instancebrowser | sectioned | sidebarwithdynamichierarchy
Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P36897
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: TGF-beta receptor type-1 shortName:TGFR-1 ecNumber2.7.11.30/ecNumber alternativeName: Activin A receptor type II-like protein kinase of 53kD alternativeName: Activin receptor-like kinase 5 shortName:ALK-5 shortName:ALK5 alternativeName: Serine/threonine-protein kinase receptor R4 shortName:SKR4 alternativeName: TGF-beta type I receptor alternativeName: Transforming growth factor-beta receptor type I shortName:TGF-beta receptor type I shortName:TbetaR-I
Links to corresponding entries in other databasesBioGPS Gene:7046
Brenda:2.7.11.30
CTD Gene:7046
DOCK Blaster:1B6C
DOCK Blaster:1IAS
DOCK Blaster:1PY5
DOCK Blaster:1RW8
DOCK Blaster:1TBI
DOCK Blaster:1VJY
EC:2.7.11.30
ENSEMBL:ENSG00000106799
GeneCards:P36897
HapMap:NM_004612
IntEnz:2.7.11.30
KEGG Gene:7046
NCBI Gene:7046
OMIM:190181
OMIM:609192
OMIM:610168
OMIM:610380
Orphanet:15610
PRO:P36897
Protein Data Bank:1B6C
Protein Data Bank:1IAS
Protein Data Bank:1PY5
Protein Data Bank:1RW8
Protein Data Bank:1TBI
Protein Data Bank:1VJY
RefSeq:NM_004612
RefSeq:NP_004603
UCSC human:P36897
UniProt:P36897
dbSNP Gene:7046
Other identifiers related to this sequenceTGFR1_HUMAN, Q6IR47, Q706C0, Q706C1, ILMN_1745927, DQ383423, 3181779, MIM:608967, SM00219, Hs.625128, DQ383416, AF035662, EAW58905, 1319842, 0000870154, 1957_s_at, 3FAA, IPR001245, MIM:609192, AAC08998, g4759225_3p_at, AF035666, UPI000011D62A, 3181768, NM_004612, 3181747, 32903_at, 21358634, AF035664, 3TZM, CH471105, 8530052, AF054598, L11695_at, XM_005252150, AF054597, AF054596, 11758014_s_at, AF054594, AY497473, MIM:190181, 3181748, BC071181, DQ383420, IPR011009, 11746441_a_at, AJ619019, AF035669, A_23_P123943, 3181762, 2X7O, ILMN_1797611, Hs.494622, BAG63588, 3181764, Hs.623256, DQ383422, CAF02097, L11695, 1IAS, 3181766, AF054591, IPR000472, XP_005252207, DQ383419, 3181729, OTTHUMP00000021783, ENSG00000106799, 1VJY, PF01064, AJ619020, 8156826, AAH71181, CCDS6738, 3181752, 2PJY, PF07714, 206943_at, 3181767, 1B6C, GE80220, SM00220, 3181756, AF054593, PF08515, DQ383417, DQ383424, 3181730, 17087480, uc004azc.3, A_14_P111822, ACZ58375, Q5T7S2, 3181777, EntrezGene:7046, 3KFD, AF035663, GU143401, AL162427, 2WOU, 52307_at, IPR003605, AF035670, DQ383421, IPR000719, 1TBI, AF035667, PH_hs_0049025, 3181760, SM00467, AF054595, AAA16073, MIM:132800, B4DY26, IPR002290, IPR002638, 11739462_a_at, AF054592, 7046, 224793_s_at, 3181769, 3HMM, TGFBR1, CAB031481, AF035665, 3181754, TGFBR1-001, 1PY5, HGNC:11772, AAD02042, AF035668, 1RW8, 49222_at, ABD46753, A_33_P3331451, 3181763, 44127_at, PF00069, 3GXL, DQ383418, NP_004603, CAF02096, 2WOT, 3KCF, 2L5S, PH_hs_0022072, AK302234, 52539_at, CAB002441, 3181758, Hs.28005.0.S1_3p_a_at, F8VVC4, IPR020635, AAR32097, AF054590, ENSP00000364133, 3181765, NP_001124388, TGFBR1-003, ENSP00000364129, uc004azd.3, F8VXZ5, UPI00003782E5, CCDS47998, NM_001130916, OTTHUMP00000242324, F8VRH6, uc004aze.3, ENSP00000447297, UPI00020B16FD, TGFBR1-004, OTTHUMP00000242326, F8W0K6
Molecules with this sequenceTGFBR1 [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
p-4S,T185,T186-TGFBR1 [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 P83S [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 C41Y [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 P83L [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 N45S [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 G52R [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 D269_Q324del [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 W242* [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 P327Qfs*8 [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 R414* [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
TGFBR1 L354Nfs*4 [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
p-4S,T185,T186-TGFBR1 W242* [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
p-4S,T185,T186-TGFBR1 P327Qfs*8 [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
p-4S,T185,T186-TGFBR1 L354Nfs*4 [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
p-4S,T185,T186-TGFBR1 R414* [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane] UKENBCdOOOOORHPGPPPPPPURDDDDDD
GS domain
Component ofTGFBR1 homodimer [plasma membrane]
TGFBR1:FKBP1A [plasma membrane]
p-TGFBR1 [plasma membrane]
TGFB1:TGFBR2:TGFBR1 [plasma membrane]
Tight Junction Complex:TGFBR1:Pard6a:RHOA [cell junction]
TGFB1:TGFBR2:TGFBR1 [early endosome membrane]
TGFB1:TGFBR2 KD Mutants:TGFBR1 [plasma membrane]
Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction]
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane]
...
List all 44 items
Represented by generalisation(s)TGFBR1 LBD Mutants [plasma membrane]
TGFBR1 KD Mutants [plasma membrane]
p-4S-T185,T186-TGFBR1 KD Mutants [plasma membrane]
Processes where molecules and complexes with this sequence are involved

