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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P00533
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Epidermal growth factor receptor ecNumber2.7.10.1/ecNumber alternativeName: Proto-oncogene c-ErbB-1 alternativeName: Receptor tyrosine-protein kinase erbB-1
Links to corresponding entries in other databasesBioGPS Gene:1956
Brenda:2.7.10.1
CTD Gene:1956
DOCK Blaster:1DNQ
DOCK Blaster:1DNR
DOCK Blaster:1IVO
DOCK Blaster:1M14
DOCK Blaster:1M17
DOCK Blaster:1MOX
DOCK Blaster:1NQL
DOCK Blaster:1XKK
DOCK Blaster:1Z9I
DOCK Blaster:2EXP
DOCK Blaster:2GS2
DOCK Blaster:2GS7
EC:2.7.10.1
ENSEMBL:ENSG00000146648
GeneCards:P00533
HapMap:NM_005228
HapMap:NM_201283
IntEnz:2.7.10.1
KEGG Gene:1956
NCBI Gene:1956
OMIM:131550
OMIM:211980
Protein Data Bank:1DNQ
Protein Data Bank:1DNR
Protein Data Bank:1IVO
Protein Data Bank:1M14
Protein Data Bank:1M17
Protein Data Bank:1MOX
Protein Data Bank:1NQL
Protein Data Bank:1XKK
Protein Data Bank:1Z9I
Protein Data Bank:2EXP
Protein Data Bank:2GS2
Protein Data Bank:2GS7
RefSeq:NM_005228
RefSeq:NM_201283
RefSeq:NP_005219
RefSeq:NP_958440
UCSC human:P00533
UniProt:P00533
dbSNP Gene:1956
Other identifiers related to this sequenceEGFR_HUMAN, O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5, ENSG00000146648, ENST00000275493, ENSP00000275493, 1537_at, 211607_x_at, 201983_s_at, 210984_x_at, 201984_s_at, 211550_at, 1565484_x_at, 1565483_at, 37327_at, 48285_at, X00588_at, g1628549_3p_s_at, Hs.77432.0.S1_3p_a_at, g4885198_3p_a_at, g12002211_3p_at, Hs2.367845.1.S1_3p_x_at, Hs2.367845.1.S1_3p_at, A_14_P106592, A_23_P215790, A_23_P215798, A_32_P24249, A_32_P37912, CCDS5514, CCDS5515, CCDS5516, GE59632, AB221348, AY698024, AY698023, AF125539, AF125538, BC128419, BC118665, DQ220295, U48723, AB209442, AC073324, AY550966, X00588, U95089, U48722, U48724, U48725, U48726, U48727, U48728, U48729, AF288738, AY588246, AF277897, AF125253, X06370, X00663, M38425, M11234, EntrezGene:1956, GI_41327737-I, GI_41327735-I, ILMN_2682, ILMN_15615, ILMN_15848, IPI00018274, IPI00221346, IPI00221347, IPI00221348, MIM:131550, MIM:211980, 1DNQ, 1DNR, 1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1Z9I, 2EXP, 2GS2, 2GS7, BAE15958, AAT97979, AAT97978, AAI28420, AAI18666, ABB36657, AAC50803, BAD92679, AAS07524, AAT52212, CAA25240, AAB53063, AAC50802, AAC50804, AAC50796, AAC50797, AAC50798, AAC50799, AAC50800, AAC50801, AAG35786, AAG35787, AAG35788, AAG35789, AAG35790, AAS83109, AAK01080, AAG43240, AAG43243, CAA29668, CAA25282, AAA63171, AAA52370, AAG43244, NM_005228, NM_201283, NM_201284, NM_201282, NP_958440, NP_005219, NP_958441, NP_958439, OTTHUMT00000059982, OTTHUMT00000251456, OTTHUMT00000251457, OTTHUMT00000251458, Hs.488293, Hs.609934, Q4H1F3, Q68GS5, Q68GS6, A2VCQ7, Q147T7, Q30BI0, Q8WZA5, Q59FL8, Q75MF2, Q2TTR7, P00533, Q9H3C8, Q4H1F3_HUMAN, Q68GS5_HUMAN, Q68GS6_HUMAN, A2VCQ7_HUMAN, Q147T7_HUMAN, Q30BI0_HUMAN, Q8WZA5_HUMAN, Q59FL8_HUMAN, Q75MF2_HUMAN, Q2TTR7_HUMAN, EGFR_HUMAN, Q9H3C8_HUMAN, P00533-2, P00533-3, P00533-4, IPR000719, IPR008266, IPR001245, IPR000494, IPR006211
Molecules with this sequencep-6Y-EGFR [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-Y1086,Y1101-EGFR [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-4Y-EGFR [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR G719S [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR G719S [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L858R [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L858R [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR G719A [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR G719C [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR G719C [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR G719A [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L861Q [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L861Q [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR E746_A750del [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR E746_A750del [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L858R;T790M [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR E746_A750del;T790M [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L858R;T790M [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR E746_A750del;T790M [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFRvIII [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L747_P753delinsS [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L747_T751delinsP [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L747_T751del [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L747_S752del [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR E746_S752delinsV [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR E746_T751delinsA [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR L747_A750delinsP [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR E746_T751delinsA [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L747_P753delinsS [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR E746_S752delinsV [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L747_S752del [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L747_T751del [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L747_T751delinsP [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR L747_A750delinsP [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-5Y-EGFRvIII [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR A289T [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR G598V [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR T263P [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR D770_N771insNPH [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR A289V [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR D770_N771insNPG [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR V738_K739insKIPVAI [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR M766_A767insASV [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR A289D [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
EGFR R108K [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR A289V [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR D770_N771insNPG [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR T263P [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR R108K [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR G598V [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR A289D [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR A289T [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR D770_N771insNPH [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR M766_A767insASV [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] UKENBCdOORRHHGURRPPPPPPPPPPPPDDDDDDDDDDDD
Component ofEGF:Phospho-EGFR [plasma membrane]
EGF:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
EGF:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15R:Eps15 [plasma membrane]
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15R:Eps15 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:Eps15R:Eps15:Clathrin [plasma membrane]
EGF:p-6Y-EGFR:CBL:CIN85 [plasma membrane]
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane]
...
List all 92 items
Represented by generalisation(s)Phosphorylated EGFR dimer [plasma membrane]
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane]
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]
Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane]
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane]
Ligand-responsive EGFR mutants [plasma membrane]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

