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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:65242
_displayNameUniProt:P08842 STS
_timestamp2014-05-28 17:17:50
checksum74746AFA9D21A0A6
commentFUNCTION Conversion of sulfated steroid precursors to estrogens during pregnancy.CATALYTIC ACTIVITY 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.SUBUNIT Homodimer.SIMILARITY Belongs to the sulfatase family.
crossReference[DatabaseIdentifier:6441572] GeneCards:P08842
[DatabaseIdentifier:6455885] UCSC human:P08842
[DatabaseIdentifier:6471173] RefSeq:NP_000342
[DatabaseIdentifier:6525546] Protein Data Bank:1P49
[DatabaseIdentifier:6532286] DOCK Blaster:1P49
descriptionrecommendedName: Steryl-sulfatase ecNumber3.1.6.2/ecNumber alternativeName: Arylsulfatase C shortName:ASC alternativeName: Steroid sulfatase alternativeName: Steryl-sulfate sulfohydrolase
geneNameSTS
ARSC1
identifierP08842
isSequenceChangedFALSE
keyword3D-structure
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Ichthyosis
Lipid metabolism
Membrane
Metal-binding
Pregnancy
Reference proteome
Signal
Steroid metabolism
Transmembrane
Transmembrane helix
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:6281038] Croft, D
[InstanceEdit:6311957] Croft, D
[InstanceEdit:6343996] Croft, D
[InstanceEdit:6376035] Croft, D
[InstanceEdit:6408074] Croft, D
[InstanceEdit:6440113] Croft, D
[InstanceEdit:6447579] Croft, D
[InstanceEdit:6454426] Croft, D
[InstanceEdit:6461892] Croft, D
[InstanceEdit:6492909] Croft, D
[InstanceEdit:6508136] Croft, D
[InstanceEdit:6518483] Croft, D
[InstanceEdit:6528104] Croft, D
nameSTS
otherIdentifierENSG00000101846
ENST00000217961
ENSP00000217961
203767_s_at
203770_s_at
203769_s_at
203768_s_at
38034_at
M16505_at
g338564_3p_a_at
Hs.79876.0.A2_3p_a_at
g13162281_3p_a_at
Hs.79876.0.A3_3p_a_at
A_14_P102729
A_14_P110858
A_24_P331560
A_23_P33293
A_32_P414078
A_32_P382525
A_32_P391227
A_32_P505641
CCDS14127
GE57842
J04964
M16505
BC075030
M23945
M23556
EntrezGene:412
GI_13162281-S
ILMN_25374
IPI00307433
MIM:308100
OTTHUMT00000055686
1P49
AAA60597
AAA60596
AAH75030
AAA60598
AAA60599
NM_000351
NP_000342
Hs.522578
P08842
STS_HUMAN
IPR000917
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6510340] KEGG Gene:412 steroid sulfatase (microsomal), isozyme S [Homo sapiens]
[ReferenceDNASequence:6289930] ENSEMBL:ENSG00000101846 [Homo sapiens]
[ReferenceDNASequence:6320840] NCBI Gene:412 [Homo sapiens]
[ReferenceDNASequence:6348249] BioGPS Gene:412 [Homo sapiens]
[ReferenceDNASequence:6380288] CTD Gene:412 [Homo sapiens]
[ReferenceDNASequence:6412327] dbSNP Gene:412 [Homo sapiens]
[ReferenceDNASequence:6454360] OMIM:308100 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6507970] RefSeq:NM_000351
secondaryIdentifierSTS_HUMAN
B2RA47
sequenceLength583
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:1606833] OxA-STS [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1614318] STS [endoplasmic reticulum lumen] [Homo sapiens]
[EntityWithAccessionedSequence:1614333] OxA-STS [endoplasmic reticulum lumen] [Homo sapiens]
(referenceSequence)[ModifiedResidue:1614323] L-3-oxoalanine (Ser) at 75
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