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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:62251
_displayNameUniProt:P07225 PROS1
_timestamp2014-05-28 17:17:54
checksum2B88A04F85403F25
commentFUNCTION Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.TISSUE SPECIFICITY Plasma.SIMILARITY Contains 4 EGF-like domains.SIMILARITY Contains 1 Gla (gamma-carboxy-glutamate) domain.SIMILARITY Contains 2 laminin G-like domains.
crossReference[DatabaseIdentifier:6441474] GeneCards:P07225
[DatabaseIdentifier:6455787] UCSC human:P07225
[DatabaseIdentifier:6470323] RefSeq:NP_000304
[DatabaseIdentifier:6522771] Protein Data Bank:1Z6C
[DatabaseIdentifier:6531828] DOCK Blaster:1Z6C
descriptionrecommendedName: Vitamin K-dependent protein S
geneNamePROS1
PROS
identifierP07225
isSequenceChangedFALSE
keyword3D-structure
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Disulfide bond
EGF-like domain
Fibrinolysis
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Thrombophilia
Zymogen
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:6281038] Croft, D
[InstanceEdit:6311957] Croft, D
[InstanceEdit:6343996] Croft, D
[InstanceEdit:6376035] Croft, D
[InstanceEdit:6408074] Croft, D
[InstanceEdit:6440113] Croft, D
[InstanceEdit:6447579] Croft, D
[InstanceEdit:6454426] Croft, D
[InstanceEdit:6461892] Croft, D
[InstanceEdit:6492909] Croft, D
[InstanceEdit:6508136] Croft, D
[InstanceEdit:6518483] Croft, D
[InstanceEdit:6528104] Croft, D
namePROS1
otherIdentifierENSG00000184500
ENST00000394236
ENSP00000377783
ENST00000348974
ENSP00000330021
207808_s_at
35752_s_at
M14338_at
g4506116_3p_a_at
A_24_P119141
A_23_P73114
A_24_P383480
A_23_P84510
A_32_P500684
CCDS2923
GE57827
AB083387
DQ453484
S81775
AB083394
DQ902689
AB087994
DQ453481
AY605182
AB084901
AB083687
AB084903
X12892
DQ453483
AB084902
AB083389
AB083388
AB083386
AB083688
S81777
AB084900
AB083393
AB083391
AB083390
M14338
M15036
Y00692
M57853
M57840
M57841
M57842
M57844
M57845
M57846
M57847
M57848
M57849
M57850
M57851
M57852
M36564
M36551
M36552
M36553
M36554
M36555
M36556
M36557
M36558
M36559
M36560
M36561
M36563
AY308744
BC015801
EntrezGene:5627
GI_4506116-S
ILMN_3398
IPI00294004
IPI00385739
IPI00413699
IPI00795619
IPI00854618
IPI00854718
IPI00854739
IPI00854866
MIM:176880
1Z6C
BAC54135
ABD96175
AAD14374
BAC54142
ABI93127
BAC55115
ABD96173
AAT37717
BAC54254
BAC21163
BAC54256
CAA31383
ABD96174
BAC54255
BAC54137
BAC54136
BAC54134
BAC21164
AAD14375
BAC54253
BAC54141
BAC54139
BAC54138
AAA60181
AAA36479
CAA68687
CAA68688
AAA60357
AAA60180
AAP45054
AAH15801
NM_000313
NP_000304
Hs.64016
Hs.592946
Q8IXD4
Q1W146
Q7KYZ1
Q8IXC8
Q06F35
Q86Z10
Q1W148
Q6J1N0
Q8IXC5
Q8J011
Q8IXC3
Q9NSD0
Q1W147
Q8IXC4
Q8IXD2
Q8IXD3
Q8IXD5
Q8J010
Q16441
Q8IXC6
Q8IXC9
Q8IXD0
Q8IXD1
Q16519
P07225
Q8IXD4_HUMAN
Q1W146_HUMAN
Q7KYZ1_HUMAN
Q8IXC8_HUMAN
Q06F35_HUMAN
Q86Z10_HUMAN
Q1W148_HUMAN
Q6J1N0_HUMAN
Q8IXC5_HUMAN
Q8J011_HUMAN
Q8IXC3_HUMAN
Q9NSD0_HUMAN
Q1W147_HUMAN
Q8IXC4_HUMAN
Q8IXD2_HUMAN
Q8IXD3_HUMAN
Q8IXD5_HUMAN
Q8J010_HUMAN
Q16441_HUMAN
Q8IXC6_HUMAN
Q8IXC9_HUMAN
Q8IXD0_HUMAN
Q8IXD1_HUMAN
Q16519_HUMAN
PROS_HUMAN
IPR000152
IPR000294
IPR001881
IPR013032
IPR002383
IPR006209
IPR012679
IPR012680
IPR013091
IPR000742
IPR001791
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6510151] KEGG Gene:5627 protein S (alpha) [Homo sapiens]
[ReferenceDNASequence:6289172] ENSEMBL:ENSG00000184500 [Homo sapiens]
[ReferenceDNASequence:6320082] NCBI Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6347988] BioGPS Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6380027] CTD Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6412066] dbSNP Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6453650] OMIM:176880 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6506370] RefSeq:NM_000313
secondaryIdentifierPROS_HUMAN
A8KAC9
D3DN28
Q15518
Q7Z715
Q9UCZ8
sequenceLength676
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:141004] 11xCbxE-PROS1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159758] PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159770] 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159792] PROS1(25-41) [Golgi lumen] [Homo sapiens]
[EntityWithAccessionedSequence:159850] 11xCbxE-PROS1(25-676) [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159865] 11xCbxE-PROS1 [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:202772] 11xCbxE-PROS1 [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:349762] 11xCbxE-PROS1 [platelet alpha granule lumen] [Homo sapiens]
(referenceSequence)[ModifiedResidue:140994] L-gamma-carboxyglutamic acid at 77
[ModifiedResidue:140995] L-gamma-carboxyglutamic acid at 73
[ModifiedResidue:140996] L-gamma-carboxyglutamic acid at 70
[ModifiedResidue:140997] L-gamma-carboxyglutamic acid at 67
[ModifiedResidue:140998] L-gamma-carboxyglutamic acid at 66
[ModifiedResidue:140999] L-gamma-carboxyglutamic acid at 61
[ModifiedResidue:141000] L-gamma-carboxyglutamic acid at 60
[ModifiedResidue:141001] L-gamma-carboxyglutamic acid at 57
[ModifiedResidue:141002] L-gamma-carboxyglutamic acid at 55
[ModifiedResidue:141003] L-gamma-carboxyglutamic acid at 48
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