Plcg1 binds P-ERBB2:P-EGFR [Homo sapiens]

Developmental Biology

Shc1 binds phosphorylated ERBB2:EGFR heterodimers [Homo sapiens]

Plcg1 phosphorylation by P-ERBB2:P-EGFR [Homo sapiens]

Disease

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 1068
O4'-phospho-L-tyrosine at 1101
O4'-phospho-L-tyrosine at 1086
O4'-phospho-L-tyrosine at 1148
O4'-phospho-L-tyrosine at 1173
O4'-phospho-L-tyrosine at 992
O4'-phospho-L-tyrosine at 1045
glycine 719 replaced with L-serine
L-leucine 858 replaced with L-arginine
glycine 719 replaced with L-alanine
glycine 719 replaced with L-cysteine
L-leucine 861 replaced with L-glutamine
L-alanine removal at 750
L-glutamic acid removal at 749
L-glutamic acid removal at 746
L-arginine removal at 748
L-leucine removal at 747
L-threonine 790 replaced with L-methionine
L-proline 753 replaced with L-serine
L-threonine removal at 751
L-serine removal at 752
L-threonine 751 replaced with L-proline
L-serine 752 replaced with L-valine
L-threonine 751 replaced with L-alanine
L-alanine 750 replaced with L-proline
Deletion of residues 30 to 296
Insertion of residues 739 to 744 at 739 from UniProt:P00533 EGFR
glycine 598 replaced with L-valine
L-threonine 263 replaced with L-proline
L-histidine 773 replaced with glycine
Insertion of residues 767 to 769 at 767 from UniProt:P00533 EGFR
Insertion of residues 771 to 773 at 774 from UniProt:P00533 EGFR
L-alanine 289 replaced with L-threonine
L-alanine 289 replaced with L-aspartic acid
L-arginine 108 replaced with L-lysine
L-alanine 289 replaced with L-valine
Insertion of residues 771 to 773 at 771 from UniProt:P00533 EGFR
L-arginine 297 replaced with glycine
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