Stabilisation of RAS:RAF by 14-3-3

Stabilisation of RAS:RAF by 14-3-3 [Homo sapiens]

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Stabilisation of RAS:RAF by 14-3-3
Stable identifier	REACT_996.4
Authored	Charalambous, M, 2005-01-07
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14-3-3 has been displaced from Ser259. 14-3-3 may now bind its higher affinity Ser621 (S2) site. This stabilises an 'open' Raf-1 conformation that is catalytically active, and bound to p21ras via both p21ras-binding domains, CRD and RBD.

Input (present at start of reaction)	RAS:RAF [plasma membrane] 14-3-3 protein beta/alpha [cytosol] U K E G B C d O R R H H U R R P P
Output (present at end of reaction)	RAS:RAF:14-3-3 [plasma membrane]
Preceding event(s)	Transient dissociation of 14-3-3 upon Ras binding [Homo sapiens]
Following event(s)	Stabilisation of RAF by further phosphorylation [Homo sapiens]
Organism	Homo sapiens
Cellular compartment	internal side of plasma membrane GO
Morrison, DK, Cutler, RE The complexity of Raf-1 regulation. 1997 Curr Opin Cell Biol PubMed
Equivalent event(s) in other organism(s)	Stabilisation of RAS:RAF by 14-3-3 [Canis familiaris] Stabilisation of RAS:RAF by 14-3-3 [Bos taurus] Stabilisation of RAS:RAF by 14-3-3 [Mus musculus] Stabilisation of RAS:RAF by 14-3-3 [Rattus norvegicus] Stabilisation of RAS:RAF by 14-3-3 [Gallus gallus] Stabilisation of RAS:RAF by 14-3-3 [Taeniopygia guttata] Stabilisation of RAS:RAF by 14-3-3 [Xenopus tropicalis] Stabilisation of RAS:RAF by 14-3-3 [Danio rerio] Stabilisation of RAS:RAF by 14-3-3 [Caenorhabditis elegans]
Participating molecules
14-3-3 protein beta/alpha [cytosol] U K E G B C d O R R H H U R R P P GTP [cytosol] C C p-Raf1(S259,S621) [cytosol] U K E G B C d O R H U R P P P P P p21 RAS [plasma membrane] p21/H-RAS-1 [plasma membrane] U K E G B C d O O O R H U R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P D D D D D D D D D D D D D D D p21/N-Ras [plasma membrane] U K E G B C d O O R H U R p21A (K-Ras 2A) [plasma membrane] U K E G B C d O O O O R H U R P P D D

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