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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P36897
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: TGF-beta receptor type-1 shortName:TGFR-1 ecNumber2.7.11.30/ecNumber alternativeName: Activin A receptor type II-like protein kinase of 53kD alternativeName: Activin receptor-like kinase 5 shortName:ALK-5 shortName:ALK5 alternativeName: Serine/threonine-protein kinase receptor R4 shortName:SKR4 alternativeName: TGF-beta type I receptor alternativeName: Transforming growth factor-beta receptor type I shortName:TGF-beta receptor type I shortName:TbetaR-I
Links to corresponding entries in other databasesBioGPS Gene:7046
Brenda:2.7.11.30
CTD Gene:7046
DOCK Blaster:1B6C
DOCK Blaster:1IAS
DOCK Blaster:1PY5
DOCK Blaster:1RW8
DOCK Blaster:1TBI
DOCK Blaster:1VJY
EC:2.7.11.30
ENSEMBL:ENSG00000106799
GeneCards:P36897
HapMap:NM_004612
IntEnz:2.7.11.30
KEGG Gene:7046
NCBI Gene:7046
OMIM:190181
OMIM:609192
OMIM:610168
OMIM:610380
Protein Data Bank:1B6C
Protein Data Bank:1IAS
Protein Data Bank:1PY5
Protein Data Bank:1RW8
Protein Data Bank:1TBI
Protein Data Bank:1VJY
RefSeq:NM_004612
RefSeq:NP_004603
UCSC human:P36897
UniProt:P36897
dbSNP Gene:7046
Other identifiers related to this sequenceTGFR1_HUMAN, Q6IR47, Q706C0, Q706C1, ENSG00000106799, ENST00000374994, ENSP00000364133, 1957_s_at, 206943_at, 224793_s_at, 32903_at, 49222_at, 52307_at, 44127_at, 52539_at, 69737_at, L11695_at, g4759225_3p_at, Hs.28005.0.S1_3p_a_at, A_14_P111822, A_32_P146394, A_23_P123943, CCDS6738, GE523245, GE80220, AJ619019, AJ619020, DQ383424, DQ383416, DQ383417, DQ383418, DQ383419, DQ383420, DQ383421, DQ383422, DQ383423, AL162427, L11695, AF054598, AF054590, AF054591, AF054592, AF054593, AF054594, AF054595, AF054596, AF054597, AF035670, AF035662, AF035663, AF035664, AF035665, AF035666, AF035667, AF035668, AF035669, AY497473, BC071181, EntrezGene:7046, GI_4759225-S, ILMN_20708, IPI00005733, IPI00844074, MIM:190181, MIM:609192, MIM:610168, MIM:610380, OTTHUMT00000053390, 1B6C, 1IAS, 1PY5, 1RW8, 1TBI, 1VJY, CAF02096, CAF02097, ABD46753, CAI17140, AAA16073, AAC08998, AAD02042, AAR32097, AAH71181, NM_004612, NP_004603, Hs.494622, Hs.623256, Hs.625128, Hs.644939, Q706C1, Q706C0, Q5T7S2, P36897, Q6IR47, Q706C1_HUMAN, Q706C0_HUMAN, Q5T7S2_HUMAN, TGFR1_HUMAN, Q6IR47_HUMAN, IPR000719, IPR008271, IPR000333, IPR001245, IPR000472, IPR003605
Molecules with this sequenceTGFBR1 [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
p-4S,T185,T186-TGFBR1 [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 P83S [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 C41Y [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 P83L [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 N45S [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 G52R [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 D269_Q324del [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 W242* [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 P327Qfs*8 [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 R414* [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
TGFBR1 L354Nfs*4 [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
p-4S,T185,T186-TGFBR1 W242* [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
p-4S,T185,T186-TGFBR1 P327Qfs*8 [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
p-4S,T185,T186-TGFBR1 L354Nfs*4 [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
p-4S,T185,T186-TGFBR1 R414* [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane] UKENBCdOOOORHGURPPPPPPDDDDDD
GS domain
Component ofTGFBR1 homodimer [plasma membrane]
TGFBR1:FKBP1A [plasma membrane]
p-TGFBR1 [plasma membrane]
TGFB1:TGFBR2:TGFBR1 [plasma membrane]
Tight Junction Complex:TGFBR1:Pard6a:RHOA [cell junction]
TGFB1:TGFBR2:TGFBR1 [early endosome membrane]
TGFB1:TGFBR2 KD Mutants:TGFBR1 [plasma membrane]
Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction]
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane]
...
List all 44 items
Represented by generalisation(s)TGFBR1 LBD Mutants [plasma membrane]
TGFBR1 KD Mutants [plasma membrane]
p-4S-T185,T186-TGFBR1 KD Mutants [plasma membrane]
Processes where molecules and complexes with this sequence are involved

PP1CC dephosphorylates TGFBR1 [Homo sapiens]

Smad7 recruits NEDD4L to activated TGF-beta receptor complex [Homo sapiens]

SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1 [Homo sapiens]

Uchl5 is recruited to TGF-beta receptor complex through Smad7 [Homo sapiens]

Smad7:SMURF2 binds phosphorylated TGFBR1 [Homo sapiens]

SMURF2 ubiquitinates Smad7 and phosphorylated TGFBR1 [Homo sapiens]

TGFBR1 is recruited to tight junction by binding Pard6a [Homo sapiens]

Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex [Homo sapiens]

Disease

TGFBR2 phosphorylates Pard6a [Homo sapiens]

Smad7:SMURF1 binds phosphorylated TGFBR1 [Homo sapiens]

TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation [Homo sapiens]

Signal Transduction

NEDD4L ubiquitinates Smad7 and TGFBR1 [Homo sapiens]

Strap binds phosphorylated TGF-beta receptor complex [Homo sapiens]

Uchl5 deubiquitinates TGFBR1 [Homo sapiens]

Modifications in molecules with this sequenceO-phospho-L-serine at 165
O-phospho-L-threonine at 186
O-phospho-L-threonine at 185
O-phospho-L-serine at 187
O-phospho-L-serine at 191
O-phospho-L-serine at 189
L-proline 83 replaced with L-serine
L-asparagine 45 replaced with L-serine
L-cysteine 41 replaced with L-tyrosine
L-proline 83 replaced with L-leucine
glycine 52 replaced with L-arginine
Deletion of residues 269 to 324
L-arginine 332 replaced with L-glutamic acid
L-aspartic acid 333 replaced with L-isoleucine
L-isoleucine 329 replaced with L-leucine
L-proline 327 replaced with L-glutamine
L-histidine 331 replaced with L-isoleucine
L-valine 356 replaced with L-glutamine
L-alanine 330 replaced with L-leucine
L-alanine 355 replaced with L-lysine
L-leucine 354 replaced with L-asparagine
L-alanine 328 replaced with L-proline
DomainsGS domain
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