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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:Q06187
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein kinase BTK ecNumber2.7.10.2/ecNumber alternativeName: Agammaglobulinemia tyrosine kinase shortName:ATK alternativeName: B-cell progenitor kinase shortName:BPK alternativeName: Bruton tyrosine kinase
Links to corresponding entries in other databasesBioGPS Gene:695
Brenda:2.7.10.2
CTD Gene:695
DOCK Blaster:1AWW
DOCK Blaster:1AWX
DOCK Blaster:1B55
DOCK Blaster:1BTK
DOCK Blaster:1BWN
DOCK Blaster:1K2P
DOCK Blaster:1QLY
EC:2.7.10.2
ENSEMBL:ENSG00000010671
GeneCards:Q06187
HapMap:NM_000061
IntEnz:2.7.10.2
KEGG Gene:695
NCBI Gene:695
OMIM:300300
OMIM:307200
Orphanet:15383
PRO:Q06187
Protein Data Bank:1AWW
Protein Data Bank:1AWX
Protein Data Bank:1B55
Protein Data Bank:1BTK
Protein Data Bank:1BWN
Protein Data Bank:1K2P
Protein Data Bank:1QLY
RefSeq:NM_000061
RefSeq:NP_000052
UCSC human:Q06187
UniProt:Q06187
dbSNP Gene:695
Other identifiers related to this sequenceBTK_HUMAN, B2RAW1, Q32ML5, 4015752, U78027_rna4_at, CAB55876, 4NWM, CAB016689, U13429, 17112735, Q3MS96, U13423, 4015745, SM00219, X58957, L31572, 2Z0P, CCDS14482, IPR001245, PR00452, U13412, 2GE9, 1BTK, 4015713, 4015734, 8380905, 4015738, AAB60639, 695, PF00018, IPR001452, BC109079, 1K2P, 4015705, 4015741, 205504_at, BC109080, NM_000061, MIM:300755, 4015730, L31569, L31558, L31570, 4015731, IPR011009, A_23_P137139, U13425, 4015721, U13427, 1B55, BAG37008, Q9P0L4, AL035422, 1AWX, U10087, 3PJ3, L31567, AAI09080, 4015736, U10085, L31563, ENSG00000010671, 4015711, U13432, 3PIZ, IPR001849, SM00107, L31557, L31565, UPI0000126B16, PR00402, 3GEN, uc004ehg.2, PF00169, HGNC:1133, U10084, 4015751, IPR000980, PR00109, 4015733, U13414, 3PIX, ENST00000308731, IPR001562, AM051276, HPA002028, PF07714, AK314382, LRG_128, 3OCS, PF00779, SM00220, U13433, 3P08, A_33_P3277514, 3PJ1, U13430, OTTHUMP00000023676, 1BWN, CAJ19682, NP_000052, L31559, GE61511, EntrezGene:695, 3OCT, MIM:307200, Hs.159494, 1AWW, 4015718, PR00401, IPR000719, AAB64205, SM00326, 11730847_a_at, U13413, 4015714, 4015735, U13422, SM00252, PF00017, U13417, ILMN_1662026, 4015746, U13416, 8174051, L31561, 4015724, 4015720, 3PJ2, IPR002290, 4015716, 38213_at, L31564, 4015743, 4015729, 11756709_x_at, 4015732, 1QLY, 3PIY, PF07653, AAI09081, L31568, PH_hs_0009711, 4015710, 3K54, LRG_128t1, PF00069, AAC51347, U78027, U13424, AAF37340, U13410, U13415, L31571, IPR011511, U10086, BTK-006, AF153763, CAA41728, U13431, MIM:300300, AAA61479, U13428, L31566, ENSP00000308176, SM00233, g4557376_3p_at, HPA001198, IPR020635, BTK
Molecules with this sequenceBTK [cytosol] UKENBCdOOORHPGPPPPPPPURDDDDDDD
p-Y223,Y551-BTK [plasma membrane] UKENBCdOOORHPGPPPPPPPURDDDDDDD
p-Y223,Y551-BTK [cytosol] UKENBCdOOORHPGPPPPPPPURDDDDDDD
p-Y551-BTK [cytosol] UKENBCdOOORHPGPPPPPPPURDDDDDDD
Component ofactivated TLR2/4:p-4Y-MAL:PI(4,5)P2:BTK [plasma membrane]
MAL:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]
p-BTK:PIP3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane]
MyD88:MAL:BTK:activated TLR2/4 [plasma membrane]
oligo-MyD88:Mal:BTK:activated TLR [plasma membrane]
...
List all 26 items
Represented by generalisation(s)TEC,BTK,ITK,(TXK) [cytosol]
Src-kinases [cytosol]
p-SYK,p-BTK [cytosol]
p-2Y-TEC kinases [cytosol]
p-TEC kinases [cytosol]
SYK/BTK [cytosol]
Processes where molecules and complexes with this sequence are involved

Immune System

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 551
O4'-phospho-L-tyrosine at 223
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