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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameDavey
First nameMegan J
InitialsMJ
AffiliationUniversity of Western Ontario
Author of summation(s)
Although, DNA replication occurs in the S phase of the cell ...
Studies in the past decade have suggested that the basic mec...
Author of entries
Activation of the pre-replicative complex [Homo sapiens]
Assembly of the ORC complex at the origin of replication [Homo sapiens]
Assembly of the pre-replicative complex [Homo sapiens]
Cdc45 associates with the pre-replicative complex at the origin [Homo sapiens]
CDC6 association with ORC:origin complexes mediated by MCM8 [Homo sapiens]
CDC6 association with the ORC:origin complex [Homo sapiens]
CDC6 protein is synthesized under the control of E2F transcription factors [Homo sapiens]
CDK and DDK associate with the Mcm10:pre-replicative complex [Homo sapiens]
CDT1 association with the CDC6:ORC:origin complex [Homo sapiens]
Cdt1 is displaced from the pre-replicative complex. [Homo sapiens]
DNA polymerase alpha:primase binds at the origin [Homo sapiens]
DNA polymerase epsilon binds at the origin [Homo sapiens]
DNA Replication [Homo sapiens]
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin [Homo sapiens]
DNA replication initiation [Homo sapiens]
DNA Replication Pre-Initiation [Homo sapiens]
Free CDT1 associates with CDC6:ORC:origin complexes [Homo sapiens]
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 [Homo sapiens]
Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) [Homo sapiens]
Mcm2-7 is phosphorylated by DDK [Homo sapiens]
Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes [Homo sapiens]
Orc3 associates with Orc2 constitutively bound at origins of replication [Homo sapiens]
Orc4 associates with Orc5:Orc3:Orc2:origin complexes [Homo sapiens]
Orc5 associates with Orc3:Orc2:origin complexes [Homo sapiens]
Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes [Homo sapiens]
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 [Homo sapiens]
Ubiquitinated geminin is degraded by the proteasome [Homo sapiens]
Publication(s)
Kaplan, DL, Davey, MJ, O'Donnell, M Mcm4,6,7 uses a 'pump in ring' mechanism to unwind DNA by steric exclusion and actively translocate along a duplex 2003 J Biol Chem PubMed
Davey, MJ, O'Donnell, M Mechanisms of DNA replication. 2000 Curr Opin Chem Biol PubMed
Davey, MJ, Indiani, C, O'Donnell, M Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture 2003 J Biol Chem PubMed