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Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P84022
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Mothers against decapentaplegic homolog 3 shortName:MAD homolog 3 shortName:Mad3 shortName:Mothers against DPP homolog 3 shortName:hMAD-3 alternativeName: JV15-2 alternativeName: SMAD family member 3 shortName:SMAD 3 shortName:Smad3 shortName:hSMAD3
Links to corresponding entries in other databasesBioGPS Gene:4088
CTD Gene:4088
DOCK Blaster:1MHD
DOCK Blaster:1MJS
DOCK Blaster:1MK2
DOCK Blaster:1OZJ
DOCK Blaster:1U7F
ENSEMBL:ENSG00000166949
GeneCards:P84022
HapMap:NM_005902
KEGG Gene:4088
NCBI Gene:4088
OMIM:603109
Protein Data Bank:1MHD
Protein Data Bank:1MJS
Protein Data Bank:1MK2
Protein Data Bank:1OZJ
Protein Data Bank:1U7F
RefSeq:NM_005902
RefSeq:NP_005893
UCSC human:P84022
UniProt:P84022
dbSNP Gene:4088
Other identifiers related to this sequenceSMAD3_HUMAN, A8K4B6, B7Z4Z5, B7Z6M9, B7Z9Q2, F5H383, O09064, O09144, O14510, O35273, Q92940, Q93002, Q9GKR4, ENSG00000166949, ENST00000327367, ENSP00000332973, 1433_g_at, 1454_at, 1950_s_at, 205396_at, 205398_s_at, 205397_x_at, 218284_at, 38944_at, 44841_at, 44986_s_at, 65983_at, 51059_at, 58763_at, U68019_at, g5174512_3p_s_at, g7661691_3p_at, g1673576_3p_s_at, Hs.211578.0.S3_3p_at, A_14_P107358, A_23_P359091, A_23_P48936, A_23_P54406, CCDS10222, GE56446, GE79350, CR749287, AB209616, U68019, U76622, AB004930, AF025300, AF025293, AF025294, AF025295, AF025296, AF025297, AF025298, AF025299, BC050743, EntrezGene:4088, GI_42476202-S, GI_7661691-S, ILMN_16351, IPI00024305, MIM:603109, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, CAH18142, BAD92853, AAB80960, AAB18967, BAA22032, AAL68976, AAH50743, NM_005902, NP_005893, OTTHUMT00000256967, Hs.36915, Hs.618504, Hs.696294, Q68DS8, Q59F45, P84022, Q68DS8_HUMAN, Q59F45_HUMAN, SMAD3_HUMAN, IPR001132, IPR003619, IPR013019
Molecules with this sequenceSMAD3 [cytosol] UKENBCdORHGURPPPPPDDDDD
p-S423,S425-SMAD3 [cytosol] UKENBCdORHGURPPPPPDDDDD
p-S423,S425-SMAD3 [nucleoplasm] UKENBCdORHGURPPPPPDDDDD
SMAD3 [nucleoplasm] UKENBCdORHGURPPPPPDDDDD
p-T179,S423,S425-SMAD3 [nucleoplasm] UKENBCdORHGURPPPPPDDDDD
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] UKENBCdORHGURPPPPPDDDDD
SMAD3 S425C [cytosol] UKENBCdORHGURPPPPPDDDDD
p-S423,S425-SMAD3 R268C [cytosol] UKENBCdORHGURPPPPPDDDDD
p-S423,S425-SMAD3 R268H [cytosol] UKENBCdORHGURPPPPPDDDDD
p-S423,S425-SMAD3 D258N [cytosol] UKENBCdORHGURPPPPPDDDDD
SMAD3 D258N [cytosol] UKENBCdORHGURPPPPPDDDDD
SMAD3 R268H [cytosol] UKENBCdORHGURPPPPPDDDDD
SMAD3 R268C [cytosol] UKENBCdORHGURPPPPPDDDDD
Component ofSMAD3:STUB1 [cytosol]
Ub-SMAD3 [cytosol]
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]
SMAD2/3:PMEPA1 [plasma membrane]
p-2S-SMAD2/3:SMAD4 [cytosol]
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2/3 [early endosome membrane]
p-2S-SMAD2/3:PMEPA1 [early endosome membrane]
p-2S-SMAD2/3:MTMR4 [early endosome membrane]
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]
...
List all 31 items
Represented by generalisation(s)SMAD2/3 [cytosol]
p-2S-SMAD2/3 [cytosol]
p-2S-SMAD2/3 [nucleoplasm]
SMAD2/3 [nucleoplasm]
p-T,2S-SMAD2/3 [nucleoplasm]
p-2S-SMAD2/PAR-2S-SMAD3 [nucleoplasm]
SMAD3 Phosphorylation Motif Mutants [cytosol]
p-2S-SMAD3 MH2 Domain Mutants [cytosol]
SMAD3 MH2 Domain Mutants [cytosol]
SMAD2/3 Phosphorylation Motif Mutants [cytosol]
p-2S-SMAD2/3 MH2 Domain Mutants [cytosol]
SMAD2/3 MH2 Domain Mutants [cytosol]
Processes where molecules and complexes with this sequence are involved

Signal Transduction

Ubiquitination of SKI/SKIL by Rnf11 [Homo sapiens]

Gene Expression

Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation [Homo sapiens]

Developmental Biology

Disease

Modifications in molecules with this sequenceO-phospho-L-serine at 425
O-phospho-L-serine at 423
O-phospho-L-threonine at 179
L-glutamyl-5-poly(ADP-ribose) at 52
L-glutamyl-5-poly(ADP-ribose) at 50
L-serine residue 425 replaced with L-cysteine
L-arginine residue 268 replaced with L-histidine
L-arginine residue 268 replaced with L-cysteine
L-aspartic acid residue 258 replaced with L-asparagine
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