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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
SpeciesHomo sapiens
DescriptionrecommendedName: Neurogenic locus notch homolog protein 3 shortName:Notch 3 component recommendedName: Notch 3 extracellular truncation /component component recommendedName: Notch 3 intracellular domain /component
Links to corresponding entries in other databasesBioGPS Gene:4854
CTD Gene:4854
KEGG Gene:4854
NCBI Gene:4854
UCSC human:Q9UM47
dbSNP Gene:4854
Other identifiers related to this sequenceNOTC3_HUMAN, Q9UEB3, Q9UPL3, Q9Y6L8, NP_000426, EntrezGene:4854, GE79373, 3853120, PF07974, PR01986, AF058886, 3853113, 3853153, 38750_at, 3853161, 3853131, AF058897, 11716569_at, IPR001881, HGNC:7883, A_24_P399606, AF058893, AF058882, IPR020683, 3853127, PF00066, 3853139, 3853157, AC004663, 3853111, 3853150, 3853159, 3853163, PF00023, AF058896, SM00004, 3853124, 3853128, AF058883, PR00011, AAC15789, AF058890, OTTHUMP00000271209, MIM:125310, 203238_s_at, AF058887, CCDS12326, PF07645, IPR008297, 0001990315, 3853148, 3853116, IPR011656, 3853119, 11716570_a_at, 3853168, uc002nan.3, AC004257, AF058892, 3853154, 3853134, 3853135, 3853117, 3853141, 3853174, NOTCH3-001, 3853166, IPR024600, MIM:600276, Hs.8546.0.A1_3p_a_at, NM_000435, NOTCH3, IPR022331, 3853145, A_33_P3313055, 3853137, 203237_s_at, 3853146, 3853123, 3853143, AF058898, 3853114, IPR013111, 3853160, 7835890, 3853170, g4557798_3p_a_at, 3853162, 3853158, AAB91371, 3853130, AF058900, PR01452, 3853121, AF058889, 3853175, 3853126, IPR000800, 3853112, AAC04897, 3853151, 4854, UPI000013D3FA, SM00179, HPA044392, AF058885, U97669, PF00008, PF06816, 3853164, 3853138, AF058894, ENSG00000074181, 3853129, 3853167, AF058884, PR01983, 3853118, PF07684, AF058895, 8034940, SM00248, PR00010, AF058888, 3853173, Hs.735005, AF058899, 3853140, IPR002110, 3853115, 3853169, 16869769, CAB005393, ILMN_1755832, AAC14346, SM00181, AF058881, 3853136, IPR000742, ENSP00000263388, 3853152, PF11936, 3853147, PH_hs_0000907, ILMN_1658926, 3853142, IPR010660, MIM:615293, 3853133, Hs.8546, 3853122, AF058891
Molecules with this sequenceNOTCH3(1572-2321) [Golgi membrane] UKENBCdOOORHPGUR
Pre-NOTCH3 [endoplasmic reticulum membrane] UKENBCdOOORHPGUR
NEXT3 [plasma membrane] UKENBCdOOORHPGUR
NOTCH3(1572-2321) [plasma membrane] UKENBCdOOORHPGUR
NOTCH3(40-1628) [extracellular region] UKENBCdOOORHPGUR
NOTCH3(1629-1661) [plasma membrane] UKENBCdOOORHPGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] UKENBCdOOORHPGUR
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] UKENBCdOOORHPGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] UKENBCdOOORHPGUR
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] UKENBCdOOORHPGUR
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] UKENBCdOOORHPGUR
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] UKENBCdOOORHPGUR
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] UKENBCdOOORHPGUR
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] UKENBCdOOORHPGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] UKENBCdOOORHPGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] UKENBCdOOORHPGUR
Component ofCSL NICD coactivator complex [nucleoplasm]
DLL/JAG:NOTCH3 [plasma membrane]
FRINGE-modified NOTCH3 [Golgi membrane]
Fringe-modified NOTCH3 [plasma membrane]
NOTCH3 [Golgi membrane]
NOTCH3 [plasma membrane]
NOTCH3 Coactivator Complex [nucleoplasm]
NOTCH3 fragment:DLL/JAG [plasma membrane]
Represented by generalisation(s)Pre-NOTCH [endoplasmic reticulum membrane]
NICD [nucleoplasm]
Glc,Fuc-Pre-NOTCH [endoplasmic reticulum membrane]
Fuc-Pre-NOTCH [endoplasmic reticulum membrane]
Glc,Fuc-Pre-NOTCH [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Glc,GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Processes where molecules and complexes with this sequence are involved

A third proteolytic cleavage releases NICD

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Signal Transduction

Gene Expression

NICD traffics to nucleus

Modifications in molecules with this sequenceO-fucosyl-L-threonine at 748
O-fucosyl-L-threonine at 445
O-glucosyl-L-serine at 513
O-glucosyl-L-serine at 1252
O-fucosyl-L-threonine at 211
O-glucosyl-L-serine at 663
O-fucosyl-L-serine at 671
O-glucosyl-L-serine at 125
O-glucosyl-L-serine at 437
O-glucosyl-L-serine at 588
O-glucosyl-L-serine at 84
O-fucosyl-L-threonine at 328
O-glucosyl-L-serine at 968
O-fucosyl-L-serine at 1136
O-fucosyl-L-threonine at 1181
O-glucosyl-L-serine at 740
O-fucosyl-L-threonine at 173
O-fucosyl-L-threonine at 938
O-fucosyl-L-threonine at 250
O-fucosyl-L-threonine at 1098
O-glucosyl-L-serine at 357
O-glucosyl-L-serine at 1128
O-glucosyl-L-serine at 475
O-fucosyl-L-threonine at 290
O-glucosyl-L-serine at 893
O-fucosyl-L-serine at 863
O-glucosyl-L-serine at 626
O-fucosyl-L-serine at 1349
O-fucosyl-L-threonine (N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl group) at unknown position
O-fucosyl-L-threonine (alpha- N- acetylneuraminyl- (2?3)- beta- D- galactopyranosyl- (1?4)- 2- acetamido- 2- deoxy- ?- D- glucopyranosyl- (1?3)- 6- deoxy- alpha- L- galactopyranosyl group) at unknown position
O-fucosyl-L-threonine (beta- D- galactopyranosyl- (1?4)- 2- acetamido- 2- deoxy- beta- D- glucopyranosyl- (1?3)- 6- deoxy- alpha- L- galactopyranosyl group) at unknown position
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