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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameShamovsky
First nameVeronica
InitialsV
AffiliationNYU School of Medicine, Department of Biochemistry
Author of summation(s)
Activated mammalian MEK1/2 is a serine/threonine kinase, wh...
Activation of lectin pathway begins when mannan-binding lect...
Although RLR-mediated signaling to NFkB and MAPK shares simi...
Anaphylatoxic peptides C3a and C5a function as mediators of ...
Antiviral responses must be tightly regulated in order to pr...
Bioinformatics analysis of the chicken genome revealed a pat...
Both mannose-binding lectin (MBL) and ficolins are lectins, ...
C1 complex undergoes conformational changes which result in ...
C2 binds to surface-bound C4b to form the C4b:C2 complex, wh...
C3b molecules are continuously deposited onto target surface...
C3b, a product of the enzymatic action of C3 convertases on ...
C4 is cleaved by activated protease C1s in the classical pat...
C4b and C3b are opsonins, which are able to bind covalently ...
C4b binding to the target surface is regulated by a hydrolys...
C5 convertases are serine proteases that cleave complement C...
Chicken CD14 was reported to be involved in chicken TLR4 act...
chicken complement factor D is annotated as a hypothetical p...
Chicken ERK2 shares 99% of amino acid sequence identity with...
Chicken TLR21 was demonstrated to use a MyD88-dependent pat...
Chicken TLR21 was shown to respond to both bacterial chromos...
Chickens express TLR21 which is absent in human; chTLR21 has...
Cleavage of C4 exposes an active thioester bond on the large...
Complement activity is non-specific and requires the assembl...
Complement C7 binds C5b:C6 to form the C5b:C6:C7 hydrophobic...
Complement C9 is the final component incorporated into the m...
Complement factor I (CFI) is a serine protease that inhibits...
Complement factor I (CFI) is a serine protease that inhibits...
Complement protein C1q binds either to antibody-antigen comp...
Conformational changes in the C1 complex result in activatio...
CREG has the ability to protect host cells from chicken comp...
CREM, a complement regulatory protein in chicken, consists o...
Expression of chicken TLR21 in HEK293 was shown to upregulat...
Factor H accelerates the decay of existing C3/5 convertases ...
Gene encoding complement regulatory GPI-anchored protein (CR...
Human factor B is cleaved by factor D yielding a small fragm...
Human vitronectin interacts with C5b:C6:C7 complex preventin...
In human, RIG-I-like receptor (RLR) family is crucial for tr...
In human, small amounts of hydrolyzed C3 (C3(H20) or C3i) ar...
In human, small amounts of hydrolyzed C3 (C3(H20) or C3i) ar...
In mammals, C3b binds covalently to a specific site on the C...
In mammals, C3b binds covalently to a specific site on the C...
In mammals, C6 interacts with C5b through a metastable bindi...
In mammals, C8 binds to the membrane-bound C5b:C6:C7 complex...
In mammals, complement C3a receptor (C3aR) is a member of th...
In mammals, complement C5a receptor (C5aR) is a member of th...
In mammals, extracellular factor H binds negatively-charged ...
In mammals, fluid-phase C3i interacts with factor B which, i...
In mammals, IKKs (IkB kinase complex) were shown to interact...
In mammals, inactivated C3b (iC3b) undergoes proteolytic cle...
In mammals, IRF3 and IRF7 (IRF3/IRF7) are the two major memb...
In mammals, reactions following C5b formation are common to ...
In mammals, the alternative pathway is activated either by s...
In mammals, the classical pathway is initiated by binding of...
In mammals, the interaction of flagellin with TLR5 induces a...
In mammals, the response to viral infection is mediated thro...
In mammals, three pathways of complement activation - altern...
In mammals, three pathways of complement activation - altern...
In mammals, TLR7 and TLR8 belong to TLR9 subfamily and sense...
In mammals, virus-triggered RIG-1 or MDA5 receptor complex h...
In the classical and lectin-mediated pathways C3 convertase ...
