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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:Q06124
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein phosphatase non-receptor type 11 ecNumber3.1.3.48/ecNumber alternativeName: Protein-tyrosine phosphatase 1D shortName:PTP-1D alternativeName: Protein-tyrosine phosphatase 2C shortName:PTP-2C alternativeName: SH-PTP2 shortName:SHP-2 shortName:Shp2 alternativeName: SH-PTP3
Links to corresponding entries in other databasesBrenda:3.1.3.48
DOCK Blaster:2SHP
EC:3.1.3.48
ENSEMBL:ENSG00000179295
GeneCards:Q06124
IntEnz:3.1.3.48
KEGG Gene:5781
OMIM:151100
OMIM:163950
OMIM:163955
OMIM:176876
OMIM:607785
Protein Data Bank:2SHP
UCSC human:Q06124
UniProt:Q06124
Other identifiers related to this sequencePTN11_HUMAN, A8K1D9, Q96HD7, ENSG00000179295, ENST00000392596, ENSP00000376375, 1870_at, 1871_g_at, 205868_s_at, 209896_s_at, 212610_at, 209895_at, 205867_at, 1552637_at, 38443_at, D13540_at, U79291_at, Hs.83572.0.S1_3p_at, g7770146_RC_3p_at, g292406_3p_a_at, g13430845_3p_at, Hs2.22868.1.S1_3p_at, A_14_P201950, A_24_P84719, A_23_P99027, A_23_P204090, A_32_P61757, A_23_P105436, A_23_P204099, A_32_P191311, CCDS9163, GE59447, GE79583, S78088, D13540, L03535, L07527, L08807, X70766, BT007106, BC008692, EntrezGene:5781, EntrezGene:391771, EntrezGene:647552, GI_33356176-S, ILMN_45333, ILMN_17352, IPI00298347, IPI00735912, IPI00738138, IPI00658002, IPI00658023, MIM:176876, MIM:151100, MIM:163950, MIM:163955, MIM:607785, OTTHUMP00000166108, OTTHUMT00000259497, 2SHP, AAB21148, BAA02740, AAA36611, AAA17022, CAA50045, AAP35770, AAH08692, NM_002834, XR_016870, XM_929316, XR_016390, XM_936607, XR_018560, XR_015385, NP_002825, XP_934409, XP_941700, OTTHUMT00000259496, Hs.506852, Hs.592754, Hs.627572, Hs.647941, Hs.647972, Hs.653372, Hs.682780, Q16344, Q06124, Q16344_HUMAN, PTN11_HUMAN, Q06124-2, Q06124-3, IPR000387, IPR000242, IPR000980
Molecules with this sequencePTPN11 [cytosol] UKEOOOOOGUPD
p-Y546,Y584-PTPN11 [cytosol] UKEOOOOOGUPD
p-Y546-PTPN11 [cytosol] UKEOOOOOGUPD
Component ofEGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane]
pTie2 and SHP2 complex [plasma membrane]
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane]
PECAM-1:SHP-2 complex [plasma membrane]
pCTLA-4:Src kinases:SHP2 [plasma membrane]
Netrin1:pUnc5C:DCC:Shp2 [plasma membrane]
SHP2:GRB2 [cytosol]
...
List all 37 items
Represented by generalisation(s)SHP-2/SHP-1 [cytosol]
PTPs-SHP1/2/PTP1B [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Immune System

Hemostasis

Developmental Biology

Cell-Cell communication

Disease

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 546
O4'-phospho-L-tyrosine at 584
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