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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:67444
_displayNameUniProt:P18074 ERCC2
_timestamp2014-09-11 06:49:25
checksum746C0888CDF2E331
commentCATALYTIC ACTIVITY ATP + H(2)O = ADP + phosphate.SIMILARITY Belongs to the helicase family. RAD3/XPD subfamily.SIMILARITY Contains 1 helicase ATP-binding domain.
crossReference[DatabaseIdentifier:6576998] PRO:P18074
[DatabaseIdentifier:6620878] GeneCards:P18074
[DatabaseIdentifier:6645066] UCSC human:P18074
[DatabaseIdentifier:6655736] RefSeq:NP_000391
descriptionrecommendedName: TFIIH basal transcription factor complex helicase XPD subunit ecNumber3.6.4.12/ecNumber alternativeName: Basic transcription factor 2 80 kDa subunit shortName:BTF2 p80 alternativeName: CXPD alternativeName: DNA excision repair protein ERCC-2 alternativeName: DNA repair protein complementing XP-D cells alternativeName: TFIIH basal transcription factor complex 80 kDa subunit shortName:TFIIH 80 kDa subunit shortName:TFIIH p80 alternativeName: Xeroderma pigmentosum group D-complementing protein
geneNameERCC2
XPD
XPDC
identifierP18074
isSequenceChangedFALSE
keyword4Fe-4S
Alternative splicing
ATP-binding
Cataract
Chromosome partition
Cockayne syndrome
Complete proteome
Cytoplasm
Cytoskeleton
Deafness
Disease mutation
DNA damage
DNA repair
DNA-binding
Dwarfism
Helicase
Host-virus interaction
Hydrolase
Ichthyosis
Iron
Iron-sulfur
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Polymorphism
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Xeroderma pigmentosum
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:111622] Gopinathrao, G, 2004-03-01 18:40:00
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:2587579] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:6348050] Croft, D
[InstanceEdit:6379983] Croft, D
[InstanceEdit:6413044] Croft, D
[InstanceEdit:6446105] Croft, D
[InstanceEdit:6479166] Croft, D
[InstanceEdit:6512227] Croft, D
[InstanceEdit:6618954] Croft, D
[InstanceEdit:6636231] Croft, D
[InstanceEdit:6643142] Croft, D
[InstanceEdit:6650745] Croft, D
[InstanceEdit:6682804] Croft, D
[InstanceEdit:6698332] Croft, D
nameERCC2
otherIdentifierXM_005258639
X52221_at
A_24_P401990
16873268
AAM45142
LRG_461
uc002pbj.2
K7EIT8
3865335
NM_000400
AAI08256
PF06733
XP_005258696
3865331
3865323
EntrezGene:2068
AAI10524
3865309
63062_at
3865340
8037537
992_at
ENSG00000104884
8413672
3865311
UPI0000139012
HGNC:3434
CH471126
235399_at
3865333
IPR014013
PF06777
X52222
BC108255
NP_000391
Hs.99987.0.S1_3p_at
AY092780
AAP35529
MIM:126340
MIM:610756
11754536_a_at
ENSP00000431229
ENSP00000375809
3865332
OTTHUMP00000045860
ERCC2-001
X52221
MIM:278730
Hs.487294
Hs.663234
IPR006554
IPR006555
BT006883
3865326
MIM:601675
SM00491
SM00488
PH_hs_0005591
41095_at
IPR013020
11735285_x_at
0000130577
3865308
3865317
3865302
A8MX75
HPA038057
3865320
CAB005375
IPR010614
3865327
BC110523
EAW57341
213468_at
ENST00000391945
IPR027417
3865336
IPR001945
CAA36464
3865312
2068
3865334
CAA36463
3865303
ENST00000485403
ERCC2
L47234
3865307
32396_f_at
3865330
3865314
11750082_a_at
3865328
32397_r_at
AAL48323
3865341
3865329
3865318
PR00852
CCDS33049
2184031
3865313
LRG_461t1
GE59772
Hs.184329.0.S1_3p_at
3865339
ILMN_1815859
A_23_P130488
IPR010643
OTTHUMP00000267449
ERCC2-006
uc002pbl.5
3865337
NP_001124339
3865322
CCDS46112
NM_001130867
3865338
UPI000006D9DE
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6701285] KEGG Gene:2068 excision repair cross-complementation group 2 [Homo sapiens]
[ReferenceDNASequence:6353085] ENSEMBL:ENSG00000104884 [Homo sapiens]
[ReferenceDNASequence:6385003] NCBI Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6418591] BioGPS Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6451652] CTD Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6484713] dbSNP Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6639315] OMIM:278730 [Homo sapiens]
[ReferenceDNASequence:6639316] OMIM:601675 [Homo sapiens]
[ReferenceDNASequence:6639317] OMIM:610756 [Homo sapiens]
[ReferenceDNASequence:6639318] OMIM:126340 [Homo sapiens]
[ReferenceDNASequence:6722082] Orphanet:15989 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6689667] RefSeq:NM_000400
secondaryIdentifierERCC2_HUMAN
Q2TB78
Q2YDY2
Q7KZU6
Q8N721
sequenceLength760
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:67443] ERCC2 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:2564770] ERCC2 [cytosol] [Homo sapiens]
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