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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:Q06124
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein phosphatase non-receptor type 11 ecNumber3.1.3.48/ecNumber alternativeName: Protein-tyrosine phosphatase 1D shortName:PTP-1D alternativeName: Protein-tyrosine phosphatase 2C shortName:PTP-2C alternativeName: SH-PTP2 shortName:SHP-2 shortName:Shp2 alternativeName: SH-PTP3
Links to corresponding entries in other databasesBrenda:3.1.3.48
DOCK Blaster:2SHP
EC:3.1.3.48
ENSEMBL:ENSG00000179295
GeneCards:Q06124
IntEnz:3.1.3.48
KEGG Gene:5781
OMIM:151100
OMIM:163950
OMIM:163955
OMIM:176876
OMIM:607785
Orphanet:15170
PRO:Q06124
Protein Data Bank:2SHP
UCSC human:Q06124
UniProt:Q06124
Other identifiers related to this sequencePTN11_HUMAN, A8K1D9, Q96HD7, 1280823, NP_542168, MIM:607785, 4H1O, 4H34, ACE60554, Hs.627572, SM00194, PF00102, PR00700, 4JE4, uc001ttw.1, 1552637_at, 3432351, 2851175, L08807, EntrezGene:5781, NM_080601, 3432352, ACE60555, MIM:163950, 11761200_at, A_23_P105436, 3432358, Hs.506852, BAA02740, IPR029021, 3ZM1, PR00401, IPR000242, 3432357, MIM:151100, 3432345, 4JMG, CCDS58280, L03535, 3136745, 2687517, SM00252, 3ZM2, EU779707, PTPN11, 7894486, 4DGP, PF00017, 3432343, 4DGX, Hs.682780, 3TL0, PTPN11-002, CH471054, GE79583, 3432344, BT007106, EAW98012, 3432340, AAP35770, 3MOW, B3GUD3, MIM:156250, AAA36611, 3O5X, Hs2.22868.1.S1_3p_at, ENSP00000376376, UPI000006F711, 3TKZ, EU779706, 3432334, 3432354, 5781, 4GWF, 3432353, LRG_614, AAH08692, X70766, BAF82543, 2SHP, D13540, 3ZM0, L07527, 7958846, OTTHUMP00000166108, 4JEG, CAB005377, BC008692, 3432342, 3ZM3, HGNC:9644, 3432350, 3B7O, 2775657, CAA50045, IPR000980, AAA17022, 16757255, MIM:176876, B3GUD4, ENSG00000179295, AK289854, XM_006719526, 3432359, LRG_614t1, 11729207_s_at, 11729206_at, 205867_at, 3432371, XP_006719589, 3136729, CCDS9163, U79291_at, ENSP00000340944, PTPN11-001, 3432374, 3432376, 0000940170, 1870_at, D13540_at, A_14_P201950, 3432373, PH_hs_0027176, 3432368, 2687514, SM00404, 2851168, 2775656, IPR003595, g292406_3p_a_at, UPI000013296E, 212610_at, 205868_s_at, 1871_g_at, GE613892, OTTHUMP00000166107, 38443_at, 3432367, 3432360, IPR000387, GE59447, A_23_P99027, 209895_at, 209896_s_at, NM_002834, 3432365, ILMN_1778236, uc001ttx.3, 3432372, g13430845_3p_at, 11729208_x_at, 3432369, g7770146_RC_3p_at, NP_002825, 3432375, ENST00000351677, A_32_P61757, A_23_P204090, 3432370, Hs.83572.0.S1_3p_at, IPR012152
Molecules with this sequencePTPN11 [cytosol] UKEOOOOOOPGPUD
p-Y546,Y584-PTPN11 [cytosol] UKEOOOOOOPGPUD
p-Y546-PTPN11 [cytosol] UKEOOOOOOPGPUD
Component ofEGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane]
pTie2 and SHP2 complex [plasma membrane]
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane]
PECAM-1:SHP-2 complex [plasma membrane]
pCTLA-4:Src kinases:SHP2 [plasma membrane]
Netrin1:pUnc5C:DCC:Shp2 [plasma membrane]
SHP2:GRB2 [cytosol]
...
List all 37 items
Represented by generalisation(s)SHP-2/SHP-1 [cytosol]
PTPs-SHP1/2/PTP1B [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Immune System

Hemostasis

Developmental Biology

Cell-Cell communication

Disease

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 546
O4'-phospho-L-tyrosine at 584
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