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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:49566
_displayNameUniProt:P62736 ACTA2
_timestamp2014-05-28 17:17:35
checksum2D0543262DB35CA5
commentFUNCTION Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.SUBUNIT Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.MISCELLANEOUS In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.SIMILARITY Belongs to the actin family.
crossReference[DatabaseIdentifier:6443518] GeneCards:P62736
[DatabaseIdentifier:6457831] UCSC human:P62736
[DatabaseIdentifier:6467374] RefSeq:NP_001604
descriptionrecommendedName: Actin, aortic smooth muscle alternativeName: Alpha-actin-2 alternativeName: Cell growth-inhibiting gene 46 protein
geneNameACTA2
ACTSA
ACTVS
GIG46
identifierP62736
isSequenceChangedFALSE
keywordAcetylation
Aortic aneurysm
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Methylation
Muscle protein
Nucleotide-binding
Oxidation
Polymorphism
Reference proteome
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:6281038] Croft, D
[InstanceEdit:6311957] Croft, D
[InstanceEdit:6343996] Croft, D
[InstanceEdit:6376035] Croft, D
[InstanceEdit:6408074] Croft, D
[InstanceEdit:6440113] Croft, D
[InstanceEdit:6447579] Croft, D
[InstanceEdit:6454426] Croft, D
[InstanceEdit:6461892] Croft, D
[InstanceEdit:6492909] Croft, D
[InstanceEdit:6508136] Croft, D
nameACTA2
otherIdentifierENSG00000107796
ENST00000224784
ENSP00000224784
200974_at
32755_at
X13839_at
g4501882_3p_s_at
A_23_P150053
A_32_P318882
CCDS7392
AL157394
K01747
K01741
K01742
K01743
K01744
K01745
K01746
AY970439
AY970440
X13839
J05192
AY692464
CR536518
BC017554
BC093052
M33216
EntrezGene:59
GI_4501882-S
ILMN_6588
IPI00008603
IPI00645534
IPI00816229
MIM:102620
OTTHUMT00000049264
CAI13865
AAA51586
AAX82248
AAX82249
CAA32064
AAA51577
AAW29811
CAG38756
CAI13864
AAH17554
AAH93052
AAA60560
NM_001613
NP_001604
Q5T9N7
Q13707
Q562S2
P62736
Q5T9N7_HUMAN
Q13707_HUMAN
Q562S2_HUMAN
ACTA_HUMAN
IPR004000
IPR004001
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6513281] KEGG Gene:59 actin, alpha 2, smooth muscle, aorta [Homo sapiens]
[ReferenceDNASequence:6286509] ENSEMBL:ENSG00000107796 [Homo sapiens]
[ReferenceDNASequence:6317410] NCBI Gene:59 [Homo sapiens]
[ReferenceDNASequence:6354117] BioGPS Gene:59 [Homo sapiens]
[ReferenceDNASequence:6386156] CTD Gene:59 [Homo sapiens]
[ReferenceDNASequence:6418195] dbSNP Gene:59 [Homo sapiens]
[ReferenceDNASequence:6451121] OMIM:102620 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6500707] RefSeq:NM_001613
secondaryIdentifierACTA_HUMAN
B2R8A4
P03996
P04108
Q6FI19
sequenceLength377
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:445792] ACTA2 [cytosol] [Homo sapiens]
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