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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:62251
_displayNameUniProt:P07225 PROS1
_timestamp2014-09-11 06:48:34
checksum2B88A04F85403F25
commentFUNCTION Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.TISSUE SPECIFICITY Plasma.SIMILARITY Contains 4 EGF-like domains.SIMILARITY Contains 1 Gla (gamma-carboxy-glutamate) domain.SIMILARITY Contains 2 laminin G-like domains.
crossReference[DatabaseIdentifier:6575418] PRO:P07225
[DatabaseIdentifier:6620324] GeneCards:P07225
[DatabaseIdentifier:6630857] Protein Data Bank:1Z6C
[DatabaseIdentifier:6644512] UCSC human:P07225
[DatabaseIdentifier:6659312] RefSeq:NP_000304
[DatabaseIdentifier:6715044] DOCK Blaster:1Z6C
descriptionrecommendedName: Vitamin K-dependent protein S
geneNamePROS1
PROS
identifierP07225
isSequenceChangedFALSE
keyword3D-structure
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Disulfide bond
EGF-like domain
Fibrinolysis
Gamma-carboxyglutamic acid
Glycoprotein
Hemostasis
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Thrombophilia
Zymogen
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:6348050] Croft, D
[InstanceEdit:6379983] Croft, D
[InstanceEdit:6413044] Croft, D
[InstanceEdit:6446105] Croft, D
[InstanceEdit:6479166] Croft, D
[InstanceEdit:6512227] Croft, D
[InstanceEdit:6618954] Croft, D
[InstanceEdit:6626557] Croft, D
[InstanceEdit:6636231] Croft, D
[InstanceEdit:6643142] Croft, D
[InstanceEdit:6650745] Croft, D
[InstanceEdit:6682804] Croft, D
[InstanceEdit:6698332] Croft, D
[InstanceEdit:6711320] Croft, D
namePROS1
otherIdentifierCAA68688
2685308
M57853
AC117474
2685310
AK292994
XP_005247683
2685316
C9K0R0
IPR001881
ILMN_1671928
2685269
35752_s_at
CH471052
2685291
Q8IXD4
A_23_P73114
M57851
AK303895
Y00692
IPR001791
2685321
A_24_P383480
2685278
PROS1-001
M57847
NP_000304
IPR000294
NM_000313
HPA023974
Q06F35
2685273
2685339
PROS1
11720133_a_at
AAA60180
PF07645
2685277
2685324
PR00001
1Z6C
B4E1L6
1833851
BAC54134
OTTHUMP00000197145
EAW79904
8089011
11720134_s_at
17123310
ENSP00000377783
M57841
BAC54137
EntrezGene:5627
Hs.64016
uc003drb.4
2685338
2685305
M57850
HGNC:9456
8089015
M57845
HPA007724
UPI00001323E8
BC015801
M57849
AAT37717
MIM:176880
2685275
ENSG00000184500
Q6J1N0
AAA60357
0005550497
2685293
2685307
AC144562
Q8IXD2
2685295
2685287
2685315
Q8IXD5
2685280
2685313
EAW79903
PF00054
17123302
SM00282
2685322
5627
2685282
2685328
SM00179
214811
AH002948
MIM:612336
2685311
CCDS2923
17123308
PF00008
AB083389
2685309
ABI93127
PF02210
AB083387
AY605182
2685319
M15036
MIM:614514
2685317
M14338_at
CAA68687
M57846
AAA36479
DQ902689
AAH15801
BAF85683
BAC54135
2685306
M57842
AB083386
AY308744
17123306
2685271
M57844
AAP45054
16956569
2685323
PF00594
M57840
Hs.592946
SM00069
IPR008985
207808_s_at
PH_hs_0003988
SM00181
g4506116_3p_a_at
GE57827
2685314
IPR000742
EAW79905
11720135_a_at
M57848
G5E9F8
2685337
M57852
BAG64828
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6700364] KEGG Gene:5627 protein S (alpha) [Homo sapiens]
[ReferenceDNASequence:6356301] ENSEMBL:ENSG00000184500 [Homo sapiens]
[ReferenceDNASequence:6388232] NCBI Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6417140] BioGPS Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6450201] CTD Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6483262] dbSNP Gene:5627 [Homo sapiens]
[ReferenceDNASequence:6642356] OMIM:176880 [Homo sapiens]
[ReferenceDNASequence:6721856] Orphanet:15148 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6696530] RefSeq:NM_000313
secondaryIdentifierPROS_HUMAN
A8KAC9
D3DN28
Q15518
Q7Z715
Q9UCZ8
sequenceLength676
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:141004] 11xCbxE-PROS1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159758] PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159770] 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159792] PROS1(25-41) [Golgi lumen] [Homo sapiens]
[EntityWithAccessionedSequence:159850] 11xCbxE-PROS1(25-676) [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:159865] 11xCbxE-PROS1 [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:202772] 11xCbxE-PROS1 [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:349762] 11xCbxE-PROS1 [platelet alpha granule lumen] [Homo sapiens]
(referenceSequence)[ModifiedResidue:140994] L-gamma-carboxyglutamic acid at 77
[ModifiedResidue:140995] L-gamma-carboxyglutamic acid at 73
[ModifiedResidue:140996] L-gamma-carboxyglutamic acid at 70
[ModifiedResidue:140997] L-gamma-carboxyglutamic acid at 67
[ModifiedResidue:140998] L-gamma-carboxyglutamic acid at 66
[ModifiedResidue:140999] L-gamma-carboxyglutamic acid at 61
[ModifiedResidue:141000] L-gamma-carboxyglutamic acid at 60
[ModifiedResidue:141001] L-gamma-carboxyglutamic acid at 57
[ModifiedResidue:141002] L-gamma-carboxyglutamic acid at 55
[ModifiedResidue:141003] L-gamma-carboxyglutamic acid at 48
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