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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P27986
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Phosphatidylinositol 3-kinase regulatory subunit alpha shortName:PI3-kinase regulatory subunit alpha shortName:PI3K regulatory subunit alpha shortName:PtdIns-3-kinase regulatory subunit alpha alternativeName: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha shortName:PI3-kinase subunit p85-alpha shortName:PtdIns-3-kinase regulatory subunit p85-alpha
Links to corresponding entries in other databasesBioGPS Gene:5295
CTD Gene:5295
DOCK Blaster:1A0N
DOCK Blaster:1AZG
DOCK Blaster:1H9O
DOCK Blaster:1PBW
DOCK Blaster:1PHT
DOCK Blaster:1PIC
DOCK Blaster:1PKS
DOCK Blaster:1PKT
DOCK Blaster:2IUG
DOCK Blaster:2IUH
DOCK Blaster:2IUI
ENSEMBL:ENSG00000145675
GeneCards:P27986
HapMap:NM_181523
KEGG Gene:5295
NCBI Gene:5295
OMIM:171833
Protein Data Bank:1A0N
Protein Data Bank:1AZG
Protein Data Bank:1H9O
Protein Data Bank:1PBW
Protein Data Bank:1PHT
Protein Data Bank:1PIC
Protein Data Bank:1PKS
Protein Data Bank:1PKT
Protein Data Bank:2IUG
Protein Data Bank:2IUH
Protein Data Bank:2IUI
RefSeq:NM_181523
RefSeq:NP_852664
UCSC human:P27986
UniProt:P27986
dbSNP Gene:5295
Other identifiers related to this sequenceP85A_HUMAN, B3KT19, D3DWA0, E7EX19, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5, ENSG00000145675, ENST00000274335, ENSP00000274335, 1269_at, 212239_at, 212249_at, 212240_s_at, 35373_at, 55623_at, 44015_at, 77475_at, M61906_at, Hs.6241.0.S3_3p_at, Hs.6241.0.S1_3p_a_at, Hs.6241.0.S2_3p_at, A_14_P105607, A_24_P937193, A_23_P144980, A_24_P29401, A_23_P144976, CCDS3993, CCDS3994, CCDS3995, GE58013, GE85962, M61906, U49349, AF279367, AK223613, BC030815, BC094795, EntrezGene:5295, GI_32455251-A, GI_32455247-I, ILMN_2592, ILMN_5923, IPI00807573, IPI00021448, IPI00333040, IPI00295788, MIM:171833, 1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, AAB04140, AAO15359, BAD97333, AAH30815, AAH94795, NM_181523, NM_181524, NM_181504, NP_852664, NP_852665, NP_852556, OTTHUMT00000254013, OTTHUMT00000254014, OTTHUMT00000254015, Hs.592983, Hs.132225, P27986, P85A_HUMAN, P27986-4, P27986-3, P27986-2, IPR000980, IPR001452, IPR001720, IPR000198, IPR011511
Molecules with this sequencePIK3R1 [cytosol] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 D560Y [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 N564D [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 N564K [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 D560H [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 R574I [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 R574T [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 R574_T576del [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 H450_E451del [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 Y463_L466del [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 K459del [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
PIK3R1 G376R [plasma membrane] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
K63polyUb-PIK3R1 [cytosol] UKENBCdORHGURPPPPPPPPPPPDDDDDDDDDDD
SH2 domain
Component ofEGF:p-6Y-EGFR:GRB2:GAB1:PIK3 [plasma membrane]
GRB2:GAB1:PIK3R1 [cytosol]
EGF:p-6Y-EGFR:GRB2:GAB1:PIK3R1 [plasma membrane]
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane]
PIK3CB:PIK3R1 [cytosol]
PIK3CD:PIK3R1 [cytosol]
PIK3CA:PIK3R1 [cytosol]
p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol]
p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol]
PIK3CD:PIK3R1 [plasma membrane]
...
List all 67 items
Represented by generalisation(s)PI3K-regulatory subunit [cytosol]
PI3K-regulatory subunits [cytosol]
PI3K-regulatory subunits [cytosol]
PIK3R1 iSH2 domain mutants [plasma membrane]
PIK3R1 nSH2 domain mutants [plasma membrane]
K63polyUb-PI3K-regulatory subunits [cytosol]
PIK3R1 mutants [plasma membrane]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

Hemostasis

Metabolism

Cell-Cell communication

Disease

Modifications in molecules with this sequenceL-asparagine 564 replaced with L-aspartic acid
L-asparagine 564 replaced with L-lysine
L-aspartic acid 560 replaced with L-histidine
L-aspartic acid 560 replaced with L-tyrosine
L-arginine 574 replaced with L-isoleucine
L-arginine 574 replaced with L-threonine
Deletion of residues 463 to 466
Deletion of residues 450 to 451
Deletion of residues 459 to 459
Deletion of residues 574 to 576
glycine 376 replaced with L-arginine
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
DomainsSH2 domain
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