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Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:65200
_displayNameUniProt:Q15831 STK11
_timestamp2014-11-19 11:05:35
checksum6DF4C37AB7A89569
commentCOFACTOR Magnesium or Manganese.TISSUE SPECIFICITY Ubiquitously expressed. Strongest expression in testis and fetal liver.DISEASE Defects in STK11 are associated with some sporadic cancers, especially lung cancers. Frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Defects promote lung cancerigenesis process, especially lung cancer progression and metastasis. Confers lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma. Also able to promotes lung cancer metastasis, via both cancer-cell autonomous and non-cancer-cell autonomous mechanisms.
crossReference[DatabaseIdentifier:6578281] PRO:Q15831
[DatabaseIdentifier:6613482] GeneCards:Q15831
[DatabaseIdentifier:6638025] UCSC human:Q15831
[DatabaseIdentifier:6644810] RefSeq:NP_000446
[DatabaseIdentifier:6712668] ZINC_target:Q15831
[DatabaseIdentifier:6717111] HMDB_protein:HMDBP01530
descriptionrecommendedName: Serine/threonine-protein kinase STK11 ecNumber2.7.11.1/ecNumber alternativeName: Liver kinase B1 shortName:LKB1 shortName:hLKB1 alternativeName: Renal carcinoma antigen NY-REN-19
geneNameSTK11
LKB1
PJS
identifierQ15831
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Alternative splicing
Apoptosis
ATP-binding
Autophagy
Cell cycle
Complete proteome
Cytoplasm
Differentiation
Disease mutation
DNA damage
Kinase
Lipoprotein
Magnesium
Manganese
Membrane
Metal-binding
Methylation
Mitochondrion
Nucleotide-binding
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Prenylation
Reference proteome
Serine/threonine-protein kinase
Spermatogenesis
Transferase
Tumor suppressor
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5083144] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:6348073] Croft, D
[InstanceEdit:6378953] Croft, D
[InstanceEdit:6410971] Croft, D
[InstanceEdit:6442989] Croft, D
[InstanceEdit:6475007] Croft, D
[InstanceEdit:6507025] Croft, D
[InstanceEdit:6609128] Croft, D
[InstanceEdit:6626660] Croft, D
[InstanceEdit:6633671] Croft, D
[InstanceEdit:6641434] Croft, D
[InstanceEdit:6672501] Croft, D
[InstanceEdit:6688369] Croft, D
[InstanceEdit:6710999] Croft, D
[InstanceEdit:6715121] Croft, D
nameSTK11
otherIdentifier0005050725
11735699_x_at
204292_x_at
231017_at
2WTK
3815588
3815591
3815595
3815596
3815597
3815602
3815603
3815605
41657_at
6794
86312_at
A_23_P16483
A_24_P159866
A_33_P3389148
AAB05809
AAB97833
AAC15742
AAC39527
AAF97257
AAH07981
AAH19334
AC004221
AC011544
AF032984
AF035625
AF055320
AF055321
AF055322
AF055323
AF055324
AF055325
AF055326
AF055327
AK314858
BAG37374
BC007981
BC019334
CAB016231
CAB022105
CCDS45896
CH471139
EAW69540
ENSG00000118046
ENSP00000324856
ENST00000326873
EntrezGene:6794
g4507270_3p_s_at
GE60471
HGNC:11389
HPA017254
Hs.155647.0.S1_3p_at
Hs.515005
Hs.738438
ILMN_1751871
IPR000719
IPR001245
IPR002290
IPR011009
IPR020635
LRG_319
LRG_319t1
MIM:175200
MIM:273300
MIM:602216
NM_000455
NP_000446
OTTHUMP00000263382
PF00069
PF07714
PH_hs_0015564
Q9NS52
SM00219
SM00220
STK11
STK11-001
U63333
uc002lrl.1
UPI0000136105
XM_005259617
XP_005259674
XP_005259675
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6694752] KEGG Gene:6794 serine/threonine kinase 11 [Homo sapiens]
[ReferenceDNASequence:6351522] ENSEMBL:ENSG00000118046 [Homo sapiens]
[ReferenceDNASequence:6382403] NCBI Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6424307] BioGPS Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6456325] CTD Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6488343] dbSNP Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6628332] OMIM:175200 [Homo sapiens]
[ReferenceDNASequence:6628333] OMIM:602216 [Homo sapiens]
[ReferenceDNASequence:6700253] Orphanet:15565 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6676340] RefSeq:NM_000455
secondaryIdentifierSTK11_HUMAN
B2RBX7
E7EW76
sequenceLength433
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:164119] STK11 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:380954] STK11(1-433) [cytosol] [Homo sapiens]
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