Induction of inflammatory cytokines in response to poly(I:C)...
Innate immunity also known as nonspecific immunity provides ...
It's believed that TAK1 dissociates from the membrane in to ...
Like its human counterpart chicken TLR5 recognizes and respo...
Lipopolysaccharide and flagellin were shown to stimulate ERK...
LPS stimulation results in the formation of mammalian TLR4:M...
Mammalian C2 binds to surface-bound C4b to form the C4b:C2 c...
Mammalian CD59, the major inhibitor of the complement membra...
Mammalian factor H (CFH or FH) can bind both fluid phase and...
Mammalian factor H (CFH or FH) can bind both fluid phase and...
Mammalian IPS-1 was shown to interact with death domain (DD)...
Mammalian MEKK1 was reported to be involved to IPS-1/TRAF6 s...
MBL and ficolins circulate as complexes with MBL-associated ...
MEK-ERK pathways are considered to be highly conserved. Thei...
MEKK1 can activate both IKK-alpha and IKK-beta in vivo[Lee F...
NLRX1 is a member of nucleotide-binding domain and leucine-r...
Once activated, IPS-1 recruits TRAFs (TNF receptor associate...
Phosphorylation and dimerization of IRF3 results in the cyto...
Poly(I)-poly(C) was reported to trigger MDA5 mediated IFN si...
Predicted chicken interferon beta promoter stimulator 1(IPS...
Predicted chicken autophagy protein 5 (Atg5) and autophagy-r...
Predicted chicken ITCH shows 86% amino acid sequence identit...
Predicted chicken NLRC5 shows 34% amino acid sequence identi...
Predicted chicken TBK1and IKK epsilon show 86% and 68% amino...
Strong up-regulation of IL-1beta but not type 1 interferons ...
Surface-bound C3b interacts with factor B which in turn is c...
TANK (TRAF family member-associated NF-kB activator) is a TR...
The complement system is the first line of defense against i...
The role of chicken lipopolysaccharide-binding protein (LBP)...
Thioester bond hydrolysis results in conformational changes ...
TLR15 induction was observed in chicken embryonic fibroblast...
TNF receptor associated factor (TRAF) protein family members...
Toll-like Receptor 4 is an evolutionarily conserved microbe ...
TRAFs are E3 ubiquitin ligases that bind to an E2 - ubiquiti...
TRAFs are E3 ubiquitin ligases that catalyse Lys63-polyubqui...
Upon binding of C7 to C5b:C6, the trimolecular C5b:C6:C7 com...
Vitronectin blocks MAC complex formation by inhibiting C9 po...
Author of entries
IKKs_complex (Inhibitor of kappa B kinases) [mitochondrial outer membrane]
p-IRAK2 : p-IRAK4 : activated TLR : MyD88 [plasma membrane]
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane]
'CD59 [plasma membrane]' negatively regulates 'C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC)'
'CREG(CR1L) binds to surface-bound C3 convertases' negatively regulates 'Cleavage of C3 by surface-bound C3 convertases'
'CREM (CREMP) binds to surface-bound C3b or C4b' negatively regulates 'Cleavage of C3 by surface-bound C3 convertases'
'dsRNA:MDA5:IPS1:TRADD:FADD:RIP1:caspase8 or 10 dimer:IKKcomplex [mitochondrial outer membrane]' positively regulates 'Phosphorylation of IKKs complex mediated by MEKK1'
'Hydrolysis of C4b' negatively regulates 'C4b binds to target cell surface'
'Mg2+ [extracellular region]' positively regulates 'Complement factor B binds to surface-bound C3b fragment'
'Mg2+ [extracellular region]' positively regulates 'Formation of C4b:C2 complex'
'NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding.' negatively regulates 'Activated MDA5 binds IPS-1'
'NLRX1 inhibits IPS1 signaling' negatively regulates 'Activated MDA5 binds IPS-1'
'viral dsRNA : TLR3 : TIKAM1 : RIP1 [endosome membrane]' positively regulates 'chicken RIP1 facilitates IKKs complex activation'
'Vitronectin binds to C5b-C7 complex' negatively regulates 'C5b:C6:C7 inserts into the target cell membrane'
'Vitronectin prevents C9 polymerization' negatively regulates 'C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC)'
Activated chicken TAK1 complexes [cytosol, plasma membrane]
Activated chicken TAK1 dissociates from the activated TLR3 complex [Gallus gallus]
activated IRAK4 [endosome membrane] UENBCdRHR
activated IRAK4 [plasma membrane] UENBCdRHR
Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2 [Gallus gallus, Salmonella typhimurium]
activated MAp19 [extracellular region] UENBCdRHR
activated MAp19 dimer [extracellular region]
activated MASP2 [extracellular region] UENBCdRHR
activated MASP2 dimer [extracellular region]
activated MASP2/3, MAp19 [extracellular region]
activated MASP3 [extracellular region] UENBCdRHR
activated MASP3 dimer [extracellular region]
Activated MDA5 binds IPS-1 [Gallus gallus]
Activated TAK1 leaves endosome membrane [Gallus gallus]
activated TBK1/IKK epsilon [mitochondrial outer membrane]
activated TLR : MyD88 : p-IRAK4 [plasma membrane]
activated TLR homodimer : MyD88 complex [plasma membrane]
activated TLR5 or 15 bound to ligand [plasma membrane]
Activated TLR5/TLR15 homodimer recruits MyD88 adaptor [Gallus gallus, Salmonella typhimurium]
Activation of C1r within the C1complement complex [Gallus gallus]
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation [Gallus gallus]
Anaphylatoxins initiate inflammatory responses [Gallus gallus]
Antigen bound antibody interacts with C1complement complex [Gallus gallus]
Antigen:IgM [plasma membrane]
Atg12 [cytosol] E
Atg12 [mitochondrial outer membrane] E
Atg5 [cytosol] UENBCdRHR
Atg5 [mitochondrial outer membrane] UENBCdRHR
Atg5-Atg12 conjugate [cytosol]
Atg5-Atg12 conjugate [mitochondrial outer membrane]
Autophosphorylation of IRAK4 bound to activated TLR5 or 15 [Gallus gallus, Salmonella typhimurium]
C-terminal C1r [extracellular region] U
C1Q molecule [extracellular region]
C1Q subunit [extracellular region]
C1q:activated C1r:activated C1s [extracellular region]
C1q:activated C1r:pro-C1s [extracellular region]
C1q:pro-C1r:pro-C1s [extracellular region]
C1QA [extracellular region] U
C1QB [extracellular region] U
C1QC [extracellular region] E
C1r activates C1s component within C1 complement complex [Gallus gallus]
C2 [extracellular region] U
C2b [extracellular region] U
C3 convertases [plasma membrane]
C3a [extracellular region] U
C3a anaphylatoxin binds C3a receptor [Gallus gallus]
C3a:C3AR1 [plasma membrane]
C3AR1 [plasma membrane] U
C3b [extracellular region]
C3b [plasma membrane]
C3b fragment binds to the target cell surface [Gallus gallus]
C3b/C4b [extracellular region]
C3b/C4b [plasma membrane]
C3b:Bb [plasma membrane]
C3b:C3b:Bb [plasma membrane]
C3b:factor B [plasma membrane]
C3c [extracellular region]
C3dg [plasma membrane]
C3dg fragment [extracellular region] U
C3f [extracellular region] U
C3i [extracellular region]
C3i:factor B [extracellular region]
C3i:factor Bb [extracellular region]
C4-1 derived C4a [extracellular region] U
