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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
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Author of summation(s)
Acetylation of the TAFI63 subunit of SL1 by PCAF stimulates ...
As inferred from mouse cell models, the Transcription termin...
As the active RNA Polymerase I complex leaves the promoter R...
Composed of Acetylated SL1, phosphorylated UBF-1 bound the r...
Dissociation of paused ternary complexes requires the Polyme...
During initiation the double-stranded DNA must be melted and...
Human SL1 does not bind to DNA itself, rather it is recruite...
Named the "Sal Box" as a Sal I restriction endonuclease site...
Phosphorylation of UBF-1, bound to the promoter, activates U...
Promoter clearance is one of the rate-limiting steps in Poly...
PTRF binds the quaternary complex and mediates the dissociat...
Termination of transcription by RNA polymerase I is a 4 ste...
The activity of the upstream binding factor (UBF-1) plays an...
The Polymerase I promoter escape complex/with the now comple...
The RNA polymerase I holoenzyme is a protein complex that co...
The rRNA genes are transcribed by RNA polymerase I, one of t...
Transcription by RNA Polymerase I, RNA Polymerase III and t...
UBF-1 binds directly to the CORE and UCE elements of the rib...
Upon transcription initiation it is thought that RRN3 is ina...
Author of entries
Acetylated SL1 [nucleoplasm]
Acetylation of SL1 [Homo sapiens]
Acetylayed SL1:PhosUBF-1:rDNA promoter [nucleoplasm]
Active RNA Polymerase I [nucleoplasm]
Assembly of RNA Polymerase I Holoenzyme (mouse) [Mus musculus]
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [Homo sapiens]
elongating pre-rRNA transcript [nucleoplasm]
Elongation of pre-rRNA transcript [Homo sapiens]
Formation of SL1 [Homo sapiens]
Loss of Rrn3 from RNA Polymerase I promoter escape complex [Homo sapiens]
nascent pre-rRNA transcript [nucleoplasm]
p194 [nucleoplasm] UENBCdRHPR
p67 [nucleoplasm]
Phosphorylated UBF-1:rDNA promoter [nucleoplasm]
Phosphorylation of UBF-1:rDNA Promoter [Homo sapiens]
Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box [Homo sapiens]
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box [Homo sapiens]
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm]
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter [Homo sapiens]
Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter [Homo sapiens]
RNA Polymerase I Chain Elongation [Homo sapiens]
RNA Polymerase I Holoenzyme [nucleoplasm]
RNA Polymerase I Holoenzyme [nucleoplasm]
RNA Polymerase I Promoter Clearance [Homo sapiens]
RNA Polymerase I Promoter Escape [Homo sapiens]
RNA Polymerase I promoter escape complex [nucleoplasm]
RNA Polymerase I Promoter Opening [Homo sapiens]
RNA Polymerase I Transcription [Homo sapiens]
RNA Polymerase I Transcription Initiation [Homo sapiens]
RNA Polymerase I Transcription Termination [Homo sapiens]
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm]
Sal Box [nucleoplasm] EN
TAF1B [nucleoplasm] UKENBCdORHPGUR
TAF1C [nucleoplasm] UKENBCdORHPGUR
TTF-I binds to the Sal Box [Homo sapiens]
TTF-I:Sal Box [nucleoplasm]
UBF-1 Binds rDNA Promoter [Homo sapiens]
UBF-1:rDNA Promoter [nucleoplasm]
Comai, L, Zomerdijk, JC, Beckmann, H, Zhou, S, Tjian, R Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. 1995 Science PubMed
Tuan, JC, Zhai, W, Comai, L Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation. 1999 Mol Cell Biol PubMed
Zhai, W, Comai, L Repression of RNA polymerase I transcription by the tumor suppressor p53. 2000 Mol Cell Biol PubMed
Li, B, Comai, L Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. 2001 J Biol Chem PubMed
Comai, L, Tanese, N, Tjian, R The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. 1992 Cell PubMed