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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P60484
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ecNumber3.1.3.16/ecNumber ecNumber3.1.3.48/ecNumber ecNumber3.1.3.67/ecNumber alternativeName: Mutated in multiple advanced cancers 1 alternativeName: Phosphatase and tensin homolog
Links to corresponding entries in other databasesBioGPS Gene:5728
BioGPS Gene:731292
Brenda:3.1.3.16
Brenda:3.1.3.48
Brenda:3.1.3.67
CTD Gene:5728
CTD Gene:731292
DOCK Blaster:1D5R
EC:3.1.3.16
EC:3.1.3.48
EC:3.1.3.67
ENSEMBL:ENSG00000171862
GeneCards:P60484
HapMap:NM_000314
IntEnz:3.1.3.16
IntEnz:3.1.3.48
IntEnz:3.1.3.67
KEGG Gene:5728
NCBI Gene:5728
NCBI Gene:731292
OMIM:137800
OMIM:153480
OMIM:158350
OMIM:176807
OMIM:176920
OMIM:275355
OMIM:276950
OMIM:601728
OMIM:605309
OMIM:608089
Orphanet:15166
PRO:P60484
Protein Data Bank:1D5R
RefSeq:NM_000314
RefSeq:NP_000305
UCSC human:P60484
UniProt:P60484
dbSNP Gene:5728
dbSNP Gene:731292
Other identifiers related to this sequencePTEN_HUMAN, B2R904, O00633, O02679, Q6ICT7, 3256779, JQ037773, AF143312, 3256708, AF000734, 3256767, ENSP00000361021, GE480829, 3256772, 3256705, 3256711, AF143314, A_24_P252785, 3256725, 3203667, 3256701, EntrezGene:5728, H6WA51, EAW50174, PTEN-001, HM849630, 3256698, Hs.600528, ADM26753, 90129_at, AAH05821, 11757445_s_at, 3256780, BAG36351, U96180, AAD38372, AF000732, Hs.27865.0.S1_3p_at, PTEN, F6KD01, ENST00000371953, MIM:601728, 3256740, JQ037771, 3203673, ADM26756, UPI00001328C5, 3256703, OTTHUMP00000020032, IPR000008, JQ037770, GE88557, 3256736, NM_000314, IPR029023, Hs.717458, 3256697, 204053_x_at, 3256738, AEZ67437, AEZ67430, 3256764, 56027_at, PF10409, AAC51183, JQ037778, JQ037777, AF000731, 217492_s_at, 3256777, AHW56562, ADM26755, 3256784, 225363_at, 3256710, Hs.706095, 3203671, 11758421_s_at, DQ073384, 1434_at, 3256782, 3256773, Hs.660035, AK313581, AF000728, SM00404, 9090379, 1D5R, AF143315, 11719324_x_at, 3256790, CR450306, HM849629, 204054_at, 3256707, MIM:137800, AAY57327, HPA031335, H6WA46, 39552_at, IPR000340, 8160718, 58901_at, AEZ67435, AF000730, 3256700, AEZ67429, AAC51182, 11719323_at, IPR003595, JQ037769, AF000726, AEZ67438, Hs.681727, uc001kfb.3, PF00102, 0000840347, 3256709, AF067844, ILMN_1880406, IPR017361, 3256702, 3203672, AAD13528, AEZ67433, AEZ67436, 228006_at, 211711_s_at, JQ037772, HM849631, JQ037774, A_24_P913115, 3256706, ADM26759, U92436_at, MIM:612242, NP_000305, IPR029021, IPR000242, MIM:176807, HGNC:9588, PH_hs_0047382, 3256704, 64073_at, AAB66902, MIM:153480, IPR000387, MIM:608089, GE59570, g13543309_3p_s_at, BC005821, JQ037775, XP_006717989, MIM:605309, 31675_s_at, MIM:276950, HM849634, ENSG00000171862, KJ534922, CCDS31238, LRG_311t1, 3203670, MIM:158350, MIM:613028, Hs.500466, Hs.98267.0.A1_3p_at, 3727827, ADM26754, CAG29302, Hs.644684, MIM:275355, ILMN_1701134, CAB004076, 5728, ILMN_1869718, g4506248_3p_at, 3203674, A_23_P98085, CH471066, AEZ67434, AAC08699, U92436, PF00782, LRG_311, 2KYL, AF143313, HM849628, 7928959, 3256785, U93051, 3256778, Hs.606086, AEZ67432, Hs.278506.0.S1_3p_s_at, 3256781, 3256699, AF000733, AF000729, AF000727, Hs.705847, 3256783, IPR014020, 3256739
Molecules with this sequencePTEN [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R130G [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN C124S [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R130Q [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R130L [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R130P [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN C124R [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN C124F [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN C124Y [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R173H [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R173C [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R173P [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN S170N [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN S170R [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN S170I [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN S170G [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN H123Y [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN G129R [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN G129V [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN G129E [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN H93Y [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN H93R [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN H93A [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN H93D [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN H93Q [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R335* [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R130* [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
PTEN R233* [cytosol] UKENNBBCCddOOOOOOOOOOORHPGPURD
Component ofPTEN:Mg2+ [cytosol]
Represented by generalisation(s)PTEN Phosphatase Domain Missense Mutants [cytosol]
PTEN Truncation Mutants [cytosol]
PTEN Mutants [cytosol]
Processes where molecules and complexes with this sequence are involved

Immune System

Signal Transduction

Metabolism

Disease

Modifications in molecules with this sequenceL-arginine 130 replaced with glycine
L-cysteine 124 replaced with L-serine
L-arginine 130 replaced with L-glutamine
L-arginine 130 replaced with L-leucine
L-arginine 130 replaced with L-proline
L-cysteine 124 replaced with L-arginine
L-cysteine 124 replaced with L-phenylalanine
L-cysteine 124 replaced with L-tyrosine
L-arginine 173 replaced with L-histidine
L-arginine 173 replaced with L-proline
L-arginine 173 replaced with L-cysteine
L-serine 170 replaced with L-asparagine
L-serine 170 replaced with L-arginine
L-serine 170 replaced with L-isoleucine
L-serine 170 replaced with glycine
L-histidine 123 replaced with L-tyrosine
glycine 129 replaced with L-glutamic acid
glycine 129 replaced with L-arginine
glycine 129 replaced with L-valine
L-histidine 93 replaced with L-tyrosine
L-histidine 93 replaced with L-arginine
L-histidine 93 replaced with L-alanine
L-histidine 93 replaced with L-glutamine
L-histidine 93 replaced with L-aspartic acid
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