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Details
IdentifierUniProt:P46531
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Neurogenic locus notch homolog protein 1 shortName:Notch 1 shortName:hN1 alternativeName: Translocation-associated notch protein TAN-1 component recommendedName: Notch 1 extracellular truncation shortName:NEXT /component component recommendedName: Notch 1 intracellular domain shortName:NICD /component
Links to corresponding entries in other databasesDOCK Blaster:1PB5
DOCK Blaster:1TOZ
DOCK Blaster:1YYH
DOCK Blaster:2F8X
DOCK Blaster:2F8Y
ENSEMBL:ENSG00000148400
GeneCards:P46531
KEGG Gene:4851
OMIM:190198
Orphanet:16434
PRO:P46531
Protein Data Bank:1PB5
Protein Data Bank:1TOZ
Protein Data Bank:1YYH
Protein Data Bank:2F8X
Protein Data Bank:2F8Y
UCSC human:P46531
UniProt:P46531
Other identifiers related to this sequenceNOTC1_HUMAN, Q59ED8, Q5SXM3, 3230194, 3230183, 3230169, 3230167, PF07974, MIM:109730, NP_060087, 1831692, CAI13934, IPR001881, 11718261_at, H9CXX2, IPR020683, W5VTT0, uc004chz.3, AAA60614, 3230203, 3230144, CAI16149, 3230189, 3230180, PF00023, 3230143, SM00004, 2F8Y, PR00011, 3230170, 1YYH, UPI0000210F68, 3230172, PF07645, IPR022362, IPR008297, 3230152, AAG33848, 3ETO, 3230157, IPR011656, A_23_P60387, PR01984, NM_017617, Hs.495473, 76569_at, 2VJ3, 8165217, 3230176, 3230185, 3230159, EntrezGene:4851, 3230220, IPR024600, 3230202, 223508_at, JQ429585, AHH85782, AL592301, 3230166, IPR013111, AF308602, AFD64628, ENSG00000148400, g8923012_3p_at, 3230219, 3I08, CAB008112, M73980, PR01452, 17100036, OTTHUMP00000022594, NOTCH1, IPR000800, 3L95, 2F8X, CCDS43905, 1TOZ, SM00179, 3230168, 3230171, PF00008, 2HE0, PF06816, A_33_P3370424, 3230188, 3230145, 3230142, KF814727, 11718260_at, HGNC:7881, 3230198, 3230181, CAB022466, MIM:190198, BAD93110, PR01983, 65751_at, AB209873, 3230186, PF07684, 218902_at, 3230163, 3230165, 3230177, SM00248, 11718259_at, 3V79, 0004280056, 1PB5, IPR002110, 3230190, NOTCH1-001, 3NBN, 3230158, ILMN_1729161, SM00181, 4851, 86254_r_at, IPR000742, AL354671, PF11936, GE82183, 3230193, 3230160, PH_hs_0023725, IPR010660, 3230187, ENSP00000277541, 3230154, 3230196
Molecules with this sequencePre-NOTCH1 [endoplasmic reticulum membrane] UKEOOPGPPPPPUDDDDD
NOTCH1(1665-2555) [Golgi membrane] UKEOOPGPPPPPUDDDDD
NEXT1 [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1(1665-2555) [plasma membrane] UKEOOPGPPPPPUDDDDD
NICD1 [cytosol] UKEOOPGPPPPPUDDDDD
NOTCH1(1665-1720) [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1(1721-1753) [plasma membrane] UKEOOPGPPPPPUDDDDD
NICD1 [nucleoplasm] UKEOOPGPPPPPUDDDDD
17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] UKEOOPGPPPPPUDDDDD
19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] UKEOOPGPPPPPUDDDDD
17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 L1574P Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 L1593P Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 A1701P Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 L1678P Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 R1598P Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 Q2395* Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
p-NICD1 [nucleoplasm] UKEOOPGPPPPPUDDDDD
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] UKEOOPGPPPPPUDDDDD
Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] UKEOOPGPPPPPUDDDDD
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] UKEOOPGPPPPPUDDDDD
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] UKEOOPGPPPPPUDDDDD
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] UKEOOPGPPPPPUDDDDD
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] UKEOOPGPPPPPUDDDDD
17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] UKEOOPGPPPPPUDDDDD
p-NICD1 P2514Rfs*4 [nucleoplasm] UKEOOPGPPPPPUDDDDD
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 L1600P Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 F1592S Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 V1576E Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 L1596H Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 I1616N Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 I1616T Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 I1680N Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 V1676D Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 I1718T Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 L1574Q Extracellular Fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 A1701P S2 cleavage fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NOTCH1 I1680N S2 cleavage fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 L1678P S2 cleavage fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 V1676D S2 cleavage fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 I1718T S2 cleavage fragment [extracellular region] UKEOOPGPPPPPUDDDDD
NOTCH1 P2514Rfs*4 Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NEXT1 P2514Rfs*4 [plasma membrane] UKEOOPGPPPPPUDDDDD
NICD1 P2514Rfs*4 [cytosol] UKEOOPGPPPPPUDDDDD
NICD1 P2514Rfs*4 [nucleoplasm] UKEOOPGPPPPPUDDDDD
NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] UKEOOPGPPPPPUDDDDD
NICD1 Q2440* [cytosol] UKEOOPGPPPPPUDDDDD
NEXT1 Q2395* [plasma membrane] UKEOOPGPPPPPUDDDDD
NICD1 P2474Afs*4 [cytosol] UKEOOPGPPPPPUDDDDD
NEXT1 P2474Afs*4 [plasma membrane] UKEOOPGPPPPPUDDDDD
NICD1 Q2395* [cytosol] UKEOOPGPPPPPUDDDDD
NEXT1 Q2440* [plasma membrane] UKEOOPGPPPPPUDDDDD
NICD1 Q2440* [nucleoplasm] UKEOOPGPPPPPUDDDDD
NICD1 Q2395* [nucleoplasm] UKEOOPGPPPPPUDDDDD
p-NICD1 P2474Afs*4 [nucleoplasm] UKEOOPGPPPPPUDDDDD
p-NICD1 Q2395* [nucleoplasm] UKEOOPGPPPPPUDDDDD
p-NICD1 Q2440* [nucleoplasm] UKEOOPGPPPPPUDDDDD
NICD1 P2474Afs*4 [nucleoplasm] UKEOOPGPPPPPUDDDDD
Component ofNOTCH1 [Golgi membrane]
FRINGE-modified NOTCH1 [Golgi membrane]
NOTCH1 [plasma membrane]
Fringe-modified NOTCH1 [plasma membrane]
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) [plasma membrane]
NOTCH1 R1598P [plasma membrane]
NOTCH1 L1593P [plasma membrane]
NOTCH1 L1574P [plasma membrane]
NOTCH1 L1600P [plasma membrane]
NOTCH1 V1576E [plasma membrane]
...
List all 107 items
Represented by generalisation(s)Pre-NOTCH [endoplasmic reticulum membrane]
NICD [nucleoplasm]
Fuc-Pre-NOTCH [endoplasmic reticulum membrane]
Glc,Fuc-Pre-NOTCH [endoplasmic reticulum membrane]
Glc,Fuc-Pre-NOTCH [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Glc,GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
p-NICD1 PEST domain mutants [nucleoplasm]
NEXT1 PEST domain mutants [plasma membrane]
NICD1 PEST Domain Mutants [cytosol]
NICD1 PEST Domain Mutants [nucleoplasm]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Gene Expression

