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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameTello-Ruiz
First nameMarcela
InitialsMK
AffiliationCold Spring Harbor Laboratory
Author of summation(s)
A single recent study indicates that HNF1-beta/vHNF/TCF2 is ...
A single recent study suggests that during embryonic pancrea...
Binding of FOXa2/HNF3-beta to the 5'-flanking regions of the...
Binding of Pdx1 to the 5'-flanking region of the IAPP gene w...
Binding of Pdx1 to the 5'-flanking region of the Insulin gen...
Binding of Pdx1 to the 5'-flanking region of the mouse Nkx6....
Double Fgf10/Hnf6 KO studies have shown that these two prote...
During embryogenesis, committed epithelial cells from the ea...
Expression of Hnf1-beta is markedly reduced in early pancrea...
Fgf10-/- embryos have markedly reduced Ptf1 mRNA expression ...
Hnf1a (Tcf1) has been shown to activate the Glut2 gene in ra...
Hnf1a (Tcf1) has been shown to activate the Liver-type pyruv...
HNF1a was shown to bind a 3'-region of the Foxa3 (Hnf3g) gen...
Hnf1a was shown to bind Hnf4g gene by chromatin immunoprecip...
Hnf1a was shown to bind the Hnf4a promoter by chromatin immu...
Human and mouse MafA/RIPE3b1 bind to the insulin promoter in...
In vitro binding of MafA to a conserved 5'-flanking region o...
Insulin was markedly reduced in one Pax6 mutant model (Sande...
IRS2 is required for AKT to phosphorylate FOXO1, which is th...
Lack of TCF2 disrupts early pancreas development. Specifical...
Mutational analysis of the same 5'-flanking region that MafA...
NeuroD1 binds to control sequences of the mouse GK gene in v...
NeuroD1 is not expressed in Ngn3 knock-out mice (Gradwohl et...
Ngn3 expression induces Nkx2.2 gene expression (Huang et al....
Nkx2.2 is essential for the generation of insulin producing ...
Notch receptor undergoes several proteolytic steps which res...
Pdx1 controls Lrh1 expression. Lrh1 and Pdx1 are co-expresse...
Studies in Hnf6/Onecut1 knock-out embryos showed that HNF6 i...
The kinase activity of Akt protein catalyzes the phosphoryla...
The Ngn3 gene is transcribed, its mRNA is translated, and th...
When Foxo1 is phosphorylated, it is transported out of the n...
Whether Pdx1 transactivates the glucokinase (GK) gene in viv...
Author of entries
'fgf10 [extracellular region]' positively regulates 'FGF10 activates Pdx1 expression in the developing early pancreatic bud'
'fgf10 [extracellular region]' positively regulates 'FGF10 activates Ptf1 expression in early pancreatic buds'
'foxo1 [nucleoplasm]' negatively regulates 'FOXa2/HNF3b transactivates Pdx1'
'foxo1 [nucleoplasm]' negatively regulates 'MafA transactivates Pdx1'
'foxo1 [nucleoplasm]' negatively regulates 'PAX6 transactivates Pdx1'
'hes1 [nucleoplasm]' negatively regulates 'Hnf6-dependent synthesis of Ngn3 protein during morphogenesis'
'hnf1-alpha/tcf1 [nucleoplasm]' positively regulates 'HNF1a regulates Foxa3'
