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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P08246
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Neutrophil elastase ecNumber3.4.21.37/ecNumber alternativeName: Bone marrow serine protease alternativeName: Elastase-2 alternativeName: Human leukocyte elastase shortName:HLE alternativeName: Medullasin alternativeName: PMN elastase
Links to corresponding entries in other databasesBioGPS Gene:1991
Brenda:3.4.21.37
CTD Gene:1991
DOCK Blaster:1B0F
DOCK Blaster:1H1B
DOCK Blaster:1HNE
DOCK Blaster:1PPF
DOCK Blaster:1PPG
EC:3.4.21.37
ENSEMBL:ENSG00000197561
GeneCards:P08246
HapMap:NM_001972
IntEnz:3.4.21.37
KEGG Gene:1991
NCBI Gene:1991
OMIM:130130
OMIM:162800
Protein Data Bank:1B0F
Protein Data Bank:1H1B
Protein Data Bank:1HNE
Protein Data Bank:1PPF
Protein Data Bank:1PPG
RefSeq:NM_001972
RefSeq:NP_001963
UCSC human:P08246
UniProt:P08246
dbSNP Gene:1991
Other identifiers related to this sequenceELNE_HUMAN, P09649, Q6B0D9, Q6LDP5, ENSG00000197561, ENST00000263621, ENSP00000263621, 206871_at, 37096_at, M20203_s_at, Y00477_at, M27783_s_at, g4503548_3p_at, A_14_P112290, A_23_P130961, A_32_P885145, CCDS12045, Y00477, M20203, M20199, M20200, M20201, M34379, AY596461, BC074816, BC074817, D00187, X05875, J03545, M27783, EntrezGene:1991, GI_4503548-S, ILMN_24461, IPI00027769, MIM:130130, MIM:162800, 1B0F, 1H1B, 1HNE, 1PPF, 1PPG, CAA68537, AAA36359, AAA36173, AAS89303, AAH74816, AAH74817, BAA00128, CAA29299, CAA29300, AAA52378, AAA35792, NM_001972, NP_001963, Hs.99863, P08246, ELNE_HUMAN, IPR001254, IPR001314
Molecules with this sequenceELANE [extracellular region] UKENBCdOORHGURPPPPPDDDDD
Represented by generalisation(s)proMMP1 initial activators [extracellular region]
proMMP8 initial activators [extracellular region]
Elastin-degrading extracellular proteinases [extracellular region]
MMP1, MMP9, MMP12, ELANE [extracellular region]
MMP7 initial activators [extracellular region]
Processes where molecules and complexes with this sequence are involved

Degradation of fibrilin-1 by Elane [Bos taurus]

Nid1 degradation by MMP1, 9, 12, ELANE [Homo sapiens]

Extracellular matrix organization

Cleavage of collagen type VIII by ELANE [Homo sapiens]

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