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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:65242
_displayNameUniProt:P08842 STS
_timestamp2014-09-11 06:48:11
checksum74746AFA9D21A0A6
commentFUNCTION Conversion of sulfated steroid precursors to estrogens during pregnancy.CATALYTIC ACTIVITY 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.SUBUNIT Homodimer.SIMILARITY Belongs to the sulfatase family.
crossReference[DatabaseIdentifier:6575679] PRO:P08842
[DatabaseIdentifier:6620423] GeneCards:P08842
[DatabaseIdentifier:6633642] Protein Data Bank:1P49
[DatabaseIdentifier:6644611] UCSC human:P08842
[DatabaseIdentifier:6660177] RefSeq:NP_000342
[DatabaseIdentifier:6715503] DOCK Blaster:1P49
descriptionrecommendedName: Steryl-sulfatase ecNumber3.1.6.2/ecNumber alternativeName: Arylsulfatase C shortName:ASC alternativeName: Steroid sulfatase alternativeName: Steryl-sulfate sulfohydrolase
geneNameSTS
ARSC1
identifierP08842
isSequenceChangedFALSE
keyword3D-structure
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Ichthyosis
Lipid metabolism
Membrane
Metal-binding
Pregnancy
Reference proteome
Signal
Steroid metabolism
Transmembrane
Transmembrane helix
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:6348050] Croft, D
[InstanceEdit:6379983] Croft, D
[InstanceEdit:6413044] Croft, D
[InstanceEdit:6446105] Croft, D
[InstanceEdit:6479166] Croft, D
[InstanceEdit:6512227] Croft, D
[InstanceEdit:6618954] Croft, D
[InstanceEdit:6626557] Croft, D
[InstanceEdit:6636231] Croft, D
[InstanceEdit:6643142] Croft, D
[InstanceEdit:6650745] Croft, D
[InstanceEdit:6682804] Croft, D
[InstanceEdit:6698332] Croft, D
[InstanceEdit:6711320] Croft, D
nameSTS
otherIdentifierA_14_P102729
11724832_at
3967741
NP_000342
Hs.79876.0.A3_3p_a_at
PF01663
203769_s_at
AAA60597
AAA60599
PH_hs_0042046
3967722
M23556
1P49
11724830_at
11724831_at
J04964
3967695
STS-001
GE57842
17101292
38034_at
203768_s_at
AAA60596
3967744
3967693
3967738
3967701
STS
203770_s_at
g338564_3p_a_at
PF00884
PH_hs_0031356
203767_s_at
3967739
AAH75030
Hs.522578
g13162281_3p_a_at
CCDS14127
OTTHUMP00000022868
3967708
0004570040
uc004cry.4
XP_005274568
A_24_P331560
3967743
IPR017850
3967742
8165866
EntrezGene:412
MIM:300747
M16505
11724829_at
BAG36744
3967697
AK314034
M16505_at
IPR002591
HGNC:11425
MIM:308100
3967718
3967737
AAA60598
3967725
ENSP00000217961
3967736
3967740
3967702
UPI0000136153
3967698
412
ILMN_1778956
ENSG00000101846
M23945
XM_005274511
A_14_P110858
XP_006724551
XM_006724488
BC075030
3967735
3967703
NM_000351
HPA002904
Hs.79876.0.A2_3p_a_at
3967696
IPR000917
3967709
3967692
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6700553] KEGG Gene:412 steroid sulfatase (microsomal), isozyme S [Homo sapiens]
[ReferenceDNASequence:6357072] ENSEMBL:ENSG00000101846 [Homo sapiens]
[ReferenceDNASequence:6389003] NCBI Gene:412 [Homo sapiens]
[ReferenceDNASequence:6417397] BioGPS Gene:412 [Homo sapiens]
[ReferenceDNASequence:6450458] CTD Gene:412 [Homo sapiens]
[ReferenceDNASequence:6483519] dbSNP Gene:412 [Homo sapiens]
[ReferenceDNASequence:6643075] OMIM:308100 [Homo sapiens]
[ReferenceDNASequence:6721903] Orphanet:15566 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6698160] RefSeq:NM_000351
secondaryIdentifierSTS_HUMAN
B2RA47
sequenceLength583
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:1606833] OxA-STS [endoplasmic reticulum membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1614318] STS [endoplasmic reticulum lumen] [Homo sapiens]
[EntityWithAccessionedSequence:1614333] OxA-STS [endoplasmic reticulum lumen] [Homo sapiens]
(referenceSequence)[ModifiedResidue:1614323] L-3-oxoalanine (Ser) at 75
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