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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:Q99814
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Endothelial PAS domain-containing protein 1 shortName:EPAS-1 alternativeName: Basic-helix-loop-helix-PAS protein MOP2 alternativeName: Class E basic helix-loop-helix protein 73 shortName:bHLHe73 alternativeName: HIF-1-alpha-like factor shortName:HLF alternativeName: Hypoxia-inducible factor 2-alpha shortName:HIF-2-alpha shortName:HIF2-alpha alternativeName: Member of PAS protein 2 alternativeName: PAS domain-containing protein 2
Links to corresponding entries in other databasesBioGPS Gene:2034
CTD Gene:2034
DOCK Blaster:1P97
ENSEMBL:ENSG00000116016
GeneCards:Q99814
HapMap:NM_001430
KEGG Gene:2034
NCBI Gene:2034
OMIM:603349
Orphanet:18353
PRO:Q99814
Protein Data Bank:1P97
RefSeq:NM_001430
RefSeq:NP_001421
UCSC human:Q99814
UniProt:Q99814
ZINC_target:Q99814
dbSNP Gene:2034
Other identifiers related to this sequenceEPAS1_HUMAN, Q86VA2, Q99630, 2480386, 2480392, 200879_s_at, SM00091, PF00989, 2034, ENSG00000116016, SM00086, AK123845, 2480455, 2480434, PR00785, U51626, 2480387, 2480441, 2480448, Hs.468410, SM00353, IPR013767, 3F1P, CAB012248, BC051338, g4503576_3p_a_at, 2480454, OTTHUMP00000159033, 0004480603, 2480420, A_23_P430120, EPAS1-001, AAY14704, EPAS1, MIM:603349, 2480444, 18378852, AC016912, HGNC:3374, 3F1O, 2480391, IPR014887, ILMN_1704753, C9J9N2, B3KW07, IPR021537, IPR001610, Hs.612254, 2480447, NM_001430, UPI000013D44F, 200878_at, PH_hs_0021983, AAC51212, ENSP00000263734, 2480388, 4GS9, 3H7W, BAG53969, 38230_at, U81984_at, 4GHI, AAB41495, IPR013655, 2A24, U81984, 2480453, 2480443, 11715411_a_at, A_23_P210210, PF08778, 2480421, NP_001421, IPR000014, 2480389, 2480456, 3H82, 0104730576, EntrezGene:2034, PH_hs_0048613, GE59478, 8041781, 16879721, 2480433, AAH51338, uc002ruv.3, 1P97, MIM:611783, 9000051, 9079689, GE85977, 2480424, PF11413, 2480449, PF08447, CCDS1825, Hs.8136.0.S2_3p_at, AC016696, 2480432, 2480440, 11715412_a_at, 2480390, ILMN_1760034, IPR001067, IPR011598, Q53SM6, 2480425, Hs.712799, 2480451, 3F1N
Molecules with this sequenceEPAS1 [nucleoplasm] UKENBCdOORHPGPURDZ
HN-EPAS1 [cytosol] UKENBCdOORHPGPURDZ
EPAS1 [cytosol] UKENBCdOORHPGPURDZ
2xHP-EPAS1 [cytosol] UKENBCdOORHPGPURDZ
2xHP-EPAS1 [nucleoplasm] UKENBCdOORHPGPURDZ
Component ofHIF [nucleoplasm]
HIF:CBP:p300 [nucleoplasm]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm]
ub-HIF-alpha [nucleoplasm]
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm]
ub-hydroxyPro-HIF-alpha [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [cytosol]
Represented by generalisation(s)HIF-alpha [nucleoplasm]
hydroxyAsn-HIF1A,HIF2A [cytosol]
HIF1A,HIF2A [cytosol]
HIF-alpha [cytosol]
hydroxyPro-HIF-alpha [cytosol]
hydroxyPro-HIF-alpha [nucleoplasm]
Processes where molecules and complexes with this sequence are involved

Developmental Biology

Cellular responses to stress

Modifications in molecules with this sequencemonohydroxylated asparagine at 847
monohydroxylated proline at 531
monohydroxylated proline at 405
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