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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:67444
_displayNameUniProt:P18074 ERCC2
_timestamp2014-05-28 17:18:04
checksum746C0888CDF2E331
commentCATALYTIC ACTIVITY ATP + H(2)O = ADP + phosphate.SIMILARITY Belongs to the helicase family. RAD3/XPD subfamily.SIMILARITY Contains 1 helicase ATP-binding domain.
crossReference[DatabaseIdentifier:6442023] GeneCards:P18074
[DatabaseIdentifier:6456336] UCSC human:P18074
[DatabaseIdentifier:6466824] RefSeq:NP_000391
descriptionrecommendedName: TFIIH basal transcription factor complex helicase XPD subunit ecNumber3.6.4.12/ecNumber alternativeName: Basic transcription factor 2 80 kDa subunit shortName:BTF2 p80 alternativeName: CXPD alternativeName: DNA excision repair protein ERCC-2 alternativeName: DNA repair protein complementing XP-D cells alternativeName: TFIIH basal transcription factor complex 80 kDa subunit shortName:TFIIH 80 kDa subunit shortName:TFIIH p80 alternativeName: Xeroderma pigmentosum group D-complementing protein
geneNameERCC2
XPD
XPDC
identifierP18074
isSequenceChangedFALSE
keyword4Fe-4S
Alternative splicing
ATP-binding
Cataract
Chromosome partition
Cockayne syndrome
Complete proteome
Cytoplasm
Cytoskeleton
Deafness
Disease mutation
DNA damage
DNA repair
DNA-binding
Dwarfism
Helicase
Host-virus interaction
Hydrolase
Ichthyosis
Iron
Iron-sulfur
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Polymorphism
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Xeroderma pigmentosum
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:111622] Gopinathrao, G, 2004-03-01 18:40:00
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:2587579] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:6281038] Croft, D
[InstanceEdit:6311957] Croft, D
[InstanceEdit:6343996] Croft, D
[InstanceEdit:6376035] Croft, D
[InstanceEdit:6408074] Croft, D
[InstanceEdit:6440113] Croft, D
[InstanceEdit:6447579] Croft, D
[InstanceEdit:6454426] Croft, D
[InstanceEdit:6461892] Croft, D
[InstanceEdit:6492909] Croft, D
[InstanceEdit:6508136] Croft, D
nameERCC2
otherIdentifierENSG00000104884
ENST00000391945
ENSP00000375809
ENST00000221481
ENSP00000221481
992_at
213468_at
239853_at
235399_at
32397_r_at
41095_at
32396_f_at
63062_at
80680_at
X52221_at
Hs.184329.0.S1_3p_at
Hs.99987.0.S1_3p_at
Hs.184329.1.A1_3p_at
A_14_P135808
A_23_P130488
A_24_P401990
A_23_P130485
CCDS33049
GE59772
BC110523
X52221
X52222
L47234
AY092780
BC108255
BC110522
BT006883
EntrezGene:2068
GI_40068510-S
GI_29501806-I
ILMN_21902
ILMN_5243
IPI00029728
IPI00642906
IPI00745781
IPI00442420
MIM:126340
MIM:278730
MIM:601675
MIM:610756
OTTHUMP00000045861
OTTHUMP00000045862
OTTHUMT00000109627
OTTHUMT00000109628
AAI10524
CAA36463
CAA36464
AAL48323
AAM45142
AAI08256
AAI10523
AAP35529
NM_000400
NP_000391
OTTHUMT00000109626
Q2TB78
P18074
Q2TB79
Q7KZU6
Q2TB78_HUMAN
ERCC2_HUMAN
Q2TB79_HUMAN
Q7KZU6_HUMAN
IPR002464
IPR001945
IPR010614
IPR010643
IPR014013
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:6511072] KEGG Gene:2068 excision repair cross-complementation group 2 [Homo sapiens]
[ReferenceDNASequence:6286025] ENSEMBL:ENSG00000104884 [Homo sapiens]
[ReferenceDNASequence:6316920] NCBI Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6349439] BioGPS Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6381478] CTD Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6413517] dbSNP Gene:2068 [Homo sapiens]
[ReferenceDNASequence:6450642] OMIM:278730 [Homo sapiens]
[ReferenceDNASequence:6450643] OMIM:601675 [Homo sapiens]
[ReferenceDNASequence:6450644] OMIM:610756 [Homo sapiens]
[ReferenceDNASequence:6450645] OMIM:126340 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:6499648] RefSeq:NM_000400
secondaryIdentifierERCC2_HUMAN
Q2TB78
Q2YDY2
Q7KZU6
Q8N721
sequenceLength760
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:67443] ERCC2 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:2564770] ERCC2 [cytosol] [Homo sapiens]
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