C4-1 derived C4b [extracellular region] U
C4-2 derived C4a [extracellular region] U
C4-2 derived C4b [extracellular region] U
C4/C2 activator [plasma membrane]
C4a [extracellular region]
C4b [extracellular region]
C4b [plasma membrane]
C4b binds to target cell surface [Gallus gallus]
C4b:C2 [plasma membrane]
C4b:C2b [plasma membrane]
C4b:C2b:C3b [plasma membrane]
C5 convertases [plasma membrane]
C5a [extracellular region] U
C5a anaphylatoxin binds C5a receptor [Gallus gallus]
C5a:C5AR1 [plasma membrane]
C5AR1 [plasma membrane] E
C5b [extracellular region]
C5b [plasma membrane]
C5b fragment alpha chain [extracellular region] U
C5b fragment alpha chain [plasma membrane] U
C5b:C6 [extracellular region]
C5b:C6:C7 [extracellular region]
C5b:C6:C7 [plasma membrane]
C5b:C6:C7 inserts into the target cell membrane [Gallus gallus]
C5b:C6:C7:C8 [plasma membrane]
C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) [Gallus gallus]
C6 [extracellular region] U
C6 [plasma membrane] U
C7 [extracellular region] U
C7 [plasma membrane] U
C8 [extracellular region]
C8 [plasma membrane]
C8 binds to C5b:C6:C7 complement complex [Gallus gallus]
C8A [extracellular region] U
C8A [plasma membrane] U
C8B [extracellular region] U
C8B [plasma membrane] U
C8G [extracellular region] U
C8G [plasma membrane] U
C9 [extracellular region]
C9 [plasma membrane]
Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization [Gallus gallus]
Caspase-8 and -10 mediated induction of NF-kB [Gallus gallus]
CD59 [plasma membrane]
CD59 binds C5b:C6:C7:C8 [Gallus gallus]
CD59:C5b:C6:C7:C8:C9 [plasma membrane]
Cell-surface carbohydrates [plasma membrane]
CFH [extracellular region] U
CFH:C3b [extracellular region]
CFH:C3b [plasma membrane]
CFI [extracellular region] U
ch p-IRAK4 bound to the activated TLR complex [plasma membrane]
CHF [plasma membrane]
chicken TAB2/TAB3 [cytosol]
chicken TAB2/TAB3 [endosome membrane]
chicken TAB2/TAB3 [plasma membrane]
chTRAF6 bound to the activated chicken TLR complex [plasma membrane]
Classical antibody-mediated complement activation [Gallus gallus]
Cleavage of C2 to form classical C3 convertase [Gallus gallus]
Cleavage of C3 by fluid-phase C3i:factor B [Gallus gallus]
Cleavage of C3 by surface-bound C3 convertases [Gallus gallus]
Cleavage of C5 by C5 convertases [Gallus gallus]
Cleavage of surface-bound factor B [Gallus gallus]
Complement C3 alpha chain [extracellular region] U
Complement C3 beta chain [extracellular region] U
Complement C3b fragment alpha chain [extracellular region] U
Complement C3c alpha chain fragment 1 [extracellular region] U
Complement C3c alpha chain fragment 2 [extracellular region] U
complement C4-1 [extracellular region] U
complement C4-2 [extracellular region] U
complement C5 alpha chain [extracellular region] U
complement C5 beta chain [extracellular region] U
complement C5 beta chain [plasma membrane] U
Complement Cascade [Gallus gallus]
Complement factor B binds to surface-bound C3b fragment [Gallus gallus]
Complement factor B binds to the hydrolyzed form of C3 [Gallus gallus]
complement factor C3 [extracellular region]
complement factor C4 [extracellular region]
complement factor C5 [extracellular region]
complement factor D [extracellular region]
Complement factor H binds to C3b [Gallus gallus]
Complement factor H binds to surface-bound C3b [Gallus gallus]
Complement factor I inactivates C3b [Gallus gallus]
