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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:O75874
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Isocitrate dehydrogenase [NADP] cytoplasmic shortName:IDH ecNumber1.1.1.42/ecNumber alternativeName: Cytosolic NADP-isocitrate dehydrogenase alternativeName: IDP alternativeName: NADP(+)-specific ICDH alternativeName: Oxalosuccinate decarboxylase
Links to corresponding entries in other databasesBioGPS Gene:3417
Brenda:1.1.1.42
CTD Gene:3417
DOCK Blaster:1T09
DOCK Blaster:1T0L
EC:1.1.1.42
ENSEMBL:ENSG00000138413
GeneCards:O75874
HapMap:NM_005896
IntEnz:1.1.1.42
KEGG Gene:3417
NCBI Gene:3417
OMIM:147700
Orphanet:21083
PRO:O75874
Protein Data Bank:1T09
Protein Data Bank:1T0L
RefSeq:NM_005896
RefSeq:NP_005887
UCSC human:O75874
UniProt:O75874
dbSNP Gene:3417
Other identifiers related to this sequenceIDHC_HUMAN, Q567U4, Q6FHQ6, Q7Z3V0, Q93090, Q9NTJ9, Q9UKW8, 11746174_s_at, 2940678, 16907758, IPR004790, Q0QER2, Hs2.11223.2.S1_3p_s_at, AC016697, 64372_r_at, V9HWJ2, 8058552, AAH93020, 2597032, UPI000012D1B4, 2597019, 1T09, NM_005896, BAG63486, 39023_at, BX537411, 3MAR, AAD29284, Hs.593422, 201193_at, 4KZO, PF00180, ENSP00000260985, AAX93221, 2597015, AL136702, 4I3L, 3417, IDH1-001, 2597029, IDH1, HGNC:5382, AF113917, 3INM, 11718474_a_at, ILMN_1696432, DQ403082, CAB033218, AF020038, CH471063, 11718475_s_at, 3MAP, EU794623, 4L03, 0001340671, ILMN_2091347, 2597021, 2597040, ACJ13677, g5174470_3p_x_at, AK302105, U62389, B4DXS4, NP_005887, LRG_610, BC093020, C9JJE5, 4L06, ABD77215, 4I3K, 3MAS, 2597034, U62389_at, 1555037_a_at, g5174470_3p_at, 2597016, CR541695, CAB66637, AAH12846, HPA035248, 2597023, CAD97653, 2597041, BC012846, EAW70439, CCDS2381, 2940682, 2597013, OTTHUMP00000163870, MIM:147700, C9JLU6, EntrezGene:3417, HEL-S-26, GE54157, PH_hs_0043200, AAB17375, C9J4N6, MIM:137800, uc002vcu.4, 1T0L, CAB062556, PH_hs_0030991, CAG46496, 2597014, HPA057936, AAD02918, ENSG00000138413, IPR024084, 4L04, 2597037, NM_001282386, ENSP00000410513, OTTHUMP00000206464, NP_001269315, ENST00000446179, uc002vct.4, IDH1-004, LRG_610t3, 2597036, NM_001282387, IDH1-006, ENST00000415913, NP_001269316, 2597038, OTTHUMP00000206466, uc002vcs.4, ENSP00000390265, LRG_610t2
Molecules with this sequenceIDH1 [peroxisomal matrix] UKENBCdOORHPGPPURDD
IDH1 [cytosol] UKENBCdOORHPGPPURDD
IDH1 R132L mutant [cytosol] UKENBCdOORHPGPPURDD
IDH1 R132H mutant [cytosol] UKENBCdOORHPGPPURDD
IDH1 R132C mutant [cytosol] UKENBCdOORHPGPPURDD
IDH1 R132S mutant [cytosol] UKENBCdOORHPGPPURDD
Component ofIDH1 dimer [cytosol]
IDH1 dimer [peroxisomal matrix]
IDH1 R132C dimer [cytosol]
IDH1 R132H dimer [cytosol]
IDH1 R132L dimer [cytosol]
IDH1 R132S dimer [cytosol]
Processes where molecules and complexes with this sequence are involved

Metabolism

Disease

Modifications in molecules with this sequenceL-arginine 132 replaced with L-serine
L-arginine 132 replaced with L-leucine
L-arginine 132 replaced with L-histidine
L-arginine 132 replaced with L-cysteine
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