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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P01308
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Insulin component recommendedName: Insulin B chain /component component recommendedName: Insulin A chain /component
Links to corresponding entries in other databasesBioGPS Gene:3630
CTD Gene:3630
DOCK Blaster:1A7F
DOCK Blaster:1AI0
DOCK Blaster:1AIY
DOCK Blaster:1B9E
DOCK Blaster:1BEN
DOCK Blaster:1EFE
DOCK Blaster:1EV3
DOCK Blaster:1EV6
DOCK Blaster:1EVR
DOCK Blaster:1FU2
DOCK Blaster:1FUB
DOCK Blaster:1G7A
DOCK Blaster:1G7B
DOCK Blaster:1GUJ
DOCK Blaster:1HIQ
DOCK Blaster:1HIS
DOCK Blaster:1HIT
DOCK Blaster:1HLS
DOCK Blaster:1HTV
DOCK Blaster:1HUI
DOCK Blaster:1IOG
DOCK Blaster:1IOH
DOCK Blaster:1J73
DOCK Blaster:1JCA
DOCK Blaster:1JCO
DOCK Blaster:1K3M
DOCK Blaster:1KMF
DOCK Blaster:1LKQ
DOCK Blaster:1LPH
DOCK Blaster:1MHI
DOCK Blaster:1MHJ
DOCK Blaster:1MSO
DOCK Blaster:1OS3
DOCK Blaster:1OS4
DOCK Blaster:1QIY
DOCK Blaster:1QIZ
DOCK Blaster:1QJ0
DOCK Blaster:1RWE
DOCK Blaster:1SJT
DOCK Blaster:1SJU
DOCK Blaster:1T0C
DOCK Blaster:1T1K
DOCK Blaster:1T1P
DOCK Blaster:1T1Q
DOCK Blaster:1TRZ
DOCK Blaster:1TYL
DOCK Blaster:1TYM
DOCK Blaster:1UZ9
DOCK Blaster:1VKT
DOCK Blaster:1W8P
DOCK Blaster:1XDA
DOCK Blaster:1XGL
DOCK Blaster:1XW7
DOCK Blaster:1ZEG
DOCK Blaster:1ZEH
DOCK Blaster:1ZNJ
DOCK Blaster:2AIY
DOCK Blaster:2C8Q
DOCK Blaster:2C8R
DOCK Blaster:2CEU
DOCK Blaster:2HIU
DOCK Blaster:2JMN
DOCK Blaster:3AIY
DOCK Blaster:4AIY
DOCK Blaster:5AIY
ENSEMBL:ENSG00000129965
GeneCards:P01308
HapMap:NM_000207
KEGG Gene:3630
NCBI Gene:3630
OMIM:176730
Protein Data Bank:1A7F
Protein Data Bank:1AI0
Protein Data Bank:1AIY
Protein Data Bank:1B9E
Protein Data Bank:1BEN
Protein Data Bank:1EFE
Protein Data Bank:1EV3
Protein Data Bank:1EV6
Protein Data Bank:1EVR
Protein Data Bank:1FU2
Protein Data Bank:1FUB
Protein Data Bank:1G7A
Protein Data Bank:1G7B
Protein Data Bank:1GUJ
Protein Data Bank:1HIQ
Protein Data Bank:1HIS
Protein Data Bank:1HIT
Protein Data Bank:1HLS
Protein Data Bank:1HTV
Protein Data Bank:1HUI
Protein Data Bank:1IOG
Protein Data Bank:1IOH
Protein Data Bank:1J73
Protein Data Bank:1JCA
Protein Data Bank:1JCO
Protein Data Bank:1K3M
Protein Data Bank:1KMF
Protein Data Bank:1LKQ
Protein Data Bank:1LPH
Protein Data Bank:1MHI
Protein Data Bank:1MHJ
Protein Data Bank:1MSO
Protein Data Bank:1OS3
Protein Data Bank:1OS4
Protein Data Bank:1QIY
Protein Data Bank:1QIZ
Protein Data Bank:1QJ0
Protein Data Bank:1RWE
Protein Data Bank:1SJT
Protein Data Bank:1SJU
Protein Data Bank:1T0C
Protein Data Bank:1T1K
Protein Data Bank:1T1P
Protein Data Bank:1T1Q
Protein Data Bank:1TRZ
Protein Data Bank:1TYL
Protein Data Bank:1TYM
Protein Data Bank:1UZ9
Protein Data Bank:1VKT
Protein Data Bank:1W8P
Protein Data Bank:1XDA
Protein Data Bank:1XGL
Protein Data Bank:1XW7
Protein Data Bank:1ZEG
Protein Data Bank:1ZEH
Protein Data Bank:1ZNJ
Protein Data Bank:2AIY
Protein Data Bank:2C8Q
Protein Data Bank:2C8R
Protein Data Bank:2CEU
Protein Data Bank:2HIU
Protein Data Bank:2JMN
Protein Data Bank:3AIY
Protein Data Bank:4AIY
Protein Data Bank:5AIY
RefSeq:NM_000207
RefSeq:NP_000198
UCSC human:P01308
UniProt:P01308
dbSNP Gene:3630
