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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P08246
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Neutrophil elastase ecNumber3.4.21.37/ecNumber alternativeName: Bone marrow serine protease alternativeName: Elastase-2 alternativeName: Human leukocyte elastase shortName:HLE alternativeName: Medullasin alternativeName: PMN elastase
Links to corresponding entries in other databasesBioGPS Gene:1991
Brenda:3.4.21.37
CTD Gene:1991
DOCK Blaster:1B0F
DOCK Blaster:1H1B
DOCK Blaster:1HNE
DOCK Blaster:1PPF
DOCK Blaster:1PPG
EC:3.4.21.37
ENSEMBL:ENSG00000197561
GeneCards:P08246
HapMap:NM_001972
IntEnz:3.4.21.37
KEGG Gene:1991
NCBI Gene:1991
OMIM:130130
OMIM:162800
Orphanet:15969
PRO:P08246
Protein Data Bank:1B0F
Protein Data Bank:1H1B
Protein Data Bank:1HNE
Protein Data Bank:1PPF
Protein Data Bank:1PPG
RefSeq:NM_001972
RefSeq:NP_001963
UCSC human:P08246
UniProt:P08246
dbSNP Gene:1991
Other identifiers related to this sequenceELNE_HUMAN, P09649, Q6B0D9, Q6LDP5, BAA00128, IPR001314, M34379, ELA2, XM_006725397, 3815237, 3815234, B2MUD5, 3Q77, X05875, MIM:130130, AAA36173, AAS89303, ILMN_1706635, M27783_s_at, 3815235, PH_hs_0005576, 1H1B, AAA52378, ENSP00000466090, M20200, 1B0F, AAH74816, ELANE, 1PPG, 0002680403, M20203_s_at, LRG_57, J03545, 1HNE, BC074817, 3815236, IPR001254, 2Z7F, CAA29300, XP_006725460, AAH74817, PR00722, AAA35792, 3815240, CAA29299, 2902087, A_14_P112290, 206871_at, CCDS12045, EntrezGene:1991, SM00020, Y00477, 1PPF, NM_001972, BC074816, 11727965_at, OTTHUMP00000267630, HGNC:3309, D00187, Hs.99863, uc002lqb.3, CAB015409, M20203, AAA36359, ELANE-001, AY596461, PF09342, CAA68537, ENSG00000197561, g4503548_3p_at, EU617980, UPI0000129E6B, 3Q76, 16856292, 3815238, PF00089, 3815241, A_23_P130961, IPR015420, M20199, M20201, Y00477_at, M27783, 1991, XP_005259574, 2RG3, 3815242, ACC78413, MIM:202700, MIM:162800, 8024056, IPR009003, 3815239, 37096_at, XM_005259517, ENSP00000263621, ENST00000263621, LRG_57t1, NP_001963, ELANE-201
Molecules with this sequenceELANE [extracellular region] UKENBCdOOORHPGPPPPPURDDDDD
Represented by generalisation(s)proMMP1 initial activators [extracellular region]
proMMP8 initial activators [extracellular region]
Elastin-degrading extracellular proteinases [extracellular region]
MMP1, MMP9, MMP12, ELANE [extracellular region]
MMP7 initial activators [extracellular region]
Processes where molecules and complexes with this sequence are involved

Degradation of fibrilin-1 by Elane [Bos taurus]

Nid1 degradation by MMP1, 9, 12, ELANE [Homo sapiens]

Extracellular matrix organization

Cleavage of collagen type VIII by ELANE [Homo sapiens]

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