Complement factor I inactivates surface-bound C3b [Gallus gallus]
Complement iC3b alpha chain fragment 1 [extracellular region] U
Complement iC3b alpha chain fragment 2 [extracellular region] U
Creation of alternative pathway C3 convertase [Gallus gallus]
Creation of classical C3 convertase [Gallus gallus]
CREG (CR1L) causes dissociation of C3 convertases [Gallus gallus]
CREG [plasma membrane] UENBCdRHR
CREG(CR1L) binds to surface-bound C3 convertases [Gallus gallus]
CREG:C3 convertases [plasma membrane]
CREG:C3b [plasma membrane]
CREG:C3b:Bb [plasma membrane]
CREG:C4b [plasma membrane]
CREG:C4b:C2b [plasma membrane]
CREM (CREMP) binds to surface-bound C3b or C4b [Gallus gallus]
CREM:C3b/C4b [plasma membrane]
CREMP [plasma membrane] UENBCdRHR
deamidated L-glutamine at 1005
Dihydroxyacetone kinase (DAK) [cytosol] E
dsRNA binds to MDA5 [Gallus gallus]
dsRNA:MDA5 homodimer [cytosol]
dsRNA:MDA5 homodimer [mitochondrial outer membrane]
dsRNA:MDA5 homodimer:NLRC5 [cytosol]
dsRNA:MDA5:Atg5-Atg12:IPS1 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K48-pUb [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63 pUb-TRAF3/ or TRAF6:TANK [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63 pUb-TRAF3/or TRAF6:TANK:activated TBK1/IKK epsilon [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63 pUb-TRAF3/or TRAF6:TANK:activated TBK1/or IKK epsilon: IRF3 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63-linked polyubiquitin TRAF3/ or TRAF6 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63-linked pUb TRAF6 or TRAF2 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63-pUb-TRAF2 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63-pUb-TRAF3 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63-pUb-TRAF6 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:K63-pUb-TRAF6/or TRAF2:MEKK1 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRADD:FADD:RIP1 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRADD:FADD:RIP1:caspase8 or 10 dimer:IKKcomplex [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRADD:FADD:RIP1:procaspase 8 or 10 dimer [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRAF2 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRAF3 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRAF3/ or TRAF6 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRAF3/ or TRAF6 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRAF6 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRAF6/or TRAF2 [mitochondrial outer membrane]
dsRNA:MDA5:IPS1:TRAF6/TRAF2 [mitochondrial outer membrane]
factor B [extracellular region] U
factor Ba [extracellular region] U
factor Bb [extracellular region] U
Factor H binds to host cell surface [Gallus gallus]
Factor H displaces Bb in Cb:Bb complex [Gallus gallus]
FADD [cytosol] E
FADD [mitochondrial outer membrane] E
Ficolin [extracellular region] E
Ficolin subunit [extracellular region]
Ficolin tetramer [extracellular region]
ficolin:MASPs [extracellular region]
Flagellin (phase 2 - flagellin) [plasma membrane] U
Flagellin (phase1- flagellin) [plasma membrane] U
Flagellin -phase1 and/or 2 [plasma membrane]
Fluid-phase proteolytic cleavage of factor B [Gallus gallus]
Formation of alternate C5 convertase [Gallus gallus]
Formation of C4b:C2 complex [Gallus gallus]
Formation of C5b:C6 [Gallus gallus]
Formation of C5b:C6:C7 [Gallus gallus]
