instancebrowser | sectioned | sidebarwithdynamichierarchy
Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:49566
_displayNameUniProt:P62736 ACTA2
_timestamp2014-09-11 06:46:54
checksum2D0543262DB35CA5
commentFUNCTION Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.SUBUNIT Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.MISCELLANEOUS In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.SIMILARITY Belongs to the actin family.
crossReference[DatabaseIdentifier:6582082] PRO:P62736
[DatabaseIdentifier:6622383] GeneCards:P62736
[DatabaseIdentifier:6646571] UCSC human:P62736
[DatabaseIdentifier:6656302] RefSeq:NP_001604
descriptionrecommendedName: Actin, aortic smooth muscle alternativeName: Alpha-actin-2 alternativeName: Cell growth-inhibiting gene 46 protein
geneNameACTA2
ACTSA
ACTVS
GIG46
identifierP62736
isSequenceChangedFALSE
keywordAcetylation
Aortic aneurysm
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Methylation
Muscle protein
Nucleotide-binding
Oxidation
Polymorphism
Reference proteome
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:6348050] Croft, D
[InstanceEdit:6379983] Croft, D
[InstanceEdit:6413044] Croft, D
[InstanceEdit:6446105] Croft, D
[InstanceEdit:6479166] Croft, D
[InstanceEdit:6512227] Croft, D
[InstanceEdit:6618954] Croft, D
[InstanceEdit:6636231] Croft, D
[InstanceEdit:6643142] Croft, D
[InstanceEdit:6650745] Croft, D
[InstanceEdit:6682804] Croft, D
[InstanceEdit:6698332] Croft, D
nameACTA2
otherIdentifierAK300664
HPA041264
16716350
Hs.635256
OTTHUMP00000020042
ENSP00000224784
0000380273
K01743
EAW50154
K01742
B4DUI8
7934906
AY970440
3299506
ACTA2
AAH93052
AK313294
AAX82248
3299527
MIM:102620
2398629
PR00190
Q562S2
UPI0000000E0F
BC093052
uc001kfp.3
CAB013531
MIM:614042
CAA32064
AY692464
AAW29811
X13839
AAA60560
3299521
MIM:611788
AAX82249
CAI13864
3299513
3299534
BAG51757
AAH17554
EAW50153
3299520
3299517
3299531
CCDS7392
SM00268
D2JYH4
BAG36101
ILMN_1671703
NP_001604
Hs.500483
AK056592
EntrezGene:59
A_23_P150053
11722352_s_at
HGNC:130
CAB000002
ACZ58370
59
CH471066
ACT
IPR004000
AL157394
BAG62350
ENSG00000107796
F6UVQ4
EAW50155
F6QUT6
NM_001613
3299508
X13839_at
HPA041271
32755_at
g4501882_3p_s_at
CR536518
CAG38756
ACTA2-001
K01741
PF00022
3299540
3299532
200974_at
AY970439
MIM:613834
B3KPP5
AAA51577
J05192
3299507
BC017554
M33216
GU143396
PH_hs_0043711
NP_001135417
ACTA2-201
237522_at
NM_001141945
Hs.33654.0.A1_3p_at
44618_at
uc001kfq.3
ENSP00000402373
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6703507] KEGG Gene:59 actin, alpha 2, smooth muscle, aorta [Homo sapiens]
[ReferenceDNASequence:6353586] ENSEMBL:ENSG00000107796 [Homo sapiens]
[ReferenceDNASequence:6385509] NCBI Gene:59 [Homo sapiens]
[ReferenceDNASequence:6423347] BioGPS Gene:59 [Homo sapiens]
[ReferenceDNASequence:6456408] CTD Gene:59 [Homo sapiens]
[ReferenceDNASequence:6489469] dbSNP Gene:59 [Homo sapiens]
[ReferenceDNASequence:6639802] OMIM:102620 [Homo sapiens]
[ReferenceDNASequence:6722547] Orphanet:16835 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6690756] RefSeq:NM_001613
secondaryIdentifierACTA_HUMAN
B2R8A4
P03996
P04108
Q6FI19
sequenceLength377
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:445792] ACTA2 [cytosol] [Homo sapiens]
[Change default viewing format]