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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameHoeijmakers
First nameJan H J
InitialsJH
AffiliationErasmus Medical Center, Institute of Genetics
Author of summation(s)
DNA repair is a phenomenal multi-enzyme, multi-pathway syste...
NER was first described in the model organism E. coli in the...
Author of entries
3' incision of the lesioned strand of DNA in TC-NER [Homo sapiens]
3'- incision of DNA by XPG in GG-NER [Homo sapiens]
5' incision leading to excision of DNA fragment with lesion in TC-NER [Homo sapiens]
5'-incision of DNA by ERCC1-XPF in GG-NER [Homo sapiens]
Active Pol II complex with repaired DNA template:mRNA hybrid [nucleoplasm]
Assembly of repair proteins at the site of Pol II blockage [Homo sapiens]
Binding of ERCC1-XPF to preincision complex [Homo sapiens]
damaged DNA substrate [nucleoplasm]
damaged DNA substrate:nascent mRNA hybrid [nucleoplasm]
damaged DNA substrate:nascent mRNA hybrid with 3' incision [nucleoplasm]
damaged DNA substrate:nascent mRNA hybrid with dual incisions [nucleoplasm]
damaged DNA with 3' incision [nucleoplasm]
damaged DNA with open bubble structure [nucleoplasm]
Displacement of stalled Pol II from the lesion site [Homo sapiens]
DNA Damage Recognition in GG-NER [Homo sapiens]
DNA Repair [Homo sapiens]
Dual incision reaction in GG-NER [Homo sapiens]
Dual incision reaction in TC-NER [Homo sapiens]
Formation of active Pol II complex with lesioned DNA template [Homo sapiens]
Formation of incision complex in GG-NER [Homo sapiens]
Formation of open bubble structure in DNA by helicases [Homo sapiens]
Formation of transcription-coupled NER (TC-NER) repair complex [Homo sapiens]
Gap-filling DNA repair synthesis and ligation in GG-NER [Homo sapiens]
Gap-filling DNA repair synthesis and ligation in TC-NER [Homo sapiens]
Global Genomic NER (GG-NER) [Homo sapiens]
Incision complex with 3'-incised damaged DNA [nucleoplasm]
incision complex for GG-NER [nucleoplasm]
Ligation of newly synthesized repair patch to incised DNA in GG-NER [Homo sapiens]
Ligation of newly synthesized repair patch to incised DNA in TC-NER [Homo sapiens]
newly synthesized DNA fragment [nucleoplasm]
Nucleotide Excision Repair [Homo sapiens]
pre-incision complex in GG-NER [nucleoplasm]
pre-incision complex with open DNA bubble [nucleoplasm]
Recruitment of repair factors to form preincision complex [Homo sapiens]
Repair synthesis for gap-filling by DNA pol delta in TC-NER [Homo sapiens]
Repair synthesis for gap-filling by DNA pol epsilon in TC-NER [Homo sapiens]
Repair synthesis for gap-filling by DNA polymerase in TC-NER [Homo sapiens]
Repair synthesis of patch ~27-30 bases long by DNA Pol Delta [Homo sapiens]
Repair synthesis of patch ~27-30 bases long by DNA polymerase [Homo sapiens]
Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon [Homo sapiens]
repaired DNA template:nascent mRNA hybrid [nucleoplasm]
Repaired double-stranded DNA [nucleoplasm]
Resumption of transcription after TC-NER [Homo sapiens]
RNA Pol II is blocked by the lesion leading to reduced transcription [Homo sapiens]
Stalled Pol II complex with damaged DNA hybrid [nucleoplasm]
Stalled Pol II in TC-NER [nucleoplasm]
Transcription-coupled NER (TC-NER) [Homo sapiens]
XPC binds to HR23B forming a heterodimeric complex [Homo sapiens]
XPC:HR23B complex binds to damaged DNA site with lesion [Homo sapiens]
XPC:HR23B:damaged DNA complex [nucleoplasm]
Publication(s)
Volker, M, Moné, MJ, Karmakar, P, van Hoffen, A, Schul, W, Vermeulen, W, Hoeijmakers, JH, van Driel, R, van Zeeland, AA, Mullenders, LH Sequential assembly of the nucleotide excision repair factors in vivo. 2001 Mol Cell PubMed