer [cytosol]
Translocation of coproporphyrinogen III from the cytosol to the mitochondrial intermembrane space [Gallus gallus]
Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol [Gallus gallus]
Transport of protoporphyrin IX from the mitochondrial intermembrane space into the mitochondrial matrix [Gallus gallus]
tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane]
triose-phosphate isomerase activity of TPI1 dimer [cytosol]
ubiquitin (RPS27A) [cytosol] UENBCdRHPR
ubiquitin (RPS27A) [nucleoplasm] UENBCdRHPR
ubiquitin (UBA52) [cytosol] UP
ubiquitin (UBA52) [nucleoplasm] UP
ubiquitin (UBB 1) [cytosol] UP
ubiquitin (UBB 1) [nucleoplasm] UP
ubiquitin (UBB 2) [cytosol] UP
ubiquitin (UBB 2) [nucleoplasm] UP
ubiquitin (UBB 3) [cytosol] UP
ubiquitin (UBB 3) [nucleoplasm] UP
ubiquitin (UBB 4) [cytosol] UP
ubiquitin (UBB 4) [nucleoplasm] UP
ubiquitin-specific protease activity of USP1 [nucleoplasm]
ubiquitinylated lysine at 139
ubiquitinylated lysine at 215
ubiquitinylated lysine at 291
ubiquitinylated lysine at 4
ubiquitinylated lysine at 63
ubiquitinylated lysine at 63
UMPS [cytosol] UENBCdRHPR
UMPS dimer [cytosol]
uracil DNA N-glycosylase activity of UNG [nucleoplasm]
Urate synthesis [Gallus gallus]
Urea [mitochondrial matrix] CCPZ
UROD [cytosol] E
UROD dimer [cytosol]
uroporphyrinogen decarboxylase activity of UROD dimer [cytosol]
uroporphyrinogen I => coproporphyrinogen I + 4 CO2 [Gallus gallus]
uroporphyrinogen III => coproporphyrinogen III + 4 CO2 [Gallus gallus]
uroporphyrinogen-III synthase activity of UROS [cytosol]
UROS [cytosol] E
USP1 [nucleoplasm] UENBCdRHPR
xanthine + H2O + NAD+ => urate + NADH + H+ [Gallus gallus]
xanthine dehydrogenase activity of XDH [cytosol]
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate [Gallus gallus]
XDH [cytosol] UENBCdRHPR