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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:Q02750
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Dual specificity mitogen-activated protein kinase kinase 1 shortName:MAP kinase kinase 1 shortName:MAPKK 1 shortName:MKK1 ecNumber2.7.12.2/ecNumber alternativeName: ERK activator kinase 1 alternativeName: MAPK/ERK kinase 1 shortName:MEK 1
Links to corresponding entries in other databasesBioGPS Gene:5604
Brenda:2.7.12.2
CTD Gene:5604
DOCK Blaster:1S9J
EC:2.7.12.2
ENSEMBL:ENSG00000169032
GeneCards:Q02750
HapMap:NM_002755
IntEnz:2.7.12.2
KEGG Gene:5604
NCBI Gene:5604
OMIM:176872
Protein Data Bank:1S9J
RefSeq:NM_002755
RefSeq:NP_002746
UCSC human:Q02750
UniProt:Q02750
dbSNP Gene:5604
Other identifiers related to this sequenceMP2K1_HUMAN, ENSG00000169032, ENST00000307102, ENSP00000302486, 1130_at, 1844_s_at, 202670_at, 214592_s_at, L11284_at, L05624_s_at, Hs.3446.0.A2_3p_at, Hs.30174.1.S2_3p_at, A_23_P20248, A_32_P406652, A_32_P189110, CCDS10216, GE57608, BC139729, L05624, L11284, EntrezGene:5604, GI_14589898-S, ILMN_19662, IPI00219604, MIM:176872, 1S9J, AAI39730, AAA36318, NM_002755, NP_002746, OTTHUMT00000256906, Hs.145442, A4QPA9, Q02750, A4QPA9_HUMAN, MP2K1_HUMAN, IPR000719, IPR008271, IPR001245
Molecules with this sequenceMAP2K1 [cytosol] UKENBCdORHGURPD
p-S218,S222-MAP2K1 [cytosol] UKENBCdORHGURPD
p-S218,S222,T286,T292-MAP2K1 [cytosol] UKENBCdORHGURPD
p-T286,T292-MAP2K1 [cytosol] UKENBCdORHGURPD
MAP2K1(2-8) [cytosol] UKENBCdORHGURPD
MAP2K1(9-393) [cytosol] UKENBCdORHGURPD
proline-rich domain
Component ofActivated RAF1 complex:MEK [plasma membrane]
Activated RAF1 complex:MEK1 [plasma membrane]
MEK1:ERK-1 [cytosol]
phospho-ERK-1:MEK1 [cytosol]
Represented by generalisation(s)MEK1 [cytosol]
MEK [cytosol]
MEK1, SEK1 [cytosol]
Phospho-MEK [cytosol]
Phospho-MEK1, phospho-SEK1 [cytosol]
p-MEK1 [cytosol]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

Developmental Biology

Disease

TRAF6 Mediated Induction of proinflammatory cytokines

Modifications in molecules with this sequenceO-phospho-L-serine at 218
O-phospho-L-serine at 222
O-phospho-L-threonine at 286
O-phospho-L-threonine at 292
Domainsproline-rich domain
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