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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P00533
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Epidermal growth factor receptor ecNumber2.7.10.1/ecNumber alternativeName: Proto-oncogene c-ErbB-1 alternativeName: Receptor tyrosine-protein kinase erbB-1
Links to corresponding entries in other databasesBioGPS Gene:1956
Brenda:2.7.10.1
CTD Gene:1956
DOCK Blaster:1DNQ
DOCK Blaster:1DNR
DOCK Blaster:1IVO
DOCK Blaster:1M14
DOCK Blaster:1M17
DOCK Blaster:1MOX
DOCK Blaster:1NQL
DOCK Blaster:1XKK
DOCK Blaster:1Z9I
DOCK Blaster:2EXP
DOCK Blaster:2GS2
DOCK Blaster:2GS7
EC:2.7.10.1
ENSEMBL:ENSG00000146648
GeneCards:P00533
HapMap:NM_005228
HapMap:NM_201283
IntEnz:2.7.10.1
KEGG Gene:1956
NCBI Gene:1956
OMIM:131550
OMIM:211980
Orphanet:15917
PRO:P00533
Protein Data Bank:1DNQ
Protein Data Bank:1DNR
Protein Data Bank:1IVO
Protein Data Bank:1M14
Protein Data Bank:1M17
Protein Data Bank:1MOX
Protein Data Bank:1NQL
Protein Data Bank:1XKK
Protein Data Bank:1Z9I
Protein Data Bank:2EXP
Protein Data Bank:2GS2
Protein Data Bank:2GS7
RefSeq:NM_005228
RefSeq:NM_201283
RefSeq:NP_005219
RefSeq:NP_958440
UCSC human:P00533
UniProt:P00533
ZINC_target:P00533
dbSNP Gene:1956
Other identifiers related to this sequenceEGFR_HUMAN, O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5, 2ITY, 3002761, EntrezGene:1956, U48722, AAG35787, AF277897, 3W2O, 1M14, 4JRV, 2KS1, 11742247_a_at, 2EB3, 4JR3, 3002729, 3UG2, HQ999997, 3G5Y, 3002731, Hs.488293, 4I20, AAC50799, 3002641, U48724, PF01030, AF125538, uc003tqi.3, CAB000035, AAC50801, 2RF9, 1565484_x_at, M11234, 3POZ, 2ITW, 4I23, 3G5V, ENSG00000146648, 3C09, 3002749, 1IVO, 2EXP, 2RFE, NM_201282, 2J5F, 2ITO, 4KRO, 3002763, IPR006211, AAG43240, AAA52370, ENSP00000342376, 0000840253, X00588, 3NJP, 1565483_at, 1DNR, AAG35789, U48728, AAC50797, X00663, 2RGP, 3OP0, 4G5J, 211607_x_at, PH_hs_0044733, 3LZB, 3002757, CAA29668, 3W32, OTTHUMP00000159663, AAC50804, 4JQ7, Hs2.367845.1.S1_3p_x_at, 2J6M, AC006977, 3002767, 1956, 2GS7, 2JIU, AF125539, 3QWQ, AAT97979, 2GS2, 3W2R, 3002747, 4I1Z, U48727, 3002743, AY698024, IPR006212, 1M17, AC073324, 1XKK, PF00757, 4I21, F1JTL6, 4KRP, ILMN_1755535, Hs.731652, 4G5P, Hs.605083, AAB53063, M38425, MIM:131550, 2ITN, EGFR-003, IPR009030, 1YY9, 1Z9I, 3OB2, 4I22, 3002733, 3UG1, AAC50796, 2ITP, Hs.609934, HPA001200, 4LL0, 4I24, 3IKA, AY588246, 3002738, 2M0B, 3VJN, U48723, 3VRP, CAA25240, 2ITZ, 11733760_a_at, 3B2V, 2JIT, 2M20, 3BUO, UPI000002A8CB, AAC50802, IPR000494, 4LRM, 2RFD, AAA63171, AF288738, Hs2.367845.1.S1_3p_at, 3002753, 3002760, 4KRL, 3GT8, 2GS6, SM00261, 3W2S, 2ITV, 2ITX, 210984_x_at, ADY76965, HGNC:3236, AF125253, 2EXQ, 3VRR, 4HJO, EGFR, U48725, U95089, 1NQL, NP_958439, A_33_P3351955, U48729, 2ITU, 3002741, 3002642, 1MOX, 2J5E, 4LI5, 3VJO, AAS83109, 4LQM, 3P0Y, 1DNQ, AAG35790, AAG43243, 4JQ8, AAG35786, 3PFV, 3002750, CCDS5516, AAC50800, Hs.708569, 1505215, 3W2P, 2EB2, AAG35788, CAA25282, AAK01080, 3BEL, U48726, 2JIV, AAC50798, HPA018530, C9JYS6, 4KRM, MIM:211980, 2ITT, 3B2U, 2ITQ, NM_005228, 3W33, X06370, g1628549_3p_s_at, 3W2Q, EGFR-002, ENSP00000345973, g12002211_3p_at, 17046135, 3002769, 211550_at, 3002770, CCDS5515, AAG43244, 11738815_at, GE85333, 0005900148, 3002771, uc003tqj.3, NM_201284, NP_958441, UPI000002A8CA, Q9H3C8, OTTHUMP00000159662, ILMN_1728858, uc003tqh.3, UPI000002A8C9, NP_958440, 3002751, OTTHUMP00000209211, NM_201283, ENSP00000413843, EGFR-005, Q8WZA5, 0002940025, A_33_P3351944, CCDS47587, AAC50803, BAF80003, Q75MF2, 3002818, Hs.77432.0.S1_3p_a_at, PH_hs_0004462, AFK93474, A_23_P215790, 3002786, JQ739166, AFK93471, CCDS5514, AFK93475, 3002807, BAL41217, IPR011009, I3WA73, 3002798, 65700_at, 3002801, 3002800, 0006350504, JQ739167, g4885198_3p_a_at, PF07714, 3002808, SM00220, AB686642, 11725103_s_at, uc003tqk.3, 11751983_a_at, 11725104_a_at, ENSP00000275493, Hs.279898.0.S1_3p_at, ILMN_1798975, I3WA72, 3002816, GE59632, AB360855, 3002778, AFK93476, PF00069, 3002812, 3002802, G9MC81, JQ739163, 201984_s_at, 3002822, SM00219, EGFR-001, 3002815, 3002814, 3002775, AFK93477, 3002819, IPR001245, IPR016245, X00588_at, JQ739160, 11725102_at, 8132860, OTTHUMP00000159661, 3002820, 3002823, 224999_at, AFK93473, UPI000003E750, 3002779, 1537_at, E9PFD7, JQ739164, PR00109, 3002811, 3002813, 201983_s_at, NP_005219, IPR000719, JQ739162, JQ739165, ILMN_1905285, AFK93478, 3002817, 3002824, 3002776, IPR002290, 37327_at, 48285_at, AAS07524, A7VN06, 3002806, 3002821, A_14_P106592, 3002825, IPR020635
Molecules with this sequencep-6Y-EGFR [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-Y1086,Y1101-EGFR [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-4Y-EGFR [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR G719S [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR G719S [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L858R [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L858R [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR G719A [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR G719C [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR G719C [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR G719A [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L861Q [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L861Q [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR E746_A750del [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR E746_A750del [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L858R;T790M [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR E746_A750del;T790M [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L858R;T790M [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR E746_A750del;T790M [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFRvIII [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L747_P753delinsS [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L747_T751delinsP [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L747_T751del [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L747_S752del [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR E746_S752delinsV [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR E746_T751delinsA [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR L747_A750delinsP [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR E746_T751delinsA [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L747_P753delinsS [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR E746_S752delinsV [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L747_S752del [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L747_T751del [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L747_T751delinsP [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR L747_A750delinsP [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-5Y-EGFRvIII [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR A289T [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR G598V [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR T263P [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR D770_N771insNPH [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR A289V [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR D770_N771insNPG [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR V738_K739insKIPVAI [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR M766_A767insASV [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR A289D [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
EGFR R108K [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR A289V [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR D770_N771insNPG [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR T263P [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR R108K [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR G598V [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR A289D [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR A289T [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR D770_N771insNPH [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR M766_A767insASV [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] UKENBCdOOORRHHPGPPPPPPPPPPPPURRDDDDDDDDDDDDZ
Component ofEGF:Phospho-EGFR [plasma membrane]
EGF:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
EGF:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15R:Eps15 [plasma membrane]
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15R:Eps15 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:Eps15R:Eps15:Clathrin [plasma membrane]
EGF:p-6Y-EGFR:CBL:CIN85 [plasma membrane]
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane]
...
List all 92 items
Represented by generalisation(s)Phosphorylated EGFR dimer [plasma membrane]
Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane]
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]
Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane]
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane]
Ligand-responsive EGFR mutants [plasma membrane]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

