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Reactome (instancebrowser)
Reactome: A Curated Pathway Database
First nameJurg
AffiliationUniversity of Lausanne
Author of summation(s)
Apoptosis is a distinct form of cell death that is functiona...
Author of entries
Apoptosis [Homo sapiens]
Apoptotic execution phase [Homo sapiens]
Death Receptor Signalling [Homo sapiens]
Dimerization of procaspase-8 [Homo sapiens]
Extrinsic Pathway for Apoptosis [Homo sapiens]
FAS-mediated dimerization of procaspase-8 [Homo sapiens]
FASL binds FAS Receptor [Homo sapiens]
FasL/ CD95L signaling [Homo sapiens]
FasL:Fas binds FADD [Homo sapiens]
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10 [Homo sapiens]
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Homo sapiens]
Membrane-anchored TNF-alpha binds TNF-R1 [Homo sapiens]
TNF signaling [Homo sapiens]
TNF-mediated dimerization of procaspase-8 [Homo sapiens]
TNF:TNF-R1 binds TRADD, TRAF2 and RIP [Homo sapiens]
TRADD:TRAF2:RIP1 complex binds FADD [Homo sapiens]
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. [Homo sapiens]
TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 [Homo sapiens]
TRAIL signaling [Homo sapiens]
TRAIL Binds TRAIL-Receptor2 [Homo sapiens]
TRAIL-mediated dimerization of procaspase-8 [Homo sapiens]
TRAIL:TRAIL receptor-2 Trimer Binds FADD [Homo sapiens]
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10 [Homo sapiens]
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8 [Homo sapiens]
Trimerization of the FASL:FAS receptor complex [Homo sapiens]
Trimerization of TRAIL: TRAIL receptor-2 complex [Homo sapiens]
Mayor, A, Martinon, F, De Smedt, T, Pétrilli, V, Tschopp, J A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses 2007 Nat Immunol PubMed
Rebsamen, M, Heinz, LX, Meylan, E, Michallet, MC, Schroder, K, Hofmann, K, Vazquez, J, Benedict, CA, Tschopp, J DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB 2009 EMBO Rep PubMed
Martinon, F, Agostini, L, Meylan, E, Tschopp, J Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome 2004 Curr Biol PubMed
Micheau, O, Tschopp, J Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes 2003 Cell PubMed
Kummer, JA, Broekhuizen, R, Everett, H, Agostini, L, Kuijk, L, Martinon, F, Van Bruggen, R, Tschopp, J Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response 2007 J Histochem Cytochem PubMed
Irmler, M, Thome, M, Hahne, M, Schneider, P, Hofmann, K, Steiner, V, Bodmer, JL, Schröter, M, Burns, K, Mattmann, C, Rimoldi, D, French, LE, Tschopp, J Inhibition of death receptor signals by cellular FLIP 1997 Nature PubMed
Burns, K, Janssens, S, Brissoni, B, Olivos, N, Beyaert, R, Tschopp, J Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4 2003 J Exp Med PubMed
Dostert, C, Pétrilli, V, Van Bruggen, R, Steele, C, Mossman, BT, Tschopp, J Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica 2008 Science PubMed
Delaloye, J, Roger, T, Steiner-Tardivel, QG, Le Roy, D, Knaup Reymond, M, Akira, S, Petrilli, V, Gomez, CE, Perdiguero, B, Tschopp, J, Pantaleo, G, Esteban, M, Calandra, T Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome 2009 PLoS Pathog PubMed
Dostert, C, Meylan, E, Tschopp, J Intracellular pattern-recognition receptors 2008 Adv Drug Deliv Rev PubMed
Brissoni, B, Agostini, L, Kropf, M, Martinon, F, Swoboda, V, Lippens, S, Everett, H, Aebi, N, Janssens, S, Meylan, E, Felberbaum-Corti, M, Hirling, H, Gruenberg, J, Tschopp, J, Burns, K Intracellular trafficking of interleukin-1 receptor I requires Tollip 2006 Curr Biol PubMed
Martinon, F, Gaide, O, Pétrilli, V, Mayor, A, Tschopp, J NALP inflammasomes: a central role in innate immunity 2007 Semin Immunopathol PubMed
Martinon, F, Tschopp, J NLRs join TLRs as innate sensors of pathogens 2005 Trends Immunol PubMed
Meylan, E, Burns, K, Hofmann, K, Blancheteau, V, Martinon, F, Kelliher, M, Tschopp, J RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B 2004 Nat Immunol PubMed
Muruve, DA, Pétrilli, V, Zaiss, AK, White, LR, Clark, SA, Ross, PJ, Parks, RJ, Tschopp, J The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response 2008 Nature PubMed
Martinon, F, Burns, K, Tschopp, J The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta 2002 Mol Cell PubMed
Schroder, K, Tschopp, J The inflammasomes 2010 Cell PubMed
Schroder, K, Zhou, R, Tschopp, J The NLRP3 inflammasome: a sensor for metabolic danger? 2010 Science PubMed
Zhou, R, Tardivel, A, Thorens, B, Choi, I, Tschopp, J Thioredoxin-interacting protein links oxidative stress to inflammasome activation 2010 Nat Immunol PubMed
Burns, K, Clatworthy, J, Martin, L, Martinon, F, Plumpton, C, Maschera, B, Lewis, A, Ray, KP, Tschopp, J, Volpe, F Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor 2000 Nat Cell Biol PubMed
Michallet, MC, Meylan, E, Ermolaeva, MA, Vazquez, J, Rebsamen, M, Curran, J, Poeck, H, Bscheider, M, Hartmann, G, König, M, Kalinke, U, Pasparakis, M, Tschopp, J TRADD protein is an essential component of the RIG-like helicase antiviral pathway 2008 Immunity PubMed