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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:O60674
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein kinase JAK2 ecNumber2.7.10.2/ecNumber alternativeName: Janus kinase 2 shortName:JAK-2
Links to corresponding entries in other databasesBioGPS Gene:3717
Brenda:2.7.10.2
CTD Gene:3717
DOCK Blaster:2B7A
EC:2.7.10.2
ENSEMBL:ENSG00000096968
GeneCards:O60674
HapMap:NM_004972
IntEnz:2.7.10.2
KEGG Gene:3717
NCBI Gene:3717
OMIM:147796
OMIM:187950
OMIM:254450
OMIM:263300
OMIM:600880
OMIM:601626
Protein Data Bank:2B7A
RefSeq:NM_004972
RefSeq:NP_004963
UCSC human:O60674
UniProt:O60674
dbSNP Gene:3717
Other identifiers related to this sequenceJAK2_HUMAN, O14636, O75297, ENSG00000096968, ENST00000381652, ENSP00000371067, 205841_at, 205842_s_at, 37468_at, 78910_i_at, 78912_r_at, g3236321_3p_a_at, g13325062_3p_at, A_14_P127099, A_14_P136058, A_14_P105543, A_23_P123608, A_23_P123610, CCDS6457, GE79112, AY973034, BC039695, AY973037, EF094945, EF194100, AL161450, AF058925, AF001362, AF005216, EntrezGene:3717, GI_13325062-S, ILMN_12566, IPI00031016, IPI00853419, MIM:147796, MIM:187950, MIM:254450, MIM:263300, MIM:600880, MIM:601626, OTTHUMT00000051609, 2B7A, AAY22962, AAH39695, AAY16348, ABK91947, ABM69254, AAC23982, AAC23653, AAB82092, CAD13329, NM_004972, NP_004963, Hs.656213, Q506Q0, Q8IXP2, Q52R86, O60674, Q506Q0_HUMAN, Q8IXP2_HUMAN, Q52R86_HUMAN, JAK2_HUMAN, IPR000719, IPR008266, IPR001245, IPR009127, IPR009129, IPR000980, IPR000299
Molecules with this sequenceJAK2 [cytosol] UKENBCdOOOOOORHGURPD
p-Y1007-JAK2 [cytosol] UKENBCdOOOOOORHGURPD
p-Y813-JAK2 [cytosol] UKENBCdOOOOOORHGURPD
JAK2 [endosome lumen] UKENBCdOOOOOORHGURPD
p-5Y-JAK2 [cytosol] UKENBCdOOOOOORHGURPD
JAK2 V617F [nucleoplasm] UKENBCdOOOOOORHGURPD
Component ofIFNGR2:JAK2 [plasma membrane]
IL3RB:JAK2 [plasma membrane]
pY593,Y628-IL3RB:JAK2 [plasma membrane]
p(Y593)-Bc:JAK2 [plasma membrane]
p-S585-IL3RB:JAK2 [plasma membrane]
Growth Hormone Receptor:JAK2 [plasma membrane]
Activated Growth Hormone Receptor:JAK2 [plasma membrane]
Tyrosine phosphorylated Growth Hormone Receptor:JAK2 [plasma membrane]
PRLR:JAK2 [plasma membrane]
p(S349)-PRLR:JAK2 [plasma membrane]
...
List all 178 items
Represented by generalisation(s)JAK1, JAK2, TYK2 [cytosol]
Activated JAK1, JAK2, TYK2 [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Immune System

Chromatin organization

Hemostasis

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 1007
O4'-phospho-L-tyrosine at 813
O4'-phospho-L-tyrosine at 1008
O4'-phospho-L-tyrosine at 972
O4'-phospho-L-tyrosine at 868
O4'-phospho-L-tyrosine at 966
O4'-phospho-L-tyrosine at 304
L-valine 617 replaced with L-phenylalanine
O4'-phospho-L-tyrosine at 307
O4'-phospho-L-tyrosine at 297
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