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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
First nameMichael
AffiliationThe Rockefeller University
Author of summation(s)
A hallmark of the human cell cycle in normal somatic cells i...
Although, DNA replication occurs in the S phase of the cell ...
Studies in the past decade have suggested that the basic mec...
The replication of the genome and the subsequent segregation...
Author of entries
Activation of the pre-replicative complex [Homo sapiens]
Assembly of the ORC complex at the origin of replication [Homo sapiens]
Assembly of the pre-replicative complex [Homo sapiens]
Cdc45 associates with the pre-replicative complex at the origin [Homo sapiens]
CDC6 association with ORC:origin complexes mediated by MCM8 [Homo sapiens]
CDC6 association with the ORC:origin complex [Homo sapiens]
CDC6 protein is synthesized under the control of E2F transcription factors [Homo sapiens]
CDK and DDK associate with the Mcm10:pre-replicative complex [Homo sapiens]
CDT1 association with the CDC6:ORC:origin complex [Homo sapiens]
Cdt1 is displaced from the pre-replicative complex. [Homo sapiens]
Cell Cycle Checkpoints [Homo sapiens]
Cell Cycle, Mitotic [Homo sapiens]
Cyclin A/B1 associated events during G2/M transition [Homo sapiens]
Cyclin D associated events in G1 [Homo sapiens]
Cyclin E associated events during G1/S transition [Homo sapiens]
DNA polymerase alpha:primase binds at the origin [Homo sapiens]
DNA polymerase epsilon binds at the origin [Homo sapiens]
DNA Replication [Homo sapiens]
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin [Homo sapiens]
DNA replication initiation [Homo sapiens]
DNA Replication Pre-Initiation [Homo sapiens]
Free CDT1 associates with CDC6:ORC:origin complexes [Homo sapiens]
G1 Phase [Homo sapiens]
G1/S DNA Damage Checkpoints [Homo sapiens]
G1/S Transition [Homo sapiens]
G1/S-Specific Transcription [Homo sapiens]
G2 Phase [Homo sapiens]
G2/M Checkpoints [Homo sapiens]
G2/M DNA damage checkpoint [Homo sapiens]
G2/M DNA replication checkpoint [Homo sapiens]
G2/M Transition [Homo sapiens]
M/G1 Transition [Homo sapiens]
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 [Homo sapiens]
Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC) [Homo sapiens]
Mcm2-7 is phosphorylated by DDK [Homo sapiens]
Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes [Homo sapiens]
Orc3 associates with Orc2 constitutively bound at origins of replication [Homo sapiens]
Orc4 associates with Orc5:Orc3:Orc2:origin complexes [Homo sapiens]
Orc5 associates with Orc3:Orc2:origin complexes [Homo sapiens]
Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes [Homo sapiens]
Proteasome mediated degradation of Cyclin D1 [Homo sapiens]
Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm [Homo sapiens]
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 [Homo sapiens]
Ubiquitin-dependent degradation of Cyclin D [Homo sapiens]
Ubiquitin-dependent degradation of Cyclin D1 [Homo sapiens]
Ubiquitinated geminin is degraded by the proteasome [Homo sapiens]
Dean, FB, Lian, L, O'Donnell, M cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster 1998 Genomics PubMed
Kaplan, DL, Davey, MJ, O'Donnell, M Mcm4,6,7 uses a 'pump in ring' mechanism to unwind DNA by steric exclusion and actively translocate along a duplex 2003 J Biol Chem PubMed
Davey, MJ, O'Donnell, M Mechanisms of DNA replication. 2000 Curr Opin Chem Biol PubMed
Davey, MJ, Indiani, C, O'Donnell, M Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture 2003 J Biol Chem PubMed