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name	hydroxymethylglutaryl-CoA lyase activity
Accession	GO
Definition	Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.
Enzyme Classification (EC) number	4.1.3.4 4.1.3.4
Molecules/complexes with this activity
HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] HMGCL dimer (name copied from entity in Homo sapiens) [mitochondrial matrix] ... List all 14 items
Reactions catalysed by this activity
HMG CoA => acetoacetic acid+ acetyl CoA [Homo sapiens] HMG CoA => acetoacetic acid+ acetyl CoA [Canis familiaris] HMG CoA => acetoacetic acid+ acetyl CoA [Bos taurus] HMG CoA => acetoacetic acid+ acetyl CoA [Mus musculus] HMG CoA => acetoacetic acid+ acetyl CoA [Rattus norvegicus] HMG CoA => acetoacetic acid+ acetyl CoA [Gallus gallus] HMG CoA => acetoacetic acid+ acetyl CoA [Taeniopygia guttata] HMG CoA => acetoacetic acid+ acetyl CoA [Xenopus tropicalis] HMG CoA => acetoacetic acid+ acetyl CoA [Danio rerio] HMG CoA => acetoacetic acid+ acetyl CoA [Drosophila melanogaster] ... List all 14 items
Is a specialisation of activities
oxo-acid-lyase activity GO carbon-carbon lyase activity GO lyase activity GO catalytic activity GO molecular_function GO