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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:49566
_displayNameUniProt:P62736 ACTA2
_timestamp2014-11-19 11:04:00
checksum2D0543262DB35CA5
commentFUNCTION Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.SUBUNIT Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.DISEASE ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery disease (CAD), premature ischemic strokes and Moyamoya disease.MISCELLANEOUS In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
crossReference[DatabaseIdentifier:6573101] PRO:P62736
[DatabaseIdentifier:6612584] GeneCards:P62736
[DatabaseIdentifier:6637127] UCSC human:P62736
[DatabaseIdentifier:6647040] RefSeq:NP_001604
descriptionrecommendedName: Actin, aortic smooth muscle alternativeName: Alpha-actin-2 alternativeName: Cell growth-inhibiting gene 46 protein
geneNameACTA2
ACTSA
ACTVS
GIG46
identifierP62736
isSequenceChangedFALSE
keywordAcetylation
Aortic aneurysm
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Methylation
Muscle protein
Nucleotide-binding
Oxidation
Polymorphism
Reference proteome
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:6348073] Croft, D
[InstanceEdit:6378953] Croft, D
[InstanceEdit:6410971] Croft, D
[InstanceEdit:6442989] Croft, D
[InstanceEdit:6475007] Croft, D
[InstanceEdit:6507025] Croft, D
[InstanceEdit:6609128] Croft, D
[InstanceEdit:6626660] Croft, D
[InstanceEdit:6633671] Croft, D
[InstanceEdit:6641434] Croft, D
[InstanceEdit:6672501] Croft, D
[InstanceEdit:6688369] Croft, D
nameACTA2
otherIdentifier0000380273
11722352_s_at
16716350
200974_at
237522_at
32755_at
3299506
3299507
3299508
3299513
3299517
3299520
3299521
3299531
3299532
3299534
3299540
44618_at
59
7934906
A_23_P150053
AAA51577
AAA60560
AAH17554
AAH93052
AAW29811
AAX82248
AAX82249
ACT
ACTA2
ACTA2-001
ACTA2-201
ACZ58370
AK056592
AK300664
AK313294
AL157394
AY692464
AY970439
AY970440
B3KPP5
B4DUI8
BAG36101
BAG51757
BAG62350
BC017554
BC093052
CAA32064
CAB000002
CAB013531
CAG38756
CAI13864
CCDS7392
CH471066
CR536518
D2JYH4
EAW50153
EAW50154
EAW50155
ENSG00000107796
ENSP00000224784
ENSP00000402373
ENST00000224784
ENST00000458208
EntrezGene:59
F6QUT6
F6UVQ4
g4501882_3p_s_at
GU143396
HGNC:130
HPA041264
HPA041271
Hs.33654.0.A1_3p_at
Hs.500483
Hs.635256
ILMN_1671703
IPR004000
J05192
K01741
K01742
K01743
M33216
MIM:102620
MIM:611788
MIM:613834
MIM:614042
NM_001141945
NM_001613
NP_001135417
NP_001604
OTTHUMP00000020042
PF00022
PH_hs_0043711
PR00190
Q562S2
SM00268
TC10001498.hg
uc001kfp.3
uc001kfq.3
UPI0000000E0F
X13839
X13839_at
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6693577] KEGG Gene:59 actin, alpha 2, smooth muscle, aorta [Homo sapiens]
[ReferenceDNASequence:6353569] ENSEMBL:ENSG00000107796 [Homo sapiens]
[ReferenceDNASequence:6384420] NCBI Gene:59 [Homo sapiens]
[ReferenceDNASequence:6421060] BioGPS Gene:59 [Homo sapiens]
[ReferenceDNASequence:6453078] CTD Gene:59 [Homo sapiens]
[ReferenceDNASequence:6485096] dbSNP Gene:59 [Homo sapiens]
[ReferenceDNASequence:6630295] OMIM:102620 [Homo sapiens]
[ReferenceDNASequence:6699997] Orphanet:16835 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6680631] RefSeq:NM_001613
secondaryIdentifierACTA_HUMAN
B2R8A4
P03996
P04108
Q6FI19
sequenceLength377
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:445792] ACTA2 [cytosol] [Homo sapiens]
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