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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P06213
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Insulin receptor shortName:IR ecNumber2.7.10.1/ecNumber cdAntigenNameCD220/cdAntigenName component recommendedName: Insulin receptor subunit alpha /component component recommendedName: Insulin receptor subunit beta /component
Links to corresponding entries in other databasesBioGPS Gene:3643
Brenda:2.7.10.1
CTD Gene:3643
DOCK Blaster:1GAG
DOCK Blaster:1I44
DOCK Blaster:1IR3
DOCK Blaster:1IRK
DOCK Blaster:1P14
DOCK Blaster:1RQQ
DOCK Blaster:2AUH
DOCK Blaster:2B4S
EC:2.7.10.1
ENSEMBL:ENSG00000171105
GeneCards:P06213
HapMap:NM_000208
IntEnz:2.7.10.1
KEGG Gene:3643
NCBI Gene:3643
OMIM:125853
OMIM:147670
OMIM:246200
OMIM:262190
OMIM:609968
OMIM:610549
Orphanet:16263
PRO:P06213
Protein Data Bank:1GAG
Protein Data Bank:1I44
Protein Data Bank:1IR3
Protein Data Bank:1IRK
Protein Data Bank:1P14
Protein Data Bank:1RQQ
Protein Data Bank:2AUH
Protein Data Bank:2B4S
RefSeq:NM_000208
RefSeq:NP_000199
UCSC human:P06213
UniProt:P06213
dbSNP Gene:3643
Other identifiers related to this sequenceINSR_HUMAN, Q17RW0, Q59H98, Q9UCB7, Q9UCB8, Q9UCB9, ABC46553, DQ333194, SM00219, M32833, 3848251, ENSP00000342838, M29929, 2Z8C, M32838, 3BU5, A_33_P3335725, DQ333196, IPR001245, 3BU3, 2MFR, ABP68905, AAA86791, AAA59177, DQ333192, 3848341, Q2PJC5, PF01030, EF207604, DQ021481, PH_hs_0049088, 3W12, Hs.694195, 16867915, Q2PJC4, 2DTG, ABC46550, 3848297, M32831, M32829, 213792_s_at, MIM:610549, 1IR3, M32836, 3LOH, IPR006211, 1GAG, PH_hs_0025683, MIM:246200, INSR, 3848304, 3848260, Q4U0V1, 2983222, 2HR7, ABC46548, IPR011009, AC125387, ILMN_1670918, A4ZPI8, 3848282, 3848253, 3EKN, M32839, 3848266, B4DTR7, 207851_s_at, Q2PJC1, M32842, 2B4S, uc002mge.1, M23100, M32827, 1I44, 11720857_a_at, 1572_s_at, 3EKK, 3848263, M32832, CAA26096, 3848271, 3848269, 3848257, 3848293, 11720856_a_at, AC010311, 1IRK, NM_001079817, X02160_at, EntrezGene:3643, 3848254, 3848279, 3848303, ENSG00000171105, AC010526, AAA59175, 3848268, UPI0000140EE6, AK300332, ABP73389, AAA59190, 3643, g4557883_3p_a_at, DQ311687, PF00041, 3848301, Hs.208334.0.S1_3p_at, ABP68907, 33162_at, PR00109, MIM:147670, 11740018_a_at, M32837, 3848250, 65110_at, IPR006212, M32835, PF07714, PF00757, EF207612, A4ZPI3, SM00220, BC117172, 3848249, Hs.208334.0.S2_3p_s_at, ABC55359, 47628_at, IPR016246, M76592, 8033362, IPR009030, J05043, XP_006722807, 3848308, 3ETA, MIM:609968, M24555, 3848256, AAY44085, M32972, 3W13, HPA036302, XM_006722744, 226216_at, IPR003961, M32834, SM00060, IPR000719, 3848252, SLC45A4, AAC37604, DQ333193, A_23_P4764, MIM:262190, 3W14, M32830, 3848299, 3848258, IPR000494, 3848296, DQ333191, EF207609, BAD92098, Q2PJC3, M27195, ABP68900, HGNC:29196, ABP68903, M32824, 3848280, M27197, J03466, M32823, SM00261, M29930, IPR002290, HGNC:6091, 3848349, 3848278, 3848273, AAA59174, M10051, ABC46549, M32825, GE59638, 3848259, 4IBM, AAI17173, X02160, AB208861, ABC46551, INSR-002, NP_001073285, AAA59176, 3848281, 226450_at, 226212_s_at, 0002370519, M32828, AAA59452, BAG62079, 3848294, 3848264, A4ZPI5, Hs.98401.0.S1_3p_at, OTTHUMP00000268022, Hs.89695.2.A1_3p_at, PF00069, 3848262, Q2MKP2, 3848267, AC010606, A4ZPI7, EF207607, CCDS42487, 11720858_a_at, MIM:125853, M32826, 2AUH, 1RQQ, AAA59178, M32841, 3W11, 1P14, 3848292, 3BU6, M32840, EF207611, 3848255, 3848270, M10051_s_at, IPR020635, 11740017_a_at, uc002mgd.1, UPI000020324D, XP_006722806, NM_000208, ENSP00000303830, 3848350, 3848288, XP_005259611, OTTHUMP00000268023, INSR-001, CCDS12176, NP_000199
Molecules with this sequenceINSR(28-758) [plasma membrane] UKENBCdOOOOOOORHPGPPPPPPPPURDDDDDDDD
INSR(763-1382) [plasma membrane] UKENBCdOOOOOOORHPGPPPPPPPPURDDDDDDDD
p-6Y-INSR(763-1382) [plasma membrane] UKENBCdOOOOOOORHPGPPPPPPPPURDDDDDDDD
INSR(28-758) [endosome membrane] UKENBCdOOOOOOORHPGPPPPPPPPURDDDDDDDD
p-6Y-INSR(763-1382) [endosome membrane] UKENBCdOOOOOOORHPGPPPPPPPPURDDDDDDDD
INSR(763-1382) [endosome membrane] UKENBCdOOOOOOORHPGPPPPPPPPURDDDDDDDD
Tyr972
phospho-NPEY
Component ofphospho-insulin receptor [plasma membrane]
Insulin receptor [plasma membrane]
insulin receptor [endosome membrane]
phospho-insulin receptor [endosome membrane]
activated insulin receptor [plasma membrane]
insulin:insulin receptor [plasma membrane]
activated insulin receptor [endosome membrane]
SHC:activated insulin receptor [plasma membrane]
phospho-SHC: activated insulin receptor [plasma membrane]
phospho-IRS:activated insulin receptor [plasma membrane]
...
List all 12 items
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 1158
O4'-phospho-L-tyrosine at 1162
O4'-phospho-L-tyrosine at 1163
O4'-phospho-L-tyrosine at 1328
O4'-phospho-L-tyrosine at 1330
O4'-phospho-L-tyrosine at 972
DomainsTyr972
phospho-NPEY
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