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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameMerrick
First nameWilliam C
InitialsWC
AffiliationCase Western University, Biochemistry Department
Author of summation(s)
Protein synthesis is accomplished through the process of tra...
Author of entries
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [Homo sapiens]
Cap-bound mRNA is activated by helicases [Homo sapiens]
Cap-dependent Translation Initiation [Homo sapiens]
eIF2:GTP is hydrolyzed, eIFs are released [Homo sapiens]
eIF4F binds to mRNP [Homo sapiens]
eIF5B:GTP is hydrolyzed and released [Homo sapiens]
Eukaryotic Translation Initiation [Homo sapiens]
Eukaryotic Translation Termination [Saccharomyces cerevisiae]
Eukaryotic Translation Termination [Homo sapiens]
Formation of translation initiation complexes containing mRNA that does not circularize [Homo sapiens]
GTP hydrolysis and joining of the 60S ribosomal subunit [Homo sapiens]
Ribosomal scanning [Homo sapiens]
Ribosomal scanning and start codon recognition [Homo sapiens]
Start codon recognition [Homo sapiens]
The 60S subunit joins the translation initiation complex [Homo sapiens]
Translation [Homo sapiens]
Translation initiation complex formation [Homo sapiens]
Publication(s)
Peterson, DT, Merrick, WC, Safer, B Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation. 1979 J Biol Chem PubMed
Safer, B, Adams, SL, Anderson, WF, Merrick, WC Binding of MET-TRNAf and GTP to homogeneous initiation factor MP. 1976 J Biol Chem PubMed
Carvalho, MD, Carvalho, JF, Merrick, WC Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes 1984 Arch Biochem Biophys PubMed
Merrick, WC, Dever, TE, Kinzy, TG, Conroy, SC, Cavallius, J, Owens, CL Characterization of protein synthesis factors from rabbit reticulocytes 1990 Biochim Biophys Acta PubMed
Dever, TE, Wei, CL, Benkowski, LA, Browning, K, Merrick, WC, Hershey, JW Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. 1994 J Biol Chem PubMed
Merrick, WC Eukaryotic protein synthesis: still a mystery 2010 J Biol Chem PubMed
Merrick, WC Mechanism and regulation of eukaryotic protein synthesis 1992 Microbiol Rev PubMed
Grifo, JA, Tahara, SM, Morgan, MA, Shatkin, AJ, Merrick, WC New initiation factor activity required for globin mRNA translation. 1983 J Biol Chem PubMed
Gupta, S, Roy, AL, Nag, MK, Kinzy, TG, MacMillan, S, Hileman, RE, Dever, TE, Wu, S, Merrick, WC, Hershey, JW New insights into an old problem: ternary complex (Met-tRNAf.eIF.GTP) formation in animal cells. 1990 Post-transcriptional control of gene expression. J.E. McCarty and M.F.Tuite (eds). New insights into an old problem: ternary complex (Met-tRNAf.eIF.GTP) formation in animal cells.
Hershey, JW, Merrick, WC Pathway and mechanism of initiation of protein synthesis. 2000 Translational Control of Gene Expression. (Sonenberg, Hershey and Mathews, eds.) Pathway and mechanism of initiation of protein synthesis.
Orton, KC, Ling, J, Waskiewicz, AJ, Cooper, JA, Merrick, WC, Korneeva, NL, Rhoads, RE, Sonenberg, N, Traugh, JA Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk 2004 J Biol Chem PubMed
Merrick, WC, Kemper, WM, Anderson, WF Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes. 1975 J Biol Chem PubMed
Yoder-Hill, J, Pause, A, Sonenberg, N, Merrick, WC The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. 1993 J Biol Chem PubMed
Merrick, WC, Nyborg, J The Protein Biosynthesis Elongation Cycle 2000 Translational Control of Gene Expression The Protein Biosynthesis Elongation Cycle