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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
SpeciesHomo sapiens
DescriptionrecommendedName: Neurogenic locus notch homolog protein 3 shortName:Notch 3 component recommendedName: Notch 3 extracellular truncation /component component recommendedName: Notch 3 intracellular domain /component
Links to corresponding entries in other databasesBioGPS Gene:4854
CTD Gene:4854
KEGG Gene:4854
NCBI Gene:4854
UCSC human:Q9UM47
dbSNP Gene:4854
Other identifiers related to this sequenceNOTC3_HUMAN, Q9UEB3, Q9UPL3, Q9Y6L8, ENSG00000074181, ENST00000263388, ENSP00000263388, 203238_s_at, 203237_s_at, 38750_at, X79439_at, g4557798_3p_a_at, Hs.8546.0.A1_3p_a_at, A_14_P103283, A_32_P42895, A_24_P399606, A_23_P108201, A_32_P45014, CCDS12326, GE79373, U97669, AF058900, AF058881, AF058882, AF058883, AF058884, AF058885, AF058886, AF058887, AF058888, AF058889, AF058890, AF058891, AF058892, AF058893, AF058894, AF058895, AF058896, AF058897, AF058898, AF058899, AC004257, AC004663, EntrezGene:4854, GI_4557798-S, ILMN_12369, IPI00029819, MIM:600276, MIM:125310, AAB91371, AAC14346, AAC04897, AAC15789, NM_000435, NP_000426, Hs.8546, Q9UM47, NOTC3_HUMAN, IPR000152, IPR001881, IPR013032, IPR000800, IPR001438, IPR002049, IPR002110, IPR006209, IPR010660, IPR011656, IPR013091, IPR013111, IPR000694, IPR000742
Molecules with this sequenceNOTCH3(1572-2321) [Golgi membrane] UKENBCdOORHGUR
Pre-NOTCH3 [endoplasmic reticulum membrane] UKENBCdOORHGUR
NEXT3 [plasma membrane] UKENBCdOORHGUR
NOTCH3(1572-2321) [plasma membrane] UKENBCdOORHGUR
NOTCH3(40-1628) [extracellular region] UKENBCdOORHGUR
NOTCH3(1629-1661) [plasma membrane] UKENBCdOORHGUR
NICD3 [nucleoplasm] UKENBCdOORHGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] UKENBCdOORHGUR
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] UKENBCdOORHGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] UKENBCdOORHGUR
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] UKENBCdOORHGUR
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] UKENBCdOORHGUR
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] UKENBCdOORHGUR
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] UKENBCdOORHGUR
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] UKENBCdOORHGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] UKENBCdOORHGUR
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] UKENBCdOORHGUR
Component ofCSL NICD coactivator complex [nucleoplasm]
DLL/JAG:NOTCH3 [plasma membrane]
FRINGE-modified NOTCH3 [Golgi membrane]
Fringe-modified NOTCH3 [plasma membrane]
NOTCH3 [Golgi membrane]
NOTCH3 [plasma membrane]
NOTCH3 Coactivator Complex [nucleoplasm]
NOTCH3 fragment:DLL/JAG [plasma membrane]
Represented by generalisation(s)Pre-NOTCH [endoplasmic reticulum membrane]
NICD [nucleoplasm]
Glc,Fuc-Pre-NOTCH [endoplasmic reticulum membrane]
Fuc-Pre-NOTCH [endoplasmic reticulum membrane]
Glc,Fuc-Pre-NOTCH [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Glc,GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane]
Processes where molecules and complexes with this sequence are involved

A third proteolytic cleavage releases NICD

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Signal Transduction

Gene Expression

NICD traffics to nucleus

Modifications in molecules with this sequenceO-fucosyl-L-threonine at 748
O-fucosyl-L-threonine at 445
O-glucosyl-L-serine at 513
O-glucosyl-L-serine at 1252
O-fucosyl-L-threonine at 211
O-glucosyl-L-serine at 663
O-fucosyl-L-serine at 671
O-glucosyl-L-serine at 125
O-glucosyl-L-serine at 437
O-glucosyl-L-serine at 588
O-glucosyl-L-serine at 84
O-fucosyl-L-threonine at 328
O-glucosyl-L-serine at 968
O-fucosyl-L-serine at 1136
O-fucosyl-L-threonine at 1181
O-glucosyl-L-serine at 740
O-fucosyl-L-threonine at 173
O-fucosyl-L-threonine at 938
O-fucosyl-L-threonine at 250
O-fucosyl-L-threonine at 1098
O-glucosyl-L-serine at 357
O-glucosyl-L-serine at 1128
O-glucosyl-L-serine at 475
O-fucosyl-L-threonine at 290
O-glucosyl-L-serine at 893
O-fucosyl-L-serine at 863
O-glucosyl-L-serine at 626
O-fucosyl-L-serine at 1349
O-fucosyl-L-threonine (N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl group) at unknown position
O-fucosyl-L-threonine (alpha- N- acetylneuraminyl- (2?3)- beta- D- galactopyranosyl- (1?4)- 2- acetamido- 2- deoxy- ?- D- glucopyranosyl- (1?3)- 6- deoxy- alpha- L- galactopyranosyl group) at unknown position
O-fucosyl-L-threonine (beta- D- galactopyranosyl- (1?4)- 2- acetamido- 2- deoxy- beta- D- glucopyranosyl- (1?3)- 6- deoxy- alpha- L- galactopyranosyl group) at unknown position
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