Disease

A third proteolytic cleavage releases NICD

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

rDll1 binds NOTCH1 in cis [Homo sapiens]

NICD1 displaces NCOR co-repressor complex from CSL [Cercopithecus aethiops]

NICD traffics to nucleus

Modifications in molecules with this sequenceO-glucosyl-L-serine at 534
O-glucosyl-L-serine at 496
O-fucosyl-L-threonine at 1197
O-fucosyl-L-threonine at 1402
O-fucosyl-L-threonine at 73
O-fucosyl-L-threonine at 194
O-fucosyl-L-threonine at 767
O-fucosyl-L-threonine at 1362
O-fucosyl-L-threonine at 1243
O-fucosyl-L-threonine at 997
O-glucosyl-L-serine at 458
O-glucosyl-L-serine at 1065
O-fucosyl-L-threonine at 1321
O-fucosyl-L-threonine at 311
O-fucosyl-L-threonine at 1159
O-glucosyl-L-serine at 797
O-fucosyl-L-threonine at 692
O-glucosyl-L-serine at 647
O-fucosyl-L-threonine at 466
O-glucosyl-L-serine at 1189
O-glucosyl-L-serine at 1027
O-fucosyl-L-threonine at 805
O-glucosyl-L-serine at 722
O-glucosyl-L-serine at 1273
O-fucosyl-L-threonine at 349
O-glucosyl-L-serine at 759
O-fucosyl-L-threonine at 116
O-glucosyl-L-serine at 378
O-glucosyl-L-serine at 146
O-fucosyl-L-serine at 921
O-fucosyl-L-threonine at 1035
O-fucosyl-L-serine at 883
O-glucosyl-L-serine at 609
O-fucosyl-L-threonine at 232
O-glucosyl-L-serine at 65
O-fucosyl-L-threonine at 617
O-glucosyl-L-serine at 951
L-arginine 1598 replaced with L-proline
L-alanine 1701 replaced with L-proline
L-leucine 1593 replaced with L-proline
L-leucine 1678 replaced with L-proline
L-leucine 1574 replaced with L-proline
L-proline 2514 replaced with L-arginine
L-glutamic acid 2515 replaced with L-valine
L-serine 2516 replaced with L-proline
L-leucine 1600 replaced with L-proline
O-phospho-L-serine at unknown position
O-fucosyl-L-threonine (beta- D- galactopyranosyl- (1?4)- 2- acetamido- 2- deoxy- beta- D- glucopyranosyl- (1?3)- 6- deoxy- alpha- L- galactopyranosyl group) at unknown position
O-fucosyl-L-threonine (N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl group) at unknown position
O-fucosyl-L-threonine (alpha- N- acetylneuraminyl- (2?3)- beta- D- galactopyranosyl- (1?4)- 2- acetamido- 2- deoxy- ?- D- glucopyranosyl- (1?3)- 6- deoxy- alpha- L- galactopyranosyl group) at unknown position
L-phenylalanine 1592 replaced with L-serine
L-leucine 1596 replaced with L-histidine
L-valine 1576 replaced with L-glutamic acid
L-isoleucine 1616 replaced with L-threonine
L-isoleucine 1616 replaced with L-asparagine
L-isoleucine 1680 replaced with L-asparagine
L-valine 1676 replaced with L-aspartic acid
L-isoleucine 1718 replaced with L-threonine
L-leucine 1574 replaced with L-glutamine
L-proline 2474 replaced with L-alanine
L-valine 2476 replaced with L-proline
L-proline 2475 replaced with L-histidine
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