Formation of classical C5 convertase [Gallus gallus]
Formation of fluid-phase convertase C3 [Gallus gallus]
Formation of membrane attack complex (MAC) [Gallus gallus]
Formation of membrane-bound convertase C3 [Gallus gallus]
hydrolysed C4b [extracellular region]
Hydrolysis of C4b [Gallus gallus]
iC3b [extracellular region]
iC3b [plasma membrane]
iC3b proteolysis [Gallus gallus]
Ig heavy chain [extracellular region]
Ig heavy chain VH1 [extracellular region] U
Ig lambda chain C region [extracellular region] UE
Ig lambda chain V-1 region [extracellular region] UE
Ig mu chain C region [extracellular region] U
IGJ [extracellular region] E
IgM [extracellular region]
IgM pentamer [extracellular region]
IgM:Antigen:C1q:C1r:pro-C1s [plasma membrane]
IgM:Antigen:C1q:pro-C1r:pro-C1s [plasma membrane]
IgM:Antigen:Cqrs(activated C1r and C1s) [plasma membrane]
IKBKB(IKK_beta) [mitochondrial outer membrane] UENBCdR
Immunoglobulin Lambda [extracellular region]
Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate [Gallus gallus]
Inhibitor of NF kappa B kinase(IKKA)_subunit alpha [mitochondrial outer membrane] UENBCdRHR
Innate Immune System [Gallus gallus]
Intra-chain Crosslink via S-(L-isoglutamyl)-L-cysteine at 1002 and 1005
IPS-1 [mitochondrial outer membrane] UENBCdRHR
IPS1 interacts with TRADD, RIP1 and FADD [Gallus gallus]
IPS1: NLRX1 [mitochondrial outer membrane]
IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane]
IRAK2 [endosome membrane] UENBCdRHR
IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex [Gallus gallus, Salmonella typhimurium]
IRAK4 [endosome membrane] UENBCdRHR
IRF3 [mitochondrial outer membrane] UENBCdRHR
ITCH [cytosol] U
ITCH homolog downregulates MDA5/IPS1 signaling [Gallus gallus]
K48- Ubiquitin [cytosol]
K48- Ubiquitin [mitochondrial outer membrane]
K48-linked polyubiquitin chain [cytosol]
K48-linked polyubiquitin chain [mitochondrial outer membrane]
K48-ubiquitin (RPS27A) [cytosol] UENBCdRHR
K48-ubiquitin (RPS27A) [mitochondrial outer membrane] UENBCdRHR
K48-ubiquitin (UBB 1) [cytosol] U
K48-ubiquitin (UBB 1) [mitochondrial outer membrane] U
K48-ubiquitin (UBB 2) [cytosol] U
K48-ubiquitin (UBB 2) [mitochondrial outer membrane] U
K48-ubiquitin (UBB 3) [cytosol] U
K48-ubiquitin (UBB 3) [mitochondrial outer membrane] U
K48-ubiquitin (UBB 4) [cytosol] U
K48-ubiquitin (UBB 4) [mitochondrial outer membrane] U
K63 -polyubiquitinated TRAF2 [mitochondrial outer membrane]
K63 -polyubiquitinated TRAF3 [mitochondrial outer membrane]
K63 -polyubiquitinated TRAF6 [mitochondrial outer membrane]
K63 polyubiquitin chain [mitochondrial outer membrane]
K63 polyubiquitin chain [plasma membrane]
K63-linked Ub TRAF6 [plasma membrane] U
K63-Ub-TRAF2 [mitochondrial outer membrane] U
K63-Ub-TRAF3 [mitochondrial outer membrane] E
K63-Ub-TRAF6 [mitochondrial outer membrane] U
K63-ubiquitin (RPS27A) [mitochondrial outer membrane] UENBCdRHR
K63-ubiquitin (RPS27A) [plasma membrane] UENBCdRHR
K63-ubiquitin (UBA52) [mitochondrial outer membrane] U
K63-ubiquitin (UBA52) [plasma membrane] U
K63-ubiquitin (UBB 1) [mitochondrial outer membrane] U
K63-ubiquitin (UBB 1) [plasma membrane] U
K63-ubiquitin (UBB 2) [mitochondrial outer membrane] U
K63-ubiquitin (UBB 2) [plasma membrane] U
K63-ubiquitin (UBB 3) [mitochondrial outer membrane] U
K63-ubiquitin (UBB 3) [plasma membrane] U
K63-ubiquitin (UBB 4) [mitochondrial outer membrane] U