PP1CC dephosphorylates TGFBR1 [Homo sapiens]

Smad7 recruits NEDD4L to activated TGF-beta receptor complex [Homo sapiens]

SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1 [Homo sapiens]

Uchl5 is recruited to TGF-beta receptor complex through Smad7 [Homo sapiens]

Smad7:SMURF2 binds phosphorylated TGFBR1 [Homo sapiens]

SMURF2 ubiquitinates Smad7 and phosphorylated TGFBR1 [Homo sapiens]

TGFBR1 is recruited to tight junction by binding Pard6a [Homo sapiens]

Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex [Homo sapiens]

Disease

TGFBR2 phosphorylates Pard6a [Homo sapiens]

Smad7:SMURF1 binds phosphorylated TGFBR1 [Homo sapiens]

TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation [Homo sapiens]

Signal Transduction

NEDD4L ubiquitinates Smad7 and TGFBR1 [Homo sapiens]

Strap binds phosphorylated TGF-beta receptor complex [Homo sapiens]

Uchl5 deubiquitinates TGFBR1 [Homo sapiens]

Modifications in molecules with this sequenceO-phospho-L-serine at 165
O-phospho-L-threonine at 186
O-phospho-L-threonine at 185
O-phospho-L-serine at 187
O-phospho-L-serine at 191
O-phospho-L-serine at 189
L-proline 83 replaced with L-serine
L-asparagine 45 replaced with L-serine
L-cysteine 41 replaced with L-tyrosine
L-proline 83 replaced with L-leucine
glycine 52 replaced with L-arginine
Deletion of residues 269 to 324
L-arginine 332 replaced with L-glutamic acid
L-aspartic acid 333 replaced with L-isoleucine
L-isoleucine 329 replaced with L-leucine
L-proline 327 replaced with L-glutamine
L-histidine 331 replaced with L-isoleucine
L-valine 356 replaced with L-glutamine
L-alanine 330 replaced with L-leucine
L-alanine 355 replaced with L-lysine
L-leucine 354 replaced with L-asparagine
L-alanine 328 replaced with L-proline
DomainsGS domain
[Change default viewing format]