Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex

Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Homo sapiens]

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Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
Stable identifier	REACT_6848.2
Authored	Luo, F, 2005-11-10
Reviewed	Gay, NJ, 2006-04-24
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At the beginning of this reaction, 2 molecules of 'ATP', and 1 molecule of 'IkBs:NFkB Complex' are present. At the end of this reaction, 1 molecule of 'NFkB Complex', 1 molecule of 'Phospho-NF-kappaB Inhibitor', and 2 molecules of 'ADP' are present. This reaction is mediated by the 'protein kinase activity' of 'Activated IKK Complex'.
Input (present at start of reaction)	IkBs:NFkB Complex [cytosol] ATP [cytosol] C C P x 2
Output (present at end of reaction)	NFkB Complex [cytosol] ADP [cytosol] C C P x 2 Phospho-NF-kappaB Inhibitor [cytosol]
Catalyst	Activated IKK Complex [cytosol]
GO molecular function	protein kinase activity GO
Preceding event(s)	TRAF6:Phosho-TAK1:Tab1:PhosphoTAB2 mediated phosphorylation of the IKK Complex [Homo sapiens] RIP1 phosphorylates IKKs [Homo sapiens] TRAF6:Phosho-TAK1:Tab1:PhosphoTAB2 mediated phosphorylation of the IKK Complex [Homo sapiens]
Following event(s)	Released NFkB complex is transported to the Nucleus [Homo sapiens]
Organism	Homo sapiens
Gil, J, Alcami, J, Esteban, M Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex 2000 Oncogene PubMed
Equivalent event(s) in other organism(s)	Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Mus musculus] Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Rattus norvegicus] Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Tetraodon nigroviridis] Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex [Drosophila melanogaster]
Participating molecules
ADP [cytosol] C C P ATP [cytosol] C C P IkBA [cytosol] U K E G O R H U R IkBB [cytosol] U K E G O R H U R IKKG [cytosol] U K E G O O O O O O O R R R H H H U R R R NF-kappaB inhibitor [cytosol] NFkB1 [cytosol] U K E G O U NFