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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:Q06187
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein kinase BTK ecNumber2.7.10.2/ecNumber alternativeName: Agammaglobulinemia tyrosine kinase shortName:ATK alternativeName: B-cell progenitor kinase shortName:BPK alternativeName: Bruton tyrosine kinase
Links to corresponding entries in other databasesBioGPS Gene:695
Brenda:2.7.10.2
CTD Gene:695
DOCK Blaster:1AWW
DOCK Blaster:1AWX
DOCK Blaster:1B55
DOCK Blaster:1BTK
DOCK Blaster:1BWN
DOCK Blaster:1K2P
DOCK Blaster:1QLY
EC:2.7.10.2
ENSEMBL:ENSG00000010671
GeneCards:Q06187
HapMap:NM_000061
IntEnz:2.7.10.2
KEGG Gene:695
NCBI Gene:695
OMIM:300300
OMIM:307200
Protein Data Bank:1AWW
Protein Data Bank:1AWX
Protein Data Bank:1B55
Protein Data Bank:1BTK
Protein Data Bank:1BWN
Protein Data Bank:1K2P
Protein Data Bank:1QLY
RefSeq:NM_000061
RefSeq:NP_000052
UCSC human:Q06187
UniProt:Q06187
dbSNP Gene:695
Other identifiers related to this sequenceBTK_HUMAN, B2RAW1, Q32ML5, ENSG00000010671, ENST00000308731, ENSP00000308176, 205504_at, 39191_at, 38213_at, U01922_at, U78027_rna4_at, g4557376_3p_at, A_23_P137139, CCDS14482, GE61511, AM051285, AJ888378, AM051278, AL035422, AJ888380, AM051283, AM051279, AF153763, AF153755, AM051276, AF153764, AF153762, AF153761, AF153758, AF153364, AF153756, AF153757, AF153759, AF153760, U78027, X58957, U10087, U10084, U10085, U10086, L31572, L31557, L31558, L31559, L31561, L31563, L31564, L31565, L31566, L31567, L31568, L31569, L31570, L31571, U13433, U13410, U13412, U13413, U13414, U13415, U13416, U13417, U13422, U13423, U13424, U13425, U13427, U13428, U13429, U13430, U13431, U13432, BC109079, BC109080, AJ888376, AM051280, AM051284, AM051277, EntrezGene:695, GI_4557376-S, ILMN_28021, IPI00029132, IPI00646149, IPI00844337, IPI00654849, IPI00746467, IPI00854612, MIM:300300, MIM:307200, OTTHUMP00000023677, OTTHUMT00000057532, OTTHUMT00000057533, 1AWW, 1AWX, 1B55, 1BTK, 1BWN, 1K2P, 1QLY, CAJ19691, CAI59837, CAJ19684, CAI59839, CAJ19689, CAJ19685, AAF37340, AAF37332, CAJ19682, AAF37341, AAF37339, AAF37338, AAF37335, AAF61477, AAF37333, AAF37334, AAF37336, AAF37337, CAA41728, AAB60639, AAA61479, AAC51347, AAB64205, CAB55876, AAI09080, AAI09081, CAI42359, CAI59842, CAJ19686, CAJ19690, CAJ19683, NM_000061, NP_000052, Hs.159494, Q3MS87, Q572P3, Q3MS94, Q572P1, Q3MS89, Q3MS93, Q9P0L4, Q9P0L8, Q3MS96, Q9P0L3, Q9P0L5, Q9P0L6, Q9P0L7, Q9P0M0, Q9NPI2, Q9NPI3, Q06187, Q5JY90, Q572P5, Q3MS92, Q3MS88, Q3MS95, Q3MS87_HUMAN, Q572P3_HUMAN, Q3MS94_HUMAN, Q572P1_HUMAN, Q3MS89_HUMAN, Q3MS93_HUMAN, Q9P0L4_HUMAN, Q9P0L8_HUMAN, Q3MS96_HUMAN, Q9P0L3_HUMAN, Q9P0L5_HUMAN, Q9P0L6_HUMAN, Q9P0L7_HUMAN, Q9P0M0_HUMAN, Q9NPI2_HUMAN, Q9NPI3_HUMAN, BTK_HUMAN, Q5JY90_HUMAN, Q572P5_HUMAN, Q3MS92_HUMAN, Q3MS88_HUMAN, Q3MS95_HUMAN, IPR000719, IPR008266, IPR000980, IPR001245, IPR001452, IPR001562, IPR013315, IPR001849, IPR011511
Molecules with this sequenceBTK [cytosol] UKENBCdOORHGURPPPPPPPDDDDDDD
p-Y223,Y551-BTK [plasma membrane] UKENBCdOORHGURPPPPPPPDDDDDDD
p-Y223,Y551-BTK [cytosol] UKENBCdOORHGURPPPPPPPDDDDDDD
p-Y551-BTK [cytosol] UKENBCdOORHGURPPPPPPPDDDDDDD
Component ofactivated TLR2/4:p-4Y-MAL:PI(4,5)P2:BTK [plasma membrane]
MAL:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane]
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]
p-BTK:PIP3 [plasma membrane]
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane]
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane]
MyD88:MAL:BTK:activated TLR2/4 [plasma membrane]
oligo-MyD88:Mal:BTK:activated TLR [plasma membrane]
...
List all 26 items
Represented by generalisation(s)TEC,BTK,ITK,(TXK) [cytosol]
Src-kinases [cytosol]
p-SYK,p-BTK [cytosol]
p-2Y-TEC kinases [cytosol]
p-TEC kinases [cytosol]
SYK/BTK [cytosol]
Processes where molecules and complexes with this sequence are involved

Immune System

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 551
O4'-phospho-L-tyrosine at 223
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