K63-ubiquitin (UBB 4) [plasma membrane] U
K63-Ubiquitin [mitochondrial outer membrane]
K63_Ubiquitin [plasma membrane]
Lectin-mediated initiation of complement cascade [Gallus gallus]
Ligand recognized by chicken TLR15 [plasma membrane]
MAC [plasma membrane]
MAp19 [extracellular region] UENBCdRHR
MAp19 dimer [extracellular region]
MASP2 [extracellular region] UENBCdRHR
MASP2 dimer [extracellular region]
MASP2/3, MAp19 [extracellular region]
MASP3 [extracellular region] UENBCdRHR
MASP3 dimer [extracellular region]
MASPs activation [Gallus gallus]
MBL [extracellular region] UENBCdRHR
MBL or ficolin binds an oligosaccharide pattern on the target cell surface [Gallus gallus]
MBL subunit [extracellular region]
MBL triple helix [extracellular region]
MBL/ficolin:MASPs [extracellular region]
MBL:MASPs [extracellular region]
MDA-5 [cytosol] U
MDA-5 [mitochondrial outer membrane] U
MDA5 : DAK [cytosol]
MEKK1 [cytosol] E
MEKK1 [mitochondrial outer membrane] E
MEKK1 binds TRAF6 [Gallus gallus]
MyD88 cascade initiated on plasma membrane [Gallus gallus, Salmonella typhimurium]
N-terminal C1r [extracellular region] U
Negative Regulation of MDA5 signaling [Gallus gallus]
NLRC5 [cytosol] E
NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. [Gallus gallus]
NLRX1 inhibits IPS1 signaling [Gallus gallus]
NLRX1 like [mitochondrial outer membrane] U
O-phospho-L-serine at unknown position
O-phospho-L-threonine at unknown position
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane]
oligo TRAF6 : p-IRAK2 [endosome membrane]
Opsonization with C3b or C4b [Gallus gallus]
p-IRAK2 bound to the activated chicken TLR complex [plasma membrane]
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [cytosol]
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane]
phospho IKK epsilon [mitochondrial outer membrane] E
phospho-TBK1 [mitochondrial outer membrane] E
phosphorylated IRAK2 [endosome membrane] UENBCdRHR
phosphorylated TAK1 [plasma membrane] E
Phosphorylation and release of IRF3 [Gallus gallus]
Phosphorylation of IKKs complex mediated by MEKK1 [Gallus gallus]
pro-(C1s:C1r:C1r:C1s) [extracellular region]
pro-C1r [extracellular region] U
pro-C1s [extracellular region] UENBCdRHR
pro-C1s:C1r:C1r:pro-C1s [extracellular region]
procaspase 10 [cytosol] E
procaspase 10 [mitochondrial outer membrane] E
procaspase 10 dimer [mitochondrial outer membrane]
procaspase 8 [cytosol] UENBCdRHR
procaspase 8 [mitochondrial outer membrane] UENBCdRHR
procaspase 8 dimer [mitochondrial outer membrane]
procaspase 8 or 10 [cytosol]
procaspase 8/10 dimer [mitochondrial outer membrane]
processed C1r [extracellular region]
protein kinase activity of dsRNA:MDA5:IPS1:K63 pUb-TRAF3/or TRAF6:TANK:activated TBK1/or IKK epsilon: IRF3 [mitochondrial outer membrane]
protein kinase activity of dsRNA:MDA5:IPS1:K63-pUb-TRAF6/or TRAF2:MEKK1 [mitochondrial outer membrane]
protein serine/threonine kinase activity of IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane]
protein serine/threonine kinase activity of IRAK4 : MyD88 : activated TLR5 or TLR15 [plasma membrane]
protein serine/threonine kinase activity of p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane]
Proteolytic cleavage of complement factor C4 [Gallus gallus]
pUB-TRAF6:TAB2:TAB3:TAB1:free K63-pUb chain:phospho TAK1 [cytosol]
Recruitment of IKK complex [Gallus gallus]
Recruitment of IRF to activated TBK1/IKK epsilon [Gallus gallus]
Regulation of complement cascades [Gallus gallus]
RIP1 [mitochondrial outer membrane] UENBCdRHR
RLR (RIG-like receptor) mediated induction of IFN alpha/beta [Gallus gallus]
serine-type endopeptidase activity of C3 convertases [plasma membrane]
serine-type endopeptidase activity of C3i:factor Bb [extracellular region]
serine-type endopeptidase activity of C4/C2 activator [plasma membrane]
serine-type endopeptidase activity of C5 convertases [plasma membrane]
serine-type endopeptidase activity of CFI [extracellular region]
serine-type endopeptidase activity of complement factor D [extracellular region]
serine-type endopeptidase activity of IgM:Antigen:C1q:C1r:pro-C1s [plasma membrane]
serine-type endopeptidase activity of IgM:Antigen:C1q:pro-C1r:pro-C1s [plasma membrane]
SIKE-1 [cytosol] UENBCdRHR
Spontaneous hydrolysis of an internal thioester bond in complement factor C3 [Gallus gallus]
surface-bound C3 convertases [plasma membrane]
surface-bound ficolin:Ca2+:activated MASP [plasma membrane]
surface-bound ficolin:Ca2+:MASP [plasma membrane]
surface-bound lectin:Ca2+:activated MASPs [plasma membrane]
surface-bound lectins:Ca2+:MASPs [plasma membrane]
surface-bound MBL:Ca2+:activated MASP [plasma membrane]
surface-bound MBL:Ca2+:MASP [plasma membrane]
TAB1 [plasma membrane] UENBCdRHR
TAB2 [plasma membrane] E
TAB3 [plasma membrane] E
TAK1 : TAB1 : TAB2/TAB3 [plasma membrane]
TAK1 [plasma membrane] E
TANK [cytosol] U
TANK [mitochondrial outer membrane] U
TANK binds polyubiquitinated TRAF3/6 [Gallus gallus]
TBK1/IKK epsilon [cytosol]
TBK1/IKK epsilon : SIKE-1 [cytosol]
TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation [Gallus gallus]
thioester-hydrolyzed complement C3 alpha chain [extracellular region] U
TRADD [cytosol] E
TRADD [mitochondrial outer membrane] E
TRAF mediated activation of IRF [Gallus gallus]
TRAF2 [cytosol] U
TRAF2 [mitochondrial outer membrane] U
TRAF3 [cytosol] E
TRAF3 [mitochondrial outer membrane] E
TRAF3/or TRAF6 interacts with IPS-1 [Gallus gallus]
TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex [Gallus gallus]
TRAF3/TRAF6 [cytosol]
TRAF3/TRAF6 [mitochondrial outer membrane]
TRAF6 [mitochondrial outer membrane] U
TRAF6 [plasma membrane] U
TRAF6 mediated NF-kB activation [Gallus gallus]
TRAF6/or TRAF2 interacts with IPS-1 [Gallus gallus]
TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex [Gallus gallus]
TRAF6/TRAF2 [cytosol]
TRAF6/TRAF2 [mitochondrial outer membrane]
TRAF6:p-IRAK2 [endosome membrane]
ubiquitin (UBA52) [mitochondrial outer membrane] U
ubiquitin-ubiquitin ligase activity of dsRNA:MDA5:IPS1:TRAF3/ or TRAF6 [mitochondrial outer membrane]
ubiquitin-ubiquitin ligase activity of dsRNA:MDA5:IPS1:TRAF6/TRAF2 [mitochondrial outer membrane]
ubiquitin-ubiquitin ligase activity of ITCH [cytosol]
ubiquitinylated lysine at 124
ubiquitinylated lysine at 200
ubiquitinylated lysine at 276
ubiquitinylated lysine at 48
ubiquitinylated lysine at 48
ubiquitinylated lysine at unknown position
ubiquitinylated lysine at unknown position
ubiquitinylated lysine at unknown position
Viral dsRNA (-) Stranded [mitochondrial outer membrane]
Vitronectin binds to C5b-C7 complex [Gallus gallus]
Vitronectin prevents C9 polymerization [Gallus gallus]
VTN [extracellular region] UENBCdRHR
VTN:C5b-C9 [extracellular region]
VTN:C5b:C6:C7 [extracellular region]