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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:O15111
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Inhibitor of nuclear factor kappa-B kinase subunit alpha shortName:I-kappa-B kinase alpha shortName:IKK-A shortName:IKK-alpha shortName:IkBKA shortName:IkappaB kinase ecNumber2.7.11.10/ecNumber alternativeName: Conserved helix-loop-helix ubiquitous kinase alternativeName: I-kappa-B kinase 1 shortName:IKK1 alternativeName: Nuclear factor NF-kappa-B inhibitor kinase alpha shortName:NFKBIKA alternativeName: Transcription factor 16 shortName:TCF-16
Links to corresponding entries in other databasesBioGPS Gene:1147
Brenda:2.7.11.10
CTD Gene:1147
EC:2.7.11.10
ENSEMBL:ENSG00000213341
GeneCards:O15111
HapMap:NM_001278
IntEnz:2.7.11.10
KEGG Gene:1147
NCBI Gene:1147
OMIM:600664
PRO:O15111
RefSeq:NM_001278
RefSeq:NP_001269
UCSC human:O15111
UniProt:O15111
ZINC_target:O15111
dbSNP Gene:1147
Other identifiers related to this sequenceIKKA_HUMAN, O14666, Q13132, Q5W0I4, Q92467, 3303327, PF07714, 3303333, 209666_s_at, SM00219, 1147, 16902410, IPR029071, SM00220, CCDS7488, 3303337, UPI000013D6C7, CAB004240, 3303310, IPR001245, PH_hs_0011697, 3303338, CHUK, AF009225, 33770_at, AAD08996, 7935707, NP_001269, AF012890, 3BRT, 3303298, MIM:600664, CHUK-001, A_23_P46748, 3303314, ILMN_1677041, 3303322, 3303304, IPR000719, NM_001278, 11754797_a_at, 3303326, IPR022007, CAH72401, Hs.594380, AAC50713, HGNC:1974, AY652653, U22512, 3303336, 3303331, AAT49098, GE81000, IPR002290, 3303309, 3303330, 3303301, IPR011009, AAC51662, A_33_P3258141, GE62511, AAC51671, 3303320, PF12179, ENSP00000359424, 3303312, 3303299, AL138921, AF080157, 7558004, 0006110142, 3303321, ENSG00000213341, MIM:613630, g4185272_3p_s_at, 3303332, PF00069, 16717469, 3303328, EntrezGene:1147, 3303335, HPA001402, 3303329, 3303324, uc001kqp.3, 3303334, CAB018564, 3303315, 3303325, OTTHUMP00000020273, PR00109, IPR020635, 3303302
Molecules with this sequenceIKKA [cytosol] UKENBCdORHPGURZ
p-S176,S180-IKKA [cytosol] UKENBCdORHPGURZ
p-T23-CHUK [cytosol] UKENBCdORHPGURZ
CHUK [plasma membrane] UKENBCdORHPGURZ
Component ofIKKA:IKKB:NEMO [cytosol]
p-S177,S181-IKKB:IKKA:NEMO [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol]
Active IKK complex [cytosol]
Activated IKK Complex [cytosol]
IKKA:IKKB:NEMO [plasma membrane]
Poly-K6-Ub-hp-IRAK1:IKK complex [plasma membrane]
dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane]
activated TLR4/TLR3:TRIF:K63-pUb-RIP1:IKKcomplex [endosome membrane]
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol]
...
List all 12 items
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Immune System

Disease

TRAF6 Mediated Induction of proinflammatory cytokines

Modifications in molecules with this sequenceO-phospho-L-serine at 176
O-phospho-L-threonine at 23
O-phospho-L-serine at 180
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