instancebrowser | sectioned | sidebarwithdynamichierarchy
Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P27986
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Phosphatidylinositol 3-kinase regulatory subunit alpha shortName:PI3-kinase regulatory subunit alpha shortName:PI3K regulatory subunit alpha shortName:PtdIns-3-kinase regulatory subunit alpha alternativeName: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha shortName:PI3-kinase subunit p85-alpha shortName:PtdIns-3-kinase regulatory subunit p85-alpha
Links to corresponding entries in other databasesBioGPS Gene:5295
CTD Gene:5295
DOCK Blaster:1A0N
DOCK Blaster:1AZG
DOCK Blaster:1H9O
DOCK Blaster:1PBW
DOCK Blaster:1PHT
DOCK Blaster:1PIC
DOCK Blaster:1PKS
DOCK Blaster:1PKT
DOCK Blaster:2IUG
DOCK Blaster:2IUH
DOCK Blaster:2IUI
ENSEMBL:ENSG00000145675
GeneCards:P27986
HapMap:NM_181523
KEGG Gene:5295
NCBI Gene:5295
OMIM:171833
Orphanet:22044
PRO:P27986
Protein Data Bank:1A0N
Protein Data Bank:1AZG
Protein Data Bank:1H9O
Protein Data Bank:1PBW
Protein Data Bank:1PHT
Protein Data Bank:1PIC
Protein Data Bank:1PKS
Protein Data Bank:1PKT
Protein Data Bank:2IUG
Protein Data Bank:2IUH
Protein Data Bank:2IUI
RefSeq:NM_181523
RefSeq:NP_852664
UCSC human:P27986
UniProt:P27986
ZINC_target:P27986
dbSNP Gene:5295
Other identifiers related to this sequenceP85A_HUMAN, B3KT19, D3DWA0, E7EX19, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5, 212240_s_at, AAO15359, 11748670_a_at, 3HHM, 35373_at, PR00678, EntrezGene:5295, IPR008936, 212239_at, 11733019_a_at, 73148_at, JX133164, E5RJY0, 18387942, PF00620, BAG54309, EAW51313, PH_hs_0021977, 1PHT, 2813142, AFP86292, CH471137, 0000770592, IPR001452, NM_181523, AK126345, 212249_at, B3KWZ7, A_14_P105607, 2813153, MIM:615214, 1AZG, 2813150, 0004610204, 2813127, NP_852664, 2813158, Hs.6241.0.S2_3p_at, 2IUG, 2IUI, 4A55, ENSG00000145675, HPA001216, AK094785, Hs.6241.0.S1_3p_a_at, MIM:269880, 1PKT, 2813101, 2813152, 11754631_x_at, 2813132, 55623_at, IPR000198, HGNC:8979, EAW51312, J7GU64, GE85962, XP_005248599, AAB04140, 2813156, AAH94795, uc003jva.3, 2813145, ILMN_2398235, 2813092, ILMN_1760303, AFP86291, BAG52931, 2813102, 11733018_s_at, Hs.592983, AF279367, IPR000980, 2813103, 11739540_a_at, 1H9O, SM00324, IPR001720, 1PBW, Hs.6241.0.S3_3p_at, A_23_P144980, BC094795, M61906_at, 3I5S, 2813135, PIK3R1, AK223613, 2813125, E5RGI8, AC016564, 4L1B, 4L23, UPI000013D9FF, JX133165, PIK3R1-001, 2813134, NM_181504, SM00326, PR00401, U49349, ENSP00000428056, Hs.132225, 4JPS, 44015_at, Hs.604502, 11739541_a_at, CAB004268, 2813154, 2V1Y, SM00252, 8105778, IPR003191, M61906, 3HIZ, GE58013, PF00017, OTTHUMP00000161918, 1PIC, CCDS3993, 73150_g_at, BAD97333, 4L2Y, 16985518, 3I5R, 11733017_a_at, 1269_at, 2IUH, PF07653, A_24_P29401, BC030815, AAH30815, 2813146, 1PKS, J7GXU7, 77475_at, 2813157, MIM:171833, 1A0N, 5295, 1314371, XM_005248542, 2813155, 2RD0, 11739539_a_at, 2813091, IPR011511, AC104120, 2813148, ILMN_1689057, 2813159, E5RHI0, PIK3R1-016, ENSP00000429277, OTTHUMP00000226152, ILMN_1691433, 2813137, NP_852665, OTTHUMP00000161919, 0005050156, NM_181524, CCDS3994, uc003jvc.3, UPI00000743EC, ENSP00000323512, PIK3R1-002, GE88834, ILMN_2289433, NP_852556, OTTHUMP00000161920, ENSP00000338554, UPI000014094F, 0001190184, uc003jvd.3, CCDS3995, 2813140, PIK3R1-003, PIK3R1-004, 2813143, NM_001242466, UPI0000E5AC63, OTTHUMP00000226159, uc021xzn.1, CCDS56374, ENSP00000430098, NP_001229395
Molecules with this sequencePIK3R1 [cytosol] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 D560Y [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 N564D [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 N564K [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 D560H [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 R574I [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 R574T [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 R574_T576del [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 H450_E451del [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 Y463_L466del [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 K459del [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
PIK3R1 G376R [plasma membrane] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
K63polyUb-PIK3R1 [cytosol] UKENBCdOORHPGPPPPPPPPPPPURDDDDDDDDDDDZ
SH2 domain
Component ofEGF:p-6Y-EGFR:GRB2:GAB1:PIK3 [plasma membrane]
GRB2:GAB1:PIK3R1 [cytosol]
EGF:p-6Y-EGFR:GRB2:GAB1:PIK3R1 [plasma membrane]
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane]
PIK3CB:PIK3R1 [cytosol]
PIK3CD:PIK3R1 [cytosol]
PIK3CA:PIK3R1 [cytosol]
p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol]
p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol]
PIK3CD:PIK3R1 [plasma membrane]
...
List all 67 items
Represented by generalisation(s)PI3K-regulatory subunit [cytosol]
PI3K-regulatory subunits [cytosol]
PI3K-regulatory subunits [cytosol]
PIK3R1 iSH2 domain mutants [plasma membrane]
PIK3R1 nSH2 domain mutants [plasma membrane]
K63polyUb-PI3K-regulatory subunits [cytosol]
PIK3R1 mutants [plasma membrane]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

Hemostasis

Metabolism

Cell-Cell communication

Disease

Modifications in molecules with this sequenceL-asparagine 564 replaced with L-aspartic acid
L-asparagine 564 replaced with L-lysine
L-aspartic acid 560 replaced with L-histidine
L-aspartic acid 560 replaced with L-tyrosine
L-arginine 574 replaced with L-isoleucine
L-arginine 574 replaced with L-threonine
Deletion of residues 463 to 466
Deletion of residues 450 to 451
Deletion of residues 459 to 459
Deletion of residues 574 to 576
glycine 376 replaced with L-arginine
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
DomainsSH2 domain
[Change default viewing format]