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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P78536
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Disintegrin and metalloproteinase domain-containing protein 17 shortName:ADAM 17 ecNumber3.4.24.86/ecNumber alternativeName: Snake venom-like protease alternativeName: TNF-alpha convertase alternativeName: TNF-alpha-converting enzyme cdAntigenNameCD156b/cdAntigenName
Links to corresponding entries in other databasesBioGPS Gene:6868
Brenda:3.4.24.86
CTD Gene:6868
DOCK Blaster:1BKC
DOCK Blaster:1ZXC
DOCK Blaster:2A8H
DOCK Blaster:2DDF
DOCK Blaster:2FV9
EC:3.4.24.86
ENSEMBL:ENSG00000151694
GeneCards:P78536
HapMap:NM_003183
IntEnz:3.4.24.86
KEGG Gene:6868
NCBI Gene:6868
OMIM:603639
Orphanet:21088
PRO:P78536
Protein Data Bank:1BKC
Protein Data Bank:1ZXC
Protein Data Bank:2A8H
Protein Data Bank:2DDF
Protein Data Bank:2FV9
RefSeq:NM_003183
RefSeq:NP_003174
UCSC human:P78536
UniProt:P78536
dbSNP Gene:6868
Other identifiers related to this sequenceADA17_HUMAN, O60226, 2539841, 11731110_at, 213532_at, 2539822, 3O64, 2539834, 11747645_a_at, 3LEA, ILMN_1765779, OTTHUMP00000115493, 0003850411, A_23_P143120, A_32_P129621, 2539828, 2539829, 1226_at, AAB53014, 2FV9, MIM:603639, 41601_at, 205746_s_at, 2539849, IPR002870, CAB025906, 2M2F, 3KME, AAX93091, ILMN_2121068, 2539855, Q53S40, 2539850, g1857672_3p_a_at, U92649, 3LGP, ENSG00000151694, g11497003_3p_a_at, 2539823, 2539846, 2539836, 3EDZ, AC080162, AC073195, U86755, 1227_g_at, uc002qzu.4, 9034190, 3L0V, 2539838, GQ402545, PF00200, IPR001762, 2539835, EntrezGene:6868, ACV30013, PF01562, 3L0T, BC136783, 8050190, 3G42, 2539825, Hs.404914, 2FV5, UPI00001254D4, HPA051575, CCDS1665, 2539857, ENSP00000309968, 3B92, NM_003183, 9574564, AAI36784, AAC39721, CH471053, Hs.52438.1.A1_3p_at, 2539833, 2A8H, U69611, PH_hs_0024641, 11731109_a_at, 2539824, 2OI0, EAX00982, AAB51586, MIM:614328, AAX93142, U86755_s_at, AC092206, 1BKC, 3LE9, 16894335, SM00050, 205745_x_at, GE59572, PF01421, 2539826, 2539852, 2I47, 2539856, 1ZXC, 6868, 2539840, 3E8R, 3KMC, 2DDF, HGNC:195, HPA010738, Q53RF5, NP_003174, U69611_at, 2539839, U69612, IPR001590, ADAM17, 3CKI, B2RNB2, AAB51514, 2539844, AAY14859, A_24_P157053, Q53RS1, 3EWJ, ADAM17-001
Molecules with this sequenceADAM17 [plasma membrane] UKENBCdOORHPGPPPPPURDDDDD
Component ofADAM 17 metalloprotease (Zn cofactor) [plasma membrane]
ADAM17 [plasma membrane]
ADAM:Zn2+ [plasma membrane]
Represented by generalisation(s)ADAM metalloprotease [plasma membrane]
Collagen type XVII sheddases [plasma membrane]
ADAM10/17 [plasma membrane]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Shh is released from the plasma membrane by ADAM17-mediated cleavage [Homo sapiens]

Apoptosis

Disease

ADAM17 cleaves Notch1 at S2 [Mus musculus]

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Immune System

Extracellular matrix organization

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