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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
IdentifierUniProt:P43403
DatabaseUniProt
SpeciesHomo sapiens
DescriptionrecommendedName: Tyrosine-protein kinase ZAP-70 ecNumber2.7.10.2/ecNumber alternativeName: 70 kDa zeta-chain associated protein alternativeName: Syk-related tyrosine kinase
Links to corresponding entries in other databasesBioGPS Gene:7535
Brenda:2.7.10.2
CTD Gene:7535
DOCK Blaster:1M61
DOCK Blaster:1U59
EC:2.7.10.2
ENSEMBL:ENSG00000115085
GeneCards:P43403
HapMap:NM_001079
IntEnz:2.7.10.2
KEGG Gene:7535
NCBI Gene:7535
OMIM:176947
Protein Data Bank:1M61
Protein Data Bank:1U59
RefSeq:NM_001079
RefSeq:NP_001070
RefSeq:NP_997402
UCSC human:P43403
UniProt:P43403
dbSNP Gene:7535
Other identifiers related to this sequenceZAP70_HUMAN, A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6, ENSG00000115085, ENST00000264972, ENSP00000264972, 1498_at, 1555613_a_at, 214032_at, L05148_at, Hs.234569.0.S1_3p_x_at, Hs2.234569.2.S1_3p_s_at, Hs.234569.0.S1_3p_at, A_23_P39682, A_24_P169234, CCDS33254, CCDS33255, GE80046, AB083211, BC039039, AC016699, L05148, BC053878, EntrezGene:7535, GI_31455610-S, ILMN_29912, IPI00329789, IPI00410185, IPI00783674, MIM:176947, 1M61, 1U59, BAC43747, AAH39039, AAX93187, AAH53878, NM_001079, NM_207519, NP_997402, NP_001070, Q8IXD6, Q9UBS6, Q6PIA4, P43403, Q8IXD6_HUMAN, Q9UBS6_HUMAN, Q6PIA4_HUMAN, ZAP70_HUMAN, IPR000719, IPR008266, IPR000980, IPR001245
Molecules with this sequencep-Y315,Y493-ZAP70 [cytosol] UKENBCdORHGURRPPDD
p-Y493-ZAP70 [cytosol] UKENBCdORHGURRPPDD
ZAP70 [cytosol] UKENBCdORHGURRPPDD
SH2 domain
SH2 domain
SH2 domain
SH2 domain
Component ofActivated ZAP-70 [plasma membrane]
phospho tyrosine ZAP-70 [plasma membrane]
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]
Represented by generalisation(s)SYK/LCK/ZAP-70 [cytosol]
Processes where molecules and complexes with this sequence are involved

Immune System

Modifications in molecules with this sequenceO4'-phospho-L-tyrosine at 493
O4'-phospho-L-tyrosine at 315
DomainsSH2 domain
SH2 domain
SH2 domain
SH2 domain
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