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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P78536
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Disintegrin and metalloproteinase domain-containing protein 17 shortName:ADAM 17 ecNumber3.4.24.86/ecNumber alternativeName: Snake venom-like protease alternativeName: TNF-alpha convertase alternativeName: TNF-alpha-converting enzyme cdAntigenNameCD156b/cdAntigenName
Links to corresponding entries in other databasesBioGPS Gene:6868
Brenda:3.4.24.86
CTD Gene:6868
DOCK Blaster:1BKC
DOCK Blaster:1ZXC
DOCK Blaster:2A8H
DOCK Blaster:2DDF
DOCK Blaster:2FV9
EC:3.4.24.86
ENSEMBL:ENSG00000151694
GeneCards:P78536
HapMap:NM_003183
IntEnz:3.4.24.86
KEGG Gene:6868
NCBI Gene:6868
OMIM:603639
Protein Data Bank:1BKC
Protein Data Bank:1ZXC
Protein Data Bank:2A8H
Protein Data Bank:2DDF
Protein Data Bank:2FV9
RefSeq:NM_003183
RefSeq:NP_003174
UCSC human:P78536
UniProt:P78536
dbSNP Gene:6868
Other identifiers related to this sequenceADA17_HUMAN, O60226, ENSG00000151694, ENST00000310823, ENSP00000309968, 1226_at, 1227_g_at, 205746_s_at, 205745_x_at, 213532_at, 230621_at, 41601_at, U86755_s_at, U69611_at, Hs.52438.1.A1_3p_at, g11497003_3p_a_at, g1857672_3p_a_at, Hs.52438.0.S1_3p_at, Hs.64311.2.A1_3p_at, A_14_P138599, A_23_P143120, A_32_P129621, A_32_P806252, CCDS1665, GE59572, AC080162, AC092206, AC073195, BC062687, U86755, U69611, U69612, U92649, EntrezGene:6868, GI_11497005-A, ILMN_5977, IPI00029606, IPI00288894, MIM:603639, 1BKC, 1ZXC, 2A8H, 2DDF, 2FV9, AAX93091, AAX93142, AAH62687, AAY14859, AAB51586, AAB51514, AAB53014, AAC39721, NM_003183, NP_003174, OTTHUMT00000206857, Hs.404914, Q53RF5, Q53S40, Q6P5T8, Q53RS1, P78536, Q53RF5_HUMAN, Q53S40_HUMAN, Q6P5T8_HUMAN, Q53RS1_HUMAN, ADA17_HUMAN, P78536-2, IPR006025, IPR001590, IPR001762
Molecules with this sequenceADAM17 [plasma membrane] UKENBCdORHGURPPPPPDDDDD
Component ofADAM 17 metalloprotease (Zn cofactor) [plasma membrane]
ADAM17 [plasma membrane]
ADAM:Zn2+ [plasma membrane]
Represented by generalisation(s)ADAM metalloprotease [plasma membrane]
Collagen type XVII sheddases [plasma membrane]
ADAM10/17 [plasma membrane]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Shh is released from the plasma membrane by ADAM17-mediated cleavage [Homo sapiens]

Apoptosis

Disease

ADAM17 cleaves Notch1 at S2 [Mus musculus]

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Immune System

Extracellular matrix organization

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