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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:62251
_displayNameUniProt:P07225 PROS1
_timestamp2014-11-19 11:06:05
checksum2B88A04F85403F25
commentFUNCTION Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.TISSUE SPECIFICITY Plasma.
crossReference[DatabaseIdentifier:6566550] PRO:P07225
[DatabaseIdentifier:6610517] GeneCards:P07225
[DatabaseIdentifier:6621213] Protein Data Bank:1Z6C
[DatabaseIdentifier:6635060] UCSC human:P07225
[DatabaseIdentifier:6650116] RefSeq:NP_000304
[DatabaseIdentifier:6704540] DOCK Blaster:1Z6C
[DatabaseIdentifier:6716741] HMDB_protein:HMDBP02003
descriptionrecommendedName: Vitamin K-dependent protein S
geneNamePROS1
PROS
identifierP07225
isSequenceChangedFALSE
keyword3D-structure
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Disulfide bond
EGF-like domain
Fibrinolysis
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Thrombophilia
Zymogen
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:6348073] Croft, D
[InstanceEdit:6378953] Croft, D
[InstanceEdit:6410971] Croft, D
[InstanceEdit:6442989] Croft, D
[InstanceEdit:6475007] Croft, D
[InstanceEdit:6507025] Croft, D
[InstanceEdit:6609128] Croft, D
[InstanceEdit:6616891] Croft, D
[InstanceEdit:6626660] Croft, D
[InstanceEdit:6633671] Croft, D
[InstanceEdit:6641434] Croft, D
[InstanceEdit:6672501] Croft, D
[InstanceEdit:6688369] Croft, D
[InstanceEdit:6700780] Croft, D
[InstanceEdit:6715121] Croft, D
namePROS1
otherIdentifier0005550497
11720133_a_at
11720134_s_at
11720135_a_at
17123302
17123306
17123308
17123310
1Z6C
207808_s_at
2685269
2685271
2685273
2685275
2685277
2685278
2685293
2685295
2685305
2685306
2685307
2685308
2685309
2685310
2685311
2685315
2685319
2685322
2685323
2685328
2685337
2685338
2685339
35752_s_at
5627
8089015
A_23_P73114
A_24_P383480
AB083386
AB083387
AB083389
AC117474
AC144562
AH002948
AK292994
AK303895
AY308744
AY605182
B4E1L6
BC015801
C9K0R0
CCDS2923
CH471052
DQ902689
ENSG00000184500
ENSP00000377783
ENST00000394236
EntrezGene:5627
g4506116_3p_a_at
G5E9F8
GE57827
HGNC:9456
HPA007724
HPA023974
Hs.592946
Hs.64016
ILMN_1671928
IPR000294
IPR000742
IPR001791
IPR001881
IPR008985
M14338_at
M15036
M57840
M57841
M57842
M57844
M57845
M57846
M57847
M57848
M57849
M57850
M57851
M57852
M57853
MIM:176880
MIM:612336
MIM:614514
NM_000313
NP_000304
OTTHUMP00000197145
PF00008
PF00054
PF00594
PF02210
PF07645
PH_hs_0003988
PR00001
PROS1
PROS1-001
Q06F35
Q6J1N0
Q8IXD2
Q8IXD4
Q8IXD5
SM00069
SM00179
SM00181
SM00282
TC03001590.hg
TC03002992.hg
TC03002994.hg
uc003drb.4
UPI00001323E8
XP_005247683
Y00692
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6690418] KEGG Gene:5627 protein S (alpha) [Homo sapiens]
[ReferenceDNASequence:6356310] ENSEMBL:ENSG00000184500 [Homo sapiens]
[ReferenceDNASequence:6387201] NCBI Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6414937] BioGPS Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6446955] CTD Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6478973] dbSNP Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6632876] OMIM:176880 [Homo sapiens]
[ReferenceDNASequence:6699302] Orphanet:15148 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6686529] RefSeq:NM_000313
secondaryIdentifierPROS_HUMAN
A8KAC9
D3DN28
Q15518
Q7Z715
Q9UCZ8
sequenceLength676
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:141004] 11xCbxE-PROS1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159758] PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159770] 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159792] PROS1(25-41) [Golgi lumen] [Homo sapiens]
[EntityWithAccessionedSequence:159850] 11xCbxE-PROS1(25-676) [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159865] 11xCbxE-PROS1 [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:202772] 11xCbxE-PROS1 [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:349762] 11xCbxE-PROS1 [platelet alpha granule lumen] [Homo sapiens]
(referenceSequence)[ModifiedResidue:140994] L-gamma-carboxyglutamic acid at 77
[ModifiedResidue:140995] L-gamma-carboxyglutamic acid at 73
[ModifiedResidue:140996] L-gamma-carboxyglutamic acid at 70
[ModifiedResidue:140997] L-gamma-carboxyglutamic acid at 67
[ModifiedResidue:140998] L-gamma-carboxyglutamic acid at 66
[ModifiedResidue:140999] L-gamma-carboxyglutamic acid at 61
[ModifiedResidue:141000] L-gamma-carboxyglutamic acid at 60
[ModifiedResidue:141001] L-gamma-carboxyglutamic acid at 57
[ModifiedResidue:141002] L-gamma-carboxyglutamic acid at 55
[ModifiedResidue:141003] L-gamma-carboxyglutamic acid at 48
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