'hnf1-alpha/tcf1 [nucleoplasm]' positively regulates 'HNF1a regulates Hnf4a'
'hnf1-alpha/tcf1 [nucleoplasm]' positively regulates 'HNF1a regulates Hnf4g'
'hnf1-alpha/tcf1 [nucleoplasm]' positively regulates 'HNF1a transactivates Glut2'
'hnf1-alpha/tcf1 [nucleoplasm]' positively regulates 'HNF1a transactivates Pklr'
'hnf1-beta [nucleoplasm]' positively regulates 'HNF1b transactivates Hnf6'
'hnf1-beta [nucleoplasm]' positively regulates 'HNF1b transactivates Ptf1a'
'hnf3-beta/foxa2 [nucleoplasm]' positively regulates 'FOXa2/HNF3b transactivates Pdx1'
'hnf6/onecut1 [nucleoplasm]' positively regulates 'HNF6 positively regulates Hnf1b expression'
'hnf6/onecut1 [nucleoplasm]' positively regulates 'HNF6 transactivates Onecut3 during early pancreas specification'
'hnf6/onecut1 [nucleoplasm]' positively regulates 'HNF6 transactivates Onecut3 during morphogenesis'
'hnf6/onecut1 [nucleoplasm]' positively regulates 'HNF6 transactivates Pdx1'
'hnf6/onecut1 [nucleoplasm]' positively regulates 'Hnf6-dependent synthesis of Ngn3 protein during morphogenesis'
'ipf1/pdx1 [nucleoplasm]' positively regulates 'PDX1 transactivates Iapp'
'ipf1/pdx1 [nucleoplasm]' positively regulates 'PDX1 transactivates Lrh1'
'ipf1/pdx1 [nucleoplasm]' positively regulates 'PDX1 transactivates Nkx6.1'
'ipf1/pdx1 [nucleoplasm]' positively regulates 'PDX1 transactivates the glucokinase gene'
'ipf1/pdx1 [nucleoplasm]' positively regulates 'PDX1 transactivates the Insulin gene'
'irs2 [cytosol]' positively regulates 'Akt phosphorylates Foxo1 in the presence of IRS2'
'MafA [nucleoplasm]' positively regulates 'MafA transactivates Pdx1'
'MafA [nucleoplasm]' positively regulates 'MafA transactivates the Insulin gene'
'neuroD1 [nucleoplasm]' positively regulates 'NeuroD1 transactivates the glucokinase gene'
'ngn3 [nucleoplasm]' positively regulates 'Ngn3 transactivates Ia1'
'ngn3 [nucleoplasm]' positively regulates 'Ngn3 transactivates NeuroD1'
'ngn3 [nucleoplasm]' positively regulates 'Ngn3 transactivates Nkx2.2'
'ngn3 [nucleoplasm]' positively regulates 'Ngn3 transactivates Pax4'
'nicd1 [nucleoplasm]' positively regulates 'RBP-Jkappa transactivates Hes1 in the presence of NICD'
'nkx2.2 [nucleoplasm]' positively regulates 'NKX2.2 transactivates the Insulin gene'
'pax6 [nucleoplasm]' positively regulates 'PAX6 transactivates Pdx1'
'pax6 [nucleoplasm]' positively regulates 'PAX6 transactivates the Insulin gene'
'rbp-Jkappa [nucleoplasm]' positively regulates 'RBP-Jkappa transactivates Hes1 in the presence of NICD'
/figures/Ferrer_networks_DEC06.jpg
Akt phosphorylates Foxo1 in the presence of IRS2 [Mus musculus]
Akt1 [nucleoplasm] UENNBBCCddRHPR
Early stage pancreatic precursor cells [Mus musculus]
Endocrine-committed (Ngn3+) progenitor cells [Mus musculus]
fgf10 [extracellular region] UENBCdRHPR
FGF10 activates Pdx1 expression in the developing early pancreatic bud [Mus musculus]
FGF10 activates Ptf1 expression in early pancreatic buds [Mus musculus]
