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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:65200
_displayNameUniProt:Q15831 STK11
_timestamp2014-05-28 17:17:50
checksum6DF4C37AB7A89569
commentCOFACTOR Magnesium or Manganese.TISSUE SPECIFICITY Ubiquitously expressed. Strongest expression in testis and fetal liver.DISEASE Defects in STK11 are associated with some sporadic cancers, especially lung cancers. Frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Defects promote lung cancerigenesis process, especially lung cancer progression and metastasis. Confers lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma. Also able to promotes lung cancer metastasis, via both cancer-cell autonomous and non-cancer-cell autonomous mechanisms.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.SIMILARITY Contains 1 protein kinase domain.
crossReference[DatabaseIdentifier:6444384] GeneCards:Q15831
[DatabaseIdentifier:6458697] UCSC human:Q15831
[DatabaseIdentifier:6465238] RefSeq:NP_000446
descriptionrecommendedName: Serine/threonine-protein kinase STK11 ecNumber2.7.11.1/ecNumber alternativeName: Liver kinase B1 shortName:LKB1 shortName:hLKB1 alternativeName: Renal carcinoma antigen NY-REN-19
geneNameSTK11
LKB1
PJS
identifierQ15831
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Apoptosis
ATP-binding
Autophagy
Cell cycle
Complete proteome
Cytoplasm
Disease mutation
DNA damage
Kinase
Lipoprotein
Magnesium
Manganese
Membrane
Metal-binding
Methylation
Mitochondrion
Nucleotide-binding
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Prenylation
Reference proteome
Serine/threonine-protein kinase
Transferase
Tumor suppressor
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5083144] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:6281038] Croft, D
[InstanceEdit:6311957] Croft, D
[InstanceEdit:6343996] Croft, D
[InstanceEdit:6376035] Croft, D
[InstanceEdit:6408074] Croft, D
[InstanceEdit:6440113] Croft, D
[InstanceEdit:6447579] Croft, D
[InstanceEdit:6454426] Croft, D
[InstanceEdit:6461892] Croft, D
[InstanceEdit:6492909] Croft, D
[InstanceEdit:6508136] Croft, D
nameSTK11
otherIdentifierENSG00000118046
ENST00000326873
ENSP00000324856
41657_at
231019_x_at
1552355_s_at
215325_x_at
231017_at
204292_x_at
33696_at
33695_at
60026_at
86312_at
Hs.193187.0.S1_3p_x_at
Hs.155647.0.S1_3p_at
Hs.155647.0.A1_3p_x_at
Hs.155647.0.A1_3p_at
Hs2.346575.1.S1_3p_s_at
g4507270_3p_s_at
Hs.193187.0.S1_3p_at
A_23_P16483
A_24_P159866
GE60471
AC004221
AJ844634
AF217978
AF035625
U63333
AF032984
AF055327
AF055320
AF055321
AF055322
AF055323
AF055324
AF055325
AF055326
BC007981
BC019334
EntrezGene:6794
GI_21361613-S
ILMN_15023
IPI00219072
MIM:602216
MIM:175200
AAF97257
CAH59749
AAG17221
AAC39527
AAB05809
AAB97833
AAC15742
AAH07981
AAH19334
NM_000455
NP_000446
Hs.619942
Q9NS52
Q5ZEZ1
Q9HBS3
Q15831
Q9NS52_HUMAN
Q5ZEZ1_HUMAN
Q9HBS3_HUMAN
STK11_HUMAN
IPR000719
IPR008271
IPR001245
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6514421] KEGG Gene:6794 serine/threonine kinase 11 [Homo sapiens]
[ReferenceDNASequence:6284525] ENSEMBL:ENSG00000118046 [Homo sapiens]
[ReferenceDNASequence:6315473] NCBI Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6357288] BioGPS Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6389327] CTD Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6421366] dbSNP Gene:6794 [Homo sapiens]
[ReferenceDNASequence:6449216] OMIM:175200 [Homo sapiens]
[ReferenceDNASequence:6449217] OMIM:602216 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6496596] RefSeq:NM_000455
secondaryIdentifierSTK11_HUMAN
B2RBX7
E7EW76
sequenceLength433
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:164119] STK11 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:380954] STK11(1-433) [cytosol] [Homo sapiens]
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