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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:O60674
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein kinase JAK2 ecNumber2.7.10.2/ecNumber alternativeName: Janus kinase 2 shortName:JAK-2
Links to corresponding entries in other databasesBioGPS Gene:3717
Brenda:2.7.10.2
CTD Gene:3717
DOCK Blaster:2B7A
EC:2.7.10.2
ENSEMBL:ENSG00000096968
GeneCards:O60674
HapMap:NM_004972
IntEnz:2.7.10.2
KEGG Gene:3717
NCBI Gene:3717
OMIM:147796
OMIM:187950
OMIM:254450
OMIM:263300
OMIM:600880
OMIM:601626
Orphanet:16279
PRO:O60674
Protein Data Bank:2B7A
RefSeq:NM_004972
RefSeq:NP_004963
UCSC human:O60674
UniProt:O60674
dbSNP Gene:3717
Other identifiers related to this sequenceJAK2_HUMAN, O14636, O75297, 3160950, 3160906, MIM:614521, 4E6D, SM00219, 2W1I, AAH39695, 3161009, XP_005251512, BC039695, AF001362, IPR001245, 4C61, IPR016251, 3160949, A_33_P3878772, HGNC:6192, 3160957, 3E63, 4E6Q, AL513350, 3KCK, GE79112, g3236321_3p_a_at, 3160904, 3160953, 3160937, 3160947, IPR019749, 8154178, AAB82092, SM00295, JAK2-001, 3160931, IPR011009, 4JI9, OTTHUMP00000021024, CCDS6457, NP_004963, Hs.656213, 3161019, ENSG00000096968, 3161016, MIM:263300, AF005216, AAC23653, PR01825, 3FUP, 4JIA, g13325062_3p_at, 3UGC, 3160933, A_14_P127099, MIM:601626, 4FVQ, 3160935, 11733373_at, 4E4M, EntrezGene:3717, AL158147, CAD13329, 3161014, 11756857_a_at, 4GMY, XM_005251455, 1848670, IPR000980, PR00109, 3ZMM, PR01823, PH_hs_0025325, CAB013089, uc003ziw.3, IPR000299, MIM:147796, PF07714, 4C62, 3160896, 3LPB, 3TJC, 3160960, SM00220, 37468_at, 3160962, 3160951, 0003360010, 4FVR, JAK2, AL161450, 3E64, 3160905, A_23_P123608, 2XA4, 3160936, 3160944, A_14_P105543, 3160958, 4F08, ENST00000381652, 3IOK, 3160956, 3RVG, IPR000719, 3E62, 3160898, 3JY9, 2B7A, 3161013, LRG_612, NM_004972, SM00252, ENSP00000371067, 4BBE, 17083319, PF00017, 3160932, IPR002290, 4HGE, 3160907, UPI000012DA9E, 3IO7, LRG_612t1, AAC23982, Q8IXP2, F5H5U8, MIM:254450, 3Q32, 3717, 3TJD, MIM:600880, 4AQC, IPR019748, A_14_P136058, 205842_s_at, 4BBF, PF00069, 3160946, 3161017, 4FVP, IPR020693, 3160899, ILMN_1683178, 4IVA, 3KRR, 3161015, 4GFM, 78910_i_at, 4F09, 205841_at, 3160897, 3160963, AF058925, IPR020635, 11733372_a_at, 3160941
Molecules with this sequenceJAK2 [cytosol] UKENBCdOOOOOOORHPGPURD
p-Y1007-JAK2 [cytosol] UKENBCdOOOOOOORHPGPURD
p-Y813-JAK2 [cytosol] UKENBCdOOOOOOORHPGPURD
JAK2 [endosome lumen] UKENBCdOOOOOOORHPGPURD
p-5Y-JAK2 [cytosol] UKENBCdOOOOOOORHPGPURD
JAK2 V617F [nucleoplasm] UKENBCdOOOOOOORHPGPURD
Component ofIFNGR2:JAK2 [plasma membrane]
IL3RB:JAK2 [plasma membrane]
pY593,Y628-IL3RB:JAK2 [plasma membrane]
p(Y593)-Bc:JAK2 [plasma membrane]
p-S585-IL3RB:JAK2 [plasma membrane]
Growth Hormone Receptor:JAK2 [plasma membrane]
Activated Growth Hormone Receptor:JAK2 [plasma membrane]
Tyrosine phosphorylated Growth Hormone Receptor:JAK2 [plasma membrane]
PRLR:JAK2 [plasma membrane]
p(S349)-PRLR:JAK2 [plasma membrane]
...
List all 178 items
Represented by generalisation(s)JAK1, JAK2, TYK2 [cytosol]
Activated JAK1, JAK2, TYK2 [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Immune System

Chromatin organization

Hemostasis

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 1007
O4'-phospho-L-tyrosine at 813
O4'-phospho-L-tyrosine at 1008
O4'-phospho-L-tyrosine at 972
O4'-phospho-L-tyrosine at 868
O4'-phospho-L-tyrosine at 966
O4'-phospho-L-tyrosine at 304
L-valine 617 replaced with L-phenylalanine
O4'-phospho-L-tyrosine at 307
O4'-phospho-L-tyrosine at 297
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