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Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:65200
_displayNameUniProt:Q15831 STK11
_timestamp2014-09-11 06:48:10
checksum6DF4C37AB7A89569
commentCOFACTOR Magnesium or Manganese.TISSUE SPECIFICITY Ubiquitously expressed. Strongest expression in testis and fetal liver.DISEASE Defects in STK11 are associated with some sporadic cancers, especially lung cancers. Frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Defects promote lung cancerigenesis process, especially lung cancer progression and metastasis. Confers lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma. Also able to promotes lung cancer metastasis, via both cancer-cell autonomous and non-cancer-cell autonomous mechanisms.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.SIMILARITY Contains 1 protein kinase domain.
crossReference[DatabaseIdentifier:6587405] PRO:Q15831
[DatabaseIdentifier:6623268] GeneCards:Q15831
[DatabaseIdentifier:6647456] UCSC human:Q15831
[DatabaseIdentifier:6654122] RefSeq:NP_000446
descriptionrecommendedName: Serine/threonine-protein kinase STK11 ecNumber2.7.11.1/ecNumber alternativeName: Liver kinase B1 shortName:LKB1 shortName:hLKB1 alternativeName: Renal carcinoma antigen NY-REN-19
geneNameSTK11
LKB1
PJS
identifierQ15831
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Apoptosis
ATP-binding
Autophagy
Cell cycle
Complete proteome
Cytoplasm
Disease mutation
DNA damage
Kinase
Lipoprotein
Magnesium
Manganese
Membrane
Metal-binding
Methylation
Mitochondrion
Nucleotide-binding
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Prenylation
Reference proteome
Serine/threonine-protein kinase
Transferase
Tumor suppressor
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5083144] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:6348050] Croft, D
[InstanceEdit:6379983] Croft, D
[InstanceEdit:6413044] Croft, D
[InstanceEdit:6446105] Croft, D
[InstanceEdit:6479166] Croft, D
[InstanceEdit:6512227] Croft, D
[InstanceEdit:6618954] Croft, D
[InstanceEdit:6636231] Croft, D
[InstanceEdit:6643142] Croft, D
[InstanceEdit:6650745] Croft, D
[InstanceEdit:6682804] Croft, D
[InstanceEdit:6698332] Croft, D
nameSTK11
otherIdentifierXP_005259674
Hs.515005
41657_at
AF055322
AF055323
PF07714
SM00219
Q9NS52
NP_000446
SM00220
3815597
AAF97257
CAB016231
IPR001245
HGNC:11389
CH471139
3815589
BC019334
3815581
3815591
NM_000455
3815593
A_33_P3389148
XP_005259675
A_23_P16483
AAB05809
AAH19334
2WTK
IPR000719
U63333
uc002lrl.1
3815580
AF032984
MIM:602216
3815596
AF055325
ILMN_1751871
MIM:273300
AK314858
3815588
3815605
A_24_P159866
6794
STK11-001
CAB022105
AF035625
231017_at
STK11
AF055326
11735699_x_at
3815604
IPR002290
MIM:175200
IPR011009
204292_x_at
CCDS45896
8024204
ENST00000326873
86312_at
EAW69540
LRG_319
Hs.155647.0.S1_3p_at
3815582
AF055324
3815598
16856463
AF055320
OTTHUMP00000263382
PF00069
HPA017254
g4507270_3p_s_at
3815595
9425897
PH_hs_0015564
AF055327
3815603
AAB97833
UPI0000136105
AC011544
LRG_319t1
AAC39527
ENSG00000118046
AC004221
0005050725
Hs.738438
BC007981
AAC15742
EntrezGene:6794
XM_005259617
AAH07981
ENSP00000324856
AF055321
GE60471
3815602
BAG37374
IPR020635
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6704669] KEGG Gene:6794 serine/threonine kinase 11 [Homo sapiens]
[ReferenceDNASequence:6351561] ENSEMBL:ENSG00000118046 [Homo sapiens]
[ReferenceDNASequence:6383534] NCBI Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6426633] BioGPS Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6459694] CTD Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6492755] dbSNP Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6637877] OMIM:175200 [Homo sapiens]
[ReferenceDNASequence:6637878] OMIM:602216 [Homo sapiens]
[ReferenceDNASequence:6722803] Orphanet:15565 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6686563] RefSeq:NM_000455
secondaryIdentifierSTK11_HUMAN
B2RBX7
E7EW76
sequenceLength433
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:164119] STK11 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:380954] STK11(1-433) [cytosol] [Homo sapiens]
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