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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P25054
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Adenomatous polyposis coli protein shortName:Protein APC alternativeName: Deleted in polyposis 2.5
Links to corresponding entries in other databasesBioGPS Gene:324
CTD Gene:324
DOCK Blaster:1DEB
DOCK Blaster:1EMU
DOCK Blaster:1JPP
DOCK Blaster:1M5I
DOCK Blaster:1T08
DOCK Blaster:1TH1
DOCK Blaster:1V18
ENSEMBL:ENSG00000134982
GeneCards:P25054
HapMap:NM_000038
KEGG Gene:324
NCBI Gene:324
OMIM:135290
OMIM:155255
OMIM:175100
OMIM:276300
Orphanet:16443
PRO:P25054
Protein Data Bank:1DEB
Protein Data Bank:1EMU
Protein Data Bank:1JPP
Protein Data Bank:1M5I
Protein Data Bank:1T08
Protein Data Bank:1TH1
Protein Data Bank:1V18
RefSeq:NM_000038
RefSeq:NP_000029
UCSC human:P25054
UniProt:P25054
dbSNP Gene:324
Other identifiers related to this sequenceAPC_HUMAN, D3DT03, Q15162, Q15163, Q93042, HPA013349, NM_000038, ENSP00000257430, uc003kpy.4, 8107330, 2824274, A_14_P135872, APC-001, PF05956, 3NMX, AAF34355, CH471086, AC008575, MIM:611731, AH009132, PH_hs_0031313, 1JPP, 203525_s_at, EU681189, Hs.75081.0.S2_3p_a_at, 2824266, IPR009224, A5HB96, IPR009232, 2824268, 2824225, EAW49002, Hs.621884, AAA03586, Q9UM98, ABQ09218, CAB025994, APC, 36182_at, g4557318_3p_a_at, A_14_P106747, A5HB97, PF05972, 2824277, 203526_s_at, ABL98125, EntrezGene:324, 2824253, PF11414, 2824267, 2824273, MIM:276300, M73548_at, 1912_s_at, S78214, IPR009234, 2RQU, 2824258, NP_000029, 3AU3, A_14_P116796, 2824239, 216933_x_at, Q4LE70, M74088, 1DEB, 0004920746, B2ZRE1, 2824257, LRG_130, 1EMU, AAG25599, D6RFL6, 2824248, 2824232, EF432779, 1V18, PF05923, A5HB95, 216933_3p_x_at, 2824230, ACD11098, CCDS4107, E9PFT7, 2824218, 1T08, MIM:135290, 324, 3NMW, AB210001, S67788, 2824275, PF05924, MIM:114550, ENSG00000134982, 4G69, IPR009240, 1M5I, 2824244, 11731561_a_at, ABQ09217, M74088_s_at, Hs.727274, 2824272, AAD13998, 3RL8, IPR026831, EAW49007, 1651563, UPI000013CF60, Hs.158932, 203527_s_at, 11757692_s_at, IPR016024, IPR009223, HGNC:583, Q9P119, ILMN_1662668, MIM:175100, g182396_3p_a_at, IPR000225, 2824279, 2824256, Q9HAW6, 3NMZ, AAB21145, Hs.75081.1.S1_3p_a_at, 2824276, MIM:613659, AC136500, A1YIQ7, A_33_P3408983, 1TH1, GE58061, A_23_P70213, AH009913, SM00185, 2824245, 2824233, AAA60354, BAE06083, 16988021, MIM:155255, AAA60353, EF026097, PF00514, 3QHE, 3RL7, A5HB94, ABQ09219, OTTHUMP00000159019, 11731562_s_at, 3T7U, M73548, Hs.645638, Hs.739006, PF05937, ABQ09220, OTTHUMP00000222841, NM_001127510, 2824220, NP_001120982, ENSP00000427089, APC-004, uc003kpz.4
Molecules with this sequenceAPC(778-2843) [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC(1-777) [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
p-ub-APC [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC [nucleoplasm] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC G1309Dfs*4 [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC E1554* [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC I1417 fs*2 [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC S811* [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC Q1338* [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC F1197* [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
K63 ub-APC [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
APC R1450* [cytosol] UKENBCdOOOOORHPGPPPPPPPURDDDDDDD
Component ofp-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
p-S33,S37,T41,S45-beta-catenin:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
p-S33,S37,T41,S45-beta-catenin:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
APC:CTBP:CTNNB1:BTRC [nucleoplasm]
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol]
...
List all 22 items
Represented by generalisation(s)APC truncation mutants [cytosol]
APC polyubiquitination mutants [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Apoptosis

Disease

Modifications in molecules with this sequencephosphorylated residue at unknown position
Replacement of residues 1309 to 1311 by DWN
ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
Replacement of residues 1417 to 1417 by L
L-arginine 1450 replaced with unknown
L-glutamic acid 1554 replaced with unknown
L-glutamine 1338 replaced with unknown
L-phenylalanine 1197 replaced with unknown
L-serine 811 replaced with unknown
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