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Pyruvate metabolism and TCA cycle Stable identifier REACT_1046.3 Authored Birney, E, D'Eustachio, P, Schmidt, EE, 2003-11-03 Your feedback Let us know what you think of this article (click here) These two pathways convert pyruvate (derived from glucose by glycolysis or from alanine by transamination) to acetyl-CoA, which in turn can be oxidized via the citric acid cycle. Preceding event(s) Glycolysis [Homo sapiens] Organism Homo sapiens Cellular compartment mitochondrion GO Equivalent event(s) in other organism(s) Pyruvate metabolism and TCA cycle [Mus musculus] Pyruvate metabolism and TCA cycle [Rattus norvegicus] Pyruvate metabolism and TCA cycle [Gallus gallus] Pyruvate metabolism and TCA cycle [Tetraodon nigroviridis] Pyruvate metabolism and TCA cycle [Drosophila melanogaster] Pyruvate metabolism and TCA cycle [Caenorhabditis elegans] Pyruvate metabolism and TCA cycle [Cryptococcus neoformans A/D] Pyruvate metabolism and TCA cycle [Saccharomyces cerevisiae] Pyruvate metabolism and TCA cycle [Neurospora crassa] Pyruvate metabolism and TCA cycle [Schizosaccharomyces pombe] Pyruvate metabolism and TCA cycle [Cyanidioschyzon merolae] Pyruvate metabolism and TCA cycle [Thalassiosira pseudonana] Pyruvate metabolism and TCA cycle [Arabidopsis thaliana] Pyruvate metabolism and TCA cycle [Oryza sativa] Pyruvate metabolism and TCA cycle [Entamoeba histolytica] Pyruvate metabolism and TCA cycle [Dictyostelium discoideum] Pyruvate metabolism and TCA cycle [Plasmodium falciparum] Pyruvate metabolism and TCA cycle [Sulfolobus solfataricus] Pyruvate metabolism and TCA cycle [Methanocaldococcus jannaschii] Pyruvate metabolism and TCA cycle [Escherichia coli] Pyruvate metabolism and TCA cycle [Synechococcus sp.] Pyruvate metabolism and TCA cycle [Mycobacterium tuberculosis] Participating molecules (S)-Lactate [cytosol] CCP (S)-Lactate [extracellular region] CCP (S)-Malate [mitochondrial matrix] CCP 2-(alpha-hydroxyethyl)-TPP [mitochondrial matrix] CCP 2-Oxoglutarate [mitochondrial matrix] CCP 3-carboxy-1-hydroxypropyl-TPP [mitochondrial matrix] CCP Acetyl-CoA [mitochondrial matrix] CC aconitase 2, mitochondrial [mitochondrial matrix] UKEGORHUR ADP [mitochondrial matrix] CCP alpha-ketoglutarate dehydrogenase E1 apoenzyme [mitochondrial matrix] UKEGORRHHURR ... List all 71 participating molecules