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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameComai
First nameL
InitialsL
Author of summation(s)
Acetylation of the TAFI63 subunit of SL1 by PCAF stimulates ...
As inferred from mouse cell models, the Transcription termin...
As the active RNA Polymerase I complex leaves the promoter R...
Composed of Acetylated SL1, phosphorylated UBF-1 bound the r...
Dissociation of paused ternary complexes requires the Polyme...
During initiation the double-stranded DNA must be melted and...
Human SL1 does not bind to DNA itself, rather it is recruite...
Named the "Sal Box" as a Sal I restriction endonuclease site...
Phosphorylation of UBF-1, bound to the promoter, activates U...
Promoter clearance is one of the rate-limiting steps in Poly...
PTRF binds the quaternary complex and mediates the dissociat...
Termination of transcription by RNA polymerase I is a 4 ste...
The activity of the upstream binding factor (UBF-1) plays an...
The Polymerase I promoter escape complex/with the now comple...
The RNA polymerase I holoenzyme is a protein complex that co...
The rRNA genes are transcribed by RNA polymerase I, one of t...
Transcription by RNA Polymerase I, RNA Polymerase III and t...
UBF-1 binds directly to the CORE and UCE elements of the rib...
Upon transcription initiation it is thought that RRN3 is ina...
Author of entries
Acetylated SL1 [nucleoplasm]
Acetylation of SL1 [Homo sapiens]
Acetylayed SL1:PhosUBF-1:rDNA promoter [nucleoplasm]
Active RNA Polymerase I [nucleoplasm]
Assembly of RNA Polymerase I Holoenzyme (mouse) [Mus musculus]
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [Homo sapiens]
elongating pre-rRNA transcript [nucleoplasm]
Elongation of pre-rRNA transcript [Homo sapiens]
Formation of SL1 [Homo sapiens]
Loss of Rrn3 from RNA Polymerase I promoter escape complex [Homo sapiens]
nascent pre-rRNA transcript [nucleoplasm]
p194 [nucleoplasm] UENBCdRHR
p67 [nucleoplasm]
Phosphorylated UBF-1:rDNA promoter [nucleoplasm]
Phosphorylation of UBF-1:rDNA Promoter [Homo sapiens]
Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box [Homo sapiens]
PTRF [nucleoplasm] UKENBCdORHGUR
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box [Homo sapiens]
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm]
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter [Homo sapiens]
Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter [Homo sapiens]
RNA Polymerase I Chain Elongation [Homo sapiens]
RNA Polymerase I Holoenzyme [nucleoplasm]
RNA Polymerase I Holoenzyme [nucleoplasm]
RNA Polymerase I Promoter Clearance [Homo sapiens]
RNA Polymerase I Promoter Escape [Homo sapiens]
RNA Polymerase I promoter escape complex [nucleoplasm]
RNA Polymerase I Promoter Opening [Homo sapiens]
RNA Polymerase I Transcription [Homo sapiens]
RNA Polymerase I Transcription Initiation [Homo sapiens]
RNA Polymerase I Transcription Termination [Homo sapiens]
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm]
Sal Box [nucleoplasm] EN
TAF1B [nucleoplasm] UKENBCdORHGUR
TAF1C [nucleoplasm] UKENBCdORHGUR
TTF-I binds to the Sal Box [Homo sapiens]
TTF-I:Sal Box [nucleoplasm]
UBF-1 Binds rDNA Promoter [Homo sapiens]
UBF-1:rDNA Promoter [nucleoplasm]
Publication(s)
Comai, L, Zomerdijk, JC, Beckmann, H, Zhou, S, Tjian, R Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. 1995 Science PubMed
Tuan, JC, Zhai, W, Comai, L Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation. 1999 Mol Cell Biol PubMed
Zhai, W, Comai, L Repression of RNA polymerase I transcription by the tumor suppressor p53. 2000 Mol Cell Biol PubMed
Li, B, Comai, L Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. 2001 J Biol Chem PubMed
Comai, L, Tanese, N, Tjian, R The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. 1992 Cell PubMed