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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P84022
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Mothers against decapentaplegic homolog 3 shortName:MAD homolog 3 shortName:Mad3 shortName:Mothers against DPP homolog 3 shortName:hMAD-3 alternativeName: JV15-2 alternativeName: SMAD family member 3 shortName:SMAD 3 shortName:Smad3 shortName:hSMAD3
Links to corresponding entries in other databasesBioGPS Gene:4088
CTD Gene:4088
DOCK Blaster:1MHD
DOCK Blaster:1MJS
DOCK Blaster:1MK2
DOCK Blaster:1OZJ
DOCK Blaster:1U7F
ENSEMBL:ENSG00000166949
GeneCards:P84022
HapMap:NM_005902
KEGG Gene:4088
NCBI Gene:4088
OMIM:603109
Orphanet:19833
PRO:P84022
Protein Data Bank:1MHD
Protein Data Bank:1MJS
Protein Data Bank:1MK2
Protein Data Bank:1OZJ
Protein Data Bank:1U7F
RefSeq:NM_005902
RefSeq:NP_005893
UCSC human:P84022
UniProt:P84022
dbSNP Gene:4088
Other identifiers related to this sequenceSMAD3_HUMAN, A8K4B6, B7Z4Z5, B7Z6M9, B7Z9Q2, F5H383, O09064, O09144, O14510, O35273, Q92940, Q93002, Q9GKR4, 1OZJ, 3599041, IPR008984, 205398_s_at, 2LB2, 3599016, Q68DS8, 65983_at, AF025298, 1MJS, Hs.36915, 1MK2, AF025293, 3598999, 3599039, GE79350, 3598997, IPR013019, 3599032, H3BP09, U76622, 205397_x_at, uc002aqj.3, NM_005902, 3599036, 0000380136, IPR019471, GE56446, AF025295, BAA22032, 3598993, 205396_at, g1673576_3p_s_at, PF10401, 3599028, IPR001132, 11751185_a_at, Hs.742270, MIM:114500, CCDS10222, 0005860086, AK316017, AK290881, 3599014, 3599034, 11754091_s_at, AF025296, 3598961, CR749287, 218284_at, 3599038, 3598994, XM_006720506, EAW77788, CAB008094, UPI0000023A91, 1U7F, AAL68976, PH_hs_0048012, AB004930, CH471082, EntrezGene:4088, 44841_at, BAF83570, 7984364, XP_006720569, BAH14388, 3599023, AK298139, SMAD3-001, 38944_at, BC050743, 44986_s_at, 1MHD, 3599031, 3599035, BAH12731, H0YMP2, 3598992, ILMN_1682738, A_14_P107358, 1950_s_at, AF025300, U68019_at, 3599029, 11718265_a_at, SM00523, AF025297, AK300614, 1433_g_at, MIM:603109, 3598960, 4088, A_23_P48936, 11726549_a_at, 51059_at, g7661691_3p_at, AAB80960, SMAD3, 11718266_s_at, AF025299, H0YL71, AF025294, 3599030, BAH13315, 8774881, MIM:613795, PH_hs_0032513, 3599037, 3599040, H0YKE2, AC087482, OTTHUMP00000164305, g5174512_3p_s_at, AC012568, DKFZP686J10186, Hs.727986, 3599033, 2LAJ, AAB18967, 8673135, PF03166, ENSG00000166949, SM00524, Hs.211578.0.S3_3p_at, NP_005893, ENSP00000332973, PH_hs_0039929, 58763_at, H0YNV1, 1454_at, CAH18142, PF03165, U68019, IPR003619, AAH50743, HGNC:6769, 3599042, ENSP00000437757, UPI000047B413, OTTHUMP00000247915, CCDS53950, NP_001138574, NM_001145102, SMAD3-002, uc010ujr.2, 3598977, uc010ujs.2, NP_001138575, 3598984, OTTHUMP00000247916, UPI0001915047, NM_001145103, SMAD3-003, CCDS45288, ENSP00000401133, OTTHUMP00000247918, SMAD3-004, NP_001138576, CCDS53951, uc010ujt.2, 3598995, ENSP00000445348, NM_001145104, UPI000192B90A
Molecules with this sequenceSMAD3 [cytosol] UKENBCdOORHPGPPPPPURDDDDD
p-S423,S425-SMAD3 [cytosol] UKENBCdOORHPGPPPPPURDDDDD
p-S423,S425-SMAD3 [nucleoplasm] UKENBCdOORHPGPPPPPURDDDDD
SMAD3 [nucleoplasm] UKENBCdOORHPGPPPPPURDDDDD
p-T179,S423,S425-SMAD3 [nucleoplasm] UKENBCdOORHPGPPPPPURDDDDD
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] UKENBCdOORHPGPPPPPURDDDDD
SMAD3 S425C [cytosol] UKENBCdOORHPGPPPPPURDDDDD
p-S423,S425-SMAD3 R268C [cytosol] UKENBCdOORHPGPPPPPURDDDDD
p-S423,S425-SMAD3 R268H [cytosol] UKENBCdOORHPGPPPPPURDDDDD
p-S423,S425-SMAD3 D258N [cytosol] UKENBCdOORHPGPPPPPURDDDDD
SMAD3 D258N [cytosol] UKENBCdOORHPGPPPPPURDDDDD
SMAD3 R268H [cytosol] UKENBCdOORHPGPPPPPURDDDDD
SMAD3 R268C [cytosol] UKENBCdOORHPGPPPPPURDDDDD
Component ofSMAD3:STUB1 [cytosol]
Ub-SMAD3 [cytosol]
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]
SMAD2/3:PMEPA1 [plasma membrane]
p-2S-SMAD2/3:SMAD4 [cytosol]
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2/3 [early endosome membrane]
p-2S-SMAD2/3:PMEPA1 [early endosome membrane]
p-2S-SMAD2/3:MTMR4 [early endosome membrane]
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]
...
List all 31 items
Represented by generalisation(s)SMAD2/3 [cytosol]
p-2S-SMAD2/3 [cytosol]
p-2S-SMAD2/3 [nucleoplasm]
SMAD2/3 [nucleoplasm]
p-T,2S-SMAD2/3 [nucleoplasm]
p-2S-SMAD2/PAR-2S-SMAD3 [nucleoplasm]
SMAD3 Phosphorylation Motif Mutants [cytosol]
p-2S-SMAD3 MH2 Domain Mutants [cytosol]
SMAD3 MH2 Domain Mutants [cytosol]
SMAD2/3 Phosphorylation Motif Mutants [cytosol]
p-2S-SMAD2/3 MH2 Domain Mutants [cytosol]
SMAD2/3 MH2 Domain Mutants [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Ubiquitination of SKI/SKIL by Rnf11 [Homo sapiens]

Gene Expression

Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation [Homo sapiens]

Developmental Biology

Disease

Modifications in molecules with this sequenceO-phospho-L-serine at 425
O-phospho-L-serine at 423
O-phospho-L-threonine at 179
L-glutamyl-5-poly(ADP-ribose) at 52
L-glutamyl-5-poly(ADP-ribose) at 50
L-serine residue 425 replaced with L-cysteine
L-arginine residue 268 replaced with L-histidine
L-arginine residue 268 replaced with L-cysteine
L-aspartic acid residue 258 replaced with L-asparagine
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