Other identifiers related to this sequenceINS_HUMAN, Q5EEX2, ENSG00000129965, ENST00000381330, ENSP00000370731, ENST00000397262, ENSP00000380432, ENST00000250971, ENSP00000250971, 1591_s_at, 202409_at, 206598_at, 210881_s_at, 202410_x_at, 36782_s_at, 1664_at, 160038_s_at, J03242_s_at, M17863_s_at, J00268_s_at, L15440_at, V00565_s_at, g182527_3p_a_at, Hs.251664.0.A2_3p_at, g4557670_3p_at, A_14_P201470, A_32_P42989, A_23_P421379, A_24_P936758, A_23_P150609, A_32_P56661, A_24_P510502, A_23_P203458, A_23_P1981, CCDS7729, GE782559, GE79183, GE59971, DQ104204, DQ104205, AY138590, AY899304, V00565, M10039, J00265, X70508, L15440, BT006808, BC005255, AJ009655, EntrezGene:723961, EntrezGene:3630, GI_6453816-S, GI_4557670-S, ILMN_22856, ILMN_14900, IPI00747044, IPI00001508, IPI00853225, MIM:176730, OTTHUMP00000196037, OTTHUMP00000196038, OTTHUMP00000011162, OTTHUMT00000026393, OTTHUMT00000315846, OTTHUMT00000026395, OTTHUMT00000026394, 1A7F, 1AI0, 1AIY, 1B9E, 1BEN, 1EFE, 1EV3, 1EV6, 1EVR, 1FU2, 1FUB, 1G7A, 1G7B, 1GUJ, 1HIQ, 1HIS, 1HIT, 1HLS, 1HTV, 1HUI, 1IOG, 1IOH, 1J73, 1JCA, 1JCO, 1K3M, 1KMF, 1LKQ, 1LPH, 1MHI, 1MHJ, 1MSO, 1OS3, 1OS4, 1QIY, 1QIZ, 1QJ0, 1RWE, 1SJT, 1SJU, 1T0C, 1T1K, 1T1P, 1T1Q, 1TRZ, 1TYL, 1TYM, 1UZ9, 1VKT, 1W8P, 1XDA, 1XGL, 1XW7, 1ZEG, 1ZEH, 1ZNJ, 2AIY, 2C8Q, 2C8R, 2CEU, 2HIU, 2JMN, 3AIY, 4AIY, 5AIY, ABD93452, ABD93453, AAN39451, AAW83741, CAA23828, AAA59173, AAA59172, CAA49913, AAA59179, AAP35454, AAH05255, CAA08766, NM_001042376, NM_000207, NP_001035835, NP_000198, Hs.694921, Hs.698284, Hs.698285, Hs.698370, Q1WM24, Q5EEX2, P01308, Q1WM24_HUMAN, Q5EEX2_HUMAN, INS_HUMAN, IPR004825
Molecules with this sequence4xHC-INS(90-110) [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
2xHC-INS(25-54) [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
INS(90-110) [endosome lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
INS(25-54) [endosome lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
6xHC-INS(25-110) [Golgi lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
INS(25-110) [endoplasmic reticulum lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
2xHC-INS(25-54) [secretory granule lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
4xHC-INS(90-110) [secretory granule lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
6xHC-INS(25-110) [secretory granule lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
INS(57-87) [secretory granule lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
6xHC-INS(25-110) [endoplasmic reticulum lumen] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
INS(57-87) [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
2xHC-Myri-INS(25-53) [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Insulin Glargine B Chain [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Insulin Glargine A Chain [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Insulin Aspart B Chain [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Insulin Humalog B Chain [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Insulin Glulisine B Chain [extracellular region] UKENBCdORHGURPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Component ofInsulin [extracellular region]
Insulin_Detemir(Levemir) [extracellular region]
Insulin Aspart (Novolog) [extracellular region]
Insulin_Humalog(Lispro) [extracellular region]
Insulin Glulisine (Apidra) [extracellular region]
insulin [endosome lumen]
6xProinsulin:2xZn2+:1xCa2+ [Golgi lumen]
Insulin [secretory granule lumen]
6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]
Insulin_Glargine [extracellular region]
...
List all 22 items
Processes where molecules and complexes with this sequence are involved

Metabolism of proteins

Signal Transduction

Metabolism

Developmental Biology

Disease

Modifications in molecules with this sequencehalf cystine at 109
half cystine at 95
half cystine at 96
half cystine at 43
half cystine at 100
half cystine at 31
L-lysine 53 replaced with L-proline
L-proline 52 replaced with L-aspartic acid
L-asparagine 110 replaced with glycine
L-proline 52 replaced with L-lysine
L-threonine 54 replaced with L-threonine - L-arginine - L-arginine
N6-myristoyl-L-lysine at 53
L-asparagine 27 replaced with L-lysine
L-lysine 53 replaced with L-glutamic acid
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