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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
Details
SurnameHeldin
First nameCarl-Henrik
InitialsCH
AffiliationLudwig Institute for Cancer Research, Uppsala Branch
Author of summation(s)
The TGF-beta/BMP pathway incorporates several signaling path...
Publication(s)
Valgeirsdóttir, S, Paukku, K, Silvennoinen, O, Heldin, CH, Claesson-Welsh, L Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains 1998 Oncogene PubMed
Rosenzweig, BL, Imamura, T, Okadome, T, Cox, GN, Yamashita, H, ten Dijke, P, Heldin, CH, Miyazono, K Cloning and characterization of a human type II receptor for bone morphogenetic proteins 1995 Proc Natl Acad Sci U S A PubMed
Franzen, P, ten Dijke, P, Ichijo, H, Yamashita, H, Schulz, P, Heldin, CH, Miyazono, K Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor 1993 Cell PubMed
Moustakas, A, Heldin, CH Ecsit-ement on the crossroads of Toll and BMP signal transduction 2003 Genes Dev PubMed
Yokote, K, Margolis, B, Heldin, CH, Claesson-Welsh, L Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors 1996 J Biol Chem PubMed
Nakao, A, Afrakhte, M, Moren, A, Nakayama, T, Christian, JL, Heuchel, R, Itoh, S, Kawabata, M, Heldin, NE, Heldin, CH, ten Dijke, P Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling 1997 Nature PubMed
Blume-Jensen, P, Wernstedt, C, Heldin, CH, Rönnstrand, L Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells 1995 J Biol Chem PubMed
Rönnstrand, L, Mori, S, Arridsson, AK, Eriksson, A, Wernstedt, C, Hellman, U, Claesson-Welsh, L, Heldin, CH Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma 1992 EMBO J PubMed
Mori, S, Rönnstrand, L, Yokote, K, Engström, A, Courtneidge, SA, Claesson-Welsh, L, Heldin, CH Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases 1993 EMBO J PubMed
Yokote, K, Hellman, U, Ekman, S, Saito, Y, Rönnstrand, L, Saito, Y, Heldin, CH, Mori, S Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins 1998 Oncogene PubMed
Heldin, CH, Westermark, B Mechanism of action and in vivo role of platelet-derived growth factor 1999 Physiol Rev PubMed
Blume-Jensen, P, Rönnstrand, L, Gout, I, Waterfield, MD, Heldin, CH Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C 1994 J Biol Chem PubMed
Lönn, P, van der Heide, LP, Dahl, M, Hellman, U, Heldin, CH, Moustakas, A PARP-1 attenuates Smad-mediated transcription 2010 Mol Cell PubMed
Ostman, A, Thyberg, J, Westermark, B, Heldin, CH PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly 1992 J Cell Biol PubMed
Souchelnytskyi, S, ten Dijke, P, Miyazono, K, Heldin, CH Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses 1996 EMBO J PubMed
Souchelnytskyi, S, Tamaki, K, Engstrom, U, Wernstedt, C, ten Dijke, P, Heldin, CH Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling 1997 J Biol Chem PubMed
Souchelnytskyi, S, Ronnstrand, L, Heldin, CH, ten Dijke, P Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases 2001 Methods Mol Biol PubMed
Usuki, K, Saras, J, Waltenberger, J, Miyazono, K, Pierce, G, Thomason, A, Heldin, CH Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. 1992 Biochem Biophys Res Commun PubMed
Heldin, CH, Vanlandewijck, M, Moustakas, A Regulation of EMT by TGF? in cancer 2012 FEBS Lett. PubMed
Heldin, CH, Ostman, A, Rönnstrand, L Signal transduction via platelet-derived growth factor receptors 1998 Biochim Biophys Acta PubMed
Heldin, CH, ten Dijke, P SMAD destruction turns off signalling 1999 Nat Cell Biol PubMed
Nakao, A, Souchelnytskyi, S, Kawabata, M, Ishisaki, A, Oeda, E, Tamaki, K, Hanai, J, Heldin, CH, Miyazono, K, ten Dijke, P TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 1997 EMBO J PubMed
Kurisaki, A, Kose, S, Yoneda, Y, Heldin, CH, Moustakas, A Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner 2001 Mol Biol Cell PubMed
Arvidsson, AK, Rupp, E, Nånberg, E, Downward, J, Rönnstrand, L, Wennström, S, Schlessinger, J, Heldin, CH, Claesson-Welsh, L Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation 1994 Mol Cell Biol PubMed