Reactome: Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP

Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Homo sapiens]

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References
Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP
Stable identifier	REACT_1950.3
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At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'NADPH', and 1 molecule of 'Acetoacetyl-ACP' are present. At the end of this reaction, 1 molecule of 'beta-Hydroxybutyryl-ACP', and 1 molecule of 'NADP+' are present. This reaction takes place in the 'cytosol' and is mediated by the '3-oxoacyl-[acyl-carrier protein] reductase activity' of 'FAS dimer'.
Input (present at start of reaction)	Acetoacetyl-ACP [cytosol] H+ [cytosol] C C P NADPH [cytosol] C C P
Output (present at end of reaction)	beta-Hydroxybutyryl-ACP [cytosol] NADP+ [cytosol] C C P
Catalyst	FAS dimer [cytosol]
GO molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity GO
Preceding event(s)	Condensation of Malonyl-ACP and Acetate on different monomers of FAS dimer to Acetoacetyl-ACP [Homo sapiens]
Following event(s)	Dehydration of beta-Hydroxybutyryl-ACP to Crotonoyl-ACP [Homo sapiens]
Organism	Homo sapiens
Cellular compartment	cytosol GO
Jayakumar, A, Tai, MH, Huang, WY, al-Feel, W, Hsu, M, Abu-Elheiga, L, Chirala, SS, Wakil, SJ Human fatty acid synthase: properties and molecular cloning 1995 Proc Natl Acad Sci U S A PubMed
Equivalent event(s) in other organism(s)	Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Mus musculus] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Rattus norvegicus] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Gallus gallus] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Tetraodon nigroviridis] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Drosophila melanogaster] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Caenorhabditis elegans] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Cryptococcus neoformans A/D] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Saccharomyces cerevisiae] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Neurospora crassa] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Schizosaccharomyces pombe] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Thalassiosira pseudonana] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Arabidopsis thaliana] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Oryza sativa] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Dictyostelium discoideum] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Methanocaldococcus jannaschii] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Escherichia coli] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Synechococcus sp.] Reduction of Acetoacetyl-ACP to beta-Hydroxybutyryl-ACP [Mycobacterium tuberculosis]
Participating molecules
Acetoacetate [cytosol] C C P Fatty acid synthase [cytosol] U K E G O R H U R H+ [cytosol] C C P hydroxybutyrate [cytosol] C C P NADP+ [cytosol] C C P NADPH [cytosol] C C P

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