FOXa2/HNF3b transactivates Pdx1 [Mus musculus]
foxo1 [nucleoplasm] UENBCdRHPR
FOXO1-mediated regulation of Pdx1 expression [Mus musculus]
glut2 [plasma membrane] UENBCdRHPR
Hes1 [nucleoplasm] UENBCdRHPR
hnf1-alpha/tcf1 [nucleoplasm] UENBCdRHPPPPPPPRDDDDDD
hnf1-beta [nucleoplasm] UENBCdRHPR
HNF1a regulates Foxa3 [Mus musculus]
HNF1a regulates Hnf4a [Mus musculus]
HNF1a regulates Hnf4g [Mus musculus]
HNF1a transactivates Glut2 [Mus musculus]
HNF1a transactivates Pklr [Mus musculus]
HNF1b transactivates Hnf6 [Mus musculus]
HNF1b transactivates Ptf1a [Mus musculus]
hnf3-beta/foxa2 [nucleoplasm] UENBCdRHPR
hnf3-gamma/foxa3 [cytosol] UENBCdRHPR
hnf4-alpha [cytosol] UENBCdPR
hnf4-gamma [cytosol] UENBCdRHPR
HNF6 positively regulates Hnf1b expression [Mus musculus]
HNF6 transactivates Onecut3 during early pancreas specification [Mus musculus]
HNF6 transactivates Onecut3 during morphogenesis [Mus musculus]
HNF6 transactivates Pdx1 [Mus musculus]
Hnf6-dependent synthesis of Ngn3 protein during morphogenesis [Mus musculus]
hnf6/onecut1 [nucleoplasm] UENBCdRHPPRD
ia1 [cytosol] UENBCdRHPR
iapp [cytosol] UENBCdRHPR
IAPP(1-828) [cytosol] UKENBCdORHPGPURD
Ins1 [cytosol] UENBCdRHPR
ipf1/pdx1 [cytosol] UENBCdRHPR
Irs2 [cytosol] UENBCdRHPR
Late stage (branching morphogenesis) pancreatic bud precursor cells [Mus musculus]
lrh1 [cytosol] UENBCdRHPPPRDD
MafA [nucleoplasm] UENBCdRHPR
MafA transactivates Pdx1 [Mus musculus]
MafA transactivates the Insulin gene [Mus musculus]
NEUROD1 [nucleoplasm] UKENBCdOOOORHPGUR
NeuroD1 [nucleoplasm] UENBCdRHPR
NeuroD1 transactivates the glucokinase gene [Mus musculus]
NEUROG3 [nucleoplasm] UKENBCdOOORHPGUR
ngn3 [cytosol] UENBCdRHPR
ngn3 [nucleoplasm] UENBCdRHPR
Ngn3 transactivates Ia1 [Mus musculus]
Ngn3 transactivates NeuroD1 [Mus musculus]
Ngn3 transactivates Nkx2.2 [Mus musculus]
Ngn3 transactivates Pax4 [Mus musculus]
nicd1 [nucleoplasm] UENBCdRHPPRD
NKX2-2 [nucleoplasm] UKENBCdORHPGUR
nkx2.2 [nucleoplasm] UENBCdRHPR
NKX2.2 transactivates the Insulin gene [Mus musculus]
nkx6.1 [cytosol] UENBCdRHPR
O-phospho-L-serine at 253
onecut3 [cytosol] UENBCdRHPR
Pax6 [nucleoplasm] UEP
PAX6 transactivates Pdx1 [Mus musculus]
PAX6 transactivates the Insulin gene [Mus musculus]
PDX1 transactivates Iapp [Mus musculus]
PDX1 transactivates Lrh1 [Mus musculus]
PDX1 transactivates Nkx6.1 [Mus musculus]
PDX1 transactivates the glucokinase gene [Mus musculus]
PDX1 transactivates the Insulin gene [Mus musculus]
phospho-foxo1 [cytosol] UENBCdRHPR
phospho-foxo1 [nucleoplasm] UENBCdRHPR
Phosphorylated Foxo1 is excluded from the nucleus [Mus musculus]
protein tyrosine kinase activity of phospho-Akt [nucleoplasm]
ptf1a [cytosol] UENBCdRHPR
ptf1a [nucleoplasm] UENBCdRHPR
rbp-Jkappa [nucleoplasm] UENBCdRHPR
RBP-Jkappa transactivates Hes1 in the presence of NICD [Mus musculus]
Regulation of beta-cell development [Homo sapiens]
Regulation of gene expression in beta cells [Mus musculus]