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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:Q02750
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Dual specificity mitogen-activated protein kinase kinase 1 shortName:MAP kinase kinase 1 shortName:MAPKK 1 shortName:MKK1 ecNumber2.7.12.2/ecNumber alternativeName: ERK activator kinase 1 alternativeName: MAPK/ERK kinase 1 shortName:MEK 1
Links to corresponding entries in other databasesBioGPS Gene:5604
Brenda:2.7.12.2
CTD Gene:5604
DOCK Blaster:1S9J
EC:2.7.12.2
ENSEMBL:ENSG00000169032
GeneCards:Q02750
HapMap:NM_002755
IntEnz:2.7.12.2
KEGG Gene:5604
NCBI Gene:5604
OMIM:176872
Orphanet:16377
PRO:Q02750
Protein Data Bank:1S9J
RefSeq:NM_002755
RefSeq:NP_002746
UCSC human:Q02750
UniProt:Q02750
ZINC_target:Q02750
dbSNP Gene:5604
Other identifiers related to this sequenceMP2K1_HUMAN, 1S9J, OTTHUMP00000164252, HPA026430, BC137459, L11284, PF07714, MAP2K1-001, 5604, SM00219, 3V04, 4AN2, SM00220, NM_002755, BC139729, L05624, uc010bhq.3, 3EQI, 1844_s_at, 3SLS, 3E8N, 3092264, 11717291_a_at, 3598663, 3092255, IPR001245, 4AN3, 3598700, 3598696, 16802190, 3598688, EntrezGene:5604, 4LMN, 3598664, ENSG00000169032, L05624_s_at, 3DV3, AAI37460, MIM:615279, 3598692, ILMN_1694240, 8388392, 3ZLS, HGNC:6840, IPR000719, 3DY7, 3ZLY, BAF84189, A4QPA9, 4ANB, 3598702, 3MBL, 3598691, AAI39730, ENSP00000302486, 202670_at, 3VVH, 3598701, 3598690, GE57608, IPR002290, PH_hs_0022483, IPR011009, 1130_at, 3OS3, 3ZM4, 4ARK, 3598672, MAP2K1, 0001740347, 3598673, 3ZLX, CAB003834, 7984319, 3598697, 3ZLW, 2P55, Hs.689729, CCDS10216, 3092256, 4AN9, 11749555_a_at, Hs.3446.0.A2_3p_at, 3EQG, UPI000013EBC9, EAW77765, CH471082, 3ORN, PF00069, 3V01, NP_002746, 3598671, 9465908, AAA36318, 3EQH, 11757478_s_at, 3EQC, AK291500, 3EQD, 3W8Q, Hs.145442, 3EQF, 3598670, 3PP1, MIM:176872, L11284_at, 3EQB, PR00109, A_23_P20248, IPR020635
Molecules with this sequenceMAP2K1 [cytosol] UKENBCdOORHPGPURDZ
p-S218,S222-MAP2K1 [cytosol] UKENBCdOORHPGPURDZ
p-S218,S222,T286,T292-MAP2K1 [cytosol] UKENBCdOORHPGPURDZ
p-T286,T292-MAP2K1 [cytosol] UKENBCdOORHPGPURDZ
MAP2K1(2-8) [cytosol] UKENBCdOORHPGPURDZ
MAP2K1(9-393) [cytosol] UKENBCdOORHPGPURDZ
proline-rich domain
Component ofActivated RAF1 complex:MEK [plasma membrane]
Activated RAF1 complex:MEK1 [plasma membrane]
MEK1:ERK-1 [cytosol]
phospho-ERK-1:MEK1 [cytosol]
Represented by generalisation(s)MEK1 [cytosol]
MEK [cytosol]
MEK1, SEK1 [cytosol]
Phospho-MEK [cytosol]
Phospho-MEK1, phospho-SEK1 [cytosol]
p-MEK1 [cytosol]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

Developmental Biology

Disease

TRAF6 Mediated Induction of proinflammatory cytokines

Modifications in molecules with this sequenceO-phospho-L-serine at 218
O-phospho-L-serine at 222
O-phospho-L-threonine at 286
O-phospho-L-threonine at 292
Domainsproline-rich domain
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