Plcg1 binds P-ERBB2:P-EGFR [Homo sapiens]

Developmental Biology

Shc1 binds phosphorylated ERBB2:EGFR heterodimers [Homo sapiens]

Plcg1 phosphorylation by P-ERBB2:P-EGFR [Homo sapiens]

Disease

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 1068
O4'-phospho-L-tyrosine at 1101
O4'-phospho-L-tyrosine at 1086
O4'-phospho-L-tyrosine at 1148
O4'-phospho-L-tyrosine at 1173
O4'-phospho-L-tyrosine at 992
O4'-phospho-L-tyrosine at 1045
glycine 719 replaced with L-serine
L-leucine 858 replaced with L-arginine
glycine 719 replaced with L-alanine
glycine 719 replaced with L-cysteine
L-leucine 861 replaced with L-glutamine
L-alanine removal at 750
L-glutamic acid removal at 749
L-glutamic acid removal at 746
L-arginine removal at 748
L-leucine removal at 747
L-threonine 790 replaced with L-methionine
L-proline 753 replaced with L-serine
L-threonine removal at 751
L-serine removal at 752
L-threonine 751 replaced with L-proline
L-serine 752 replaced with L-valine
L-threonine 751 replaced with L-alanine
L-alanine 750 replaced with L-proline
Deletion of residues 30 to 296
Insertion of residues 739 to 744 at 739 from UniProt:P00533 EGFR
glycine 598 replaced with L-valine
L-threonine 263 replaced with L-proline
L-histidine 773 replaced with glycine
Insertion of residues 767 to 769 at 767 from UniProt:P00533 EGFR
Insertion of residues 771 to 773 at 774 from UniProt:P00533 EGFR
L-alanine 289 replaced with L-threonine
L-alanine 289 replaced with L-aspartic acid
L-arginine 108 replaced with L-lysine
L-alanine 289 replaced with L-valine
Insertion of residues 771 to 773 at 771 from UniProt:P00533 EGFR
L-arginine 297 replaced with glycine
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