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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P43403
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein kinase ZAP-70 ecNumber2.7.10.2/ecNumber alternativeName: 70 kDa zeta-chain associated protein alternativeName: Syk-related tyrosine kinase
Links to corresponding entries in other databasesBioGPS Gene:7535
Brenda:2.7.10.2
CTD Gene:7535
DOCK Blaster:1M61
DOCK Blaster:1U59
EC:2.7.10.2
ENSEMBL:ENSG00000115085
GeneCards:P43403
HapMap:NM_001079
IntEnz:2.7.10.2
KEGG Gene:7535
NCBI Gene:7535
OMIM:176947
Orphanet:15738
PRO:P43403
Protein Data Bank:1M61
Protein Data Bank:1U59
RefSeq:NM_001079
RefSeq:NP_001070
RefSeq:NP_997402
UCSC human:P43403
UniProt:P43403
dbSNP Gene:7535
Other identifiers related to this sequenceZAP70_HUMAN, A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6, IPR012234, XP_006712792, 3ZNI, AAH53878, PF07714, 2495217, AK303341, SM00219, 1423621, Hs.234569, AC016699, SM00220, HPA003134, ZAP70, 214032_at, 2495190, LRG_126t1, IPR001245, LRG_126, HGNC:12858, 4K2R, 0004810563, 2495212, 2495225, ENSP00000264972, 2495208, 2495197, 2495199, 2495222, IPR000719, PR00401, 2Y1N, 2495224, 2495227, ZAP70-001, 8043725, SM00252, L05148_at, PF00017, ENSG00000115085, 2495219, A_24_P169234, 4A4C, ILMN_1804104, IPR002290, 1M61, EntrezGene:7535, XP_005264072, Hs.234569.0.S1_3p_x_at, IPR011009, 2495210, 1498_at, UPI000013C370, 1555613_a_at, BC053878, B4E0E2, 2CBL, ILMN_1719756, NM_001079, 4A4B, BAC43747, AAH39039, 2495220, 2OQ1, AB083211, OTTHUMP00000203013, 2OZO, 11728780_a_at, 1FBV, 1U59, XP_006712791, 2495226, 2495188, AAX93187, PH_hs_0027314, ENST00000451498, CCDS33254, BC039039, 11728779_a_at, CAB002625, NP_001070, PF00069, XM_005264015, 2495218, MIM:269840, GE80046, ENSP00000400475, A_23_P39682, ENST00000264972, MIM:176947, uc002syd.1, 2495205, BAG64404, Hs2.234569.2.S1_3p_s_at, 7535, 2495207, IPR000980, PR00109, L05148, Hs.234569.0.S1_3p_at, IPR020635, 16883232, XM_006712729, UPI00000743CC, OTTHUMP00000216626, ILMN_1674838, NP_997402, NM_207519, ZAP70-008, CCDS33255, uc002syf.1
Molecules with this sequencep-Y315,Y493-ZAP70 [cytosol] UKENBCdOORHPGPPURRDD
p-Y493-ZAP70 [cytosol] UKENBCdOORHPGPPURRDD
ZAP70 [cytosol] UKENBCdOORHPGPPURRDD
SH2 domain
SH2 domain
SH2 domain
SH2 domain
Component ofActivated ZAP-70 [plasma membrane]
phospho tyrosine ZAP-70 [plasma membrane]
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]
Represented by generalisation(s)SYK/LCK/ZAP-70 [cytosol]
Processes where molecules and complexes with this sequence are involved

Immune System

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 493
O4'-phospho-L-tyrosine at 315
DomainsSH2 domain
SH2 domain
SH2 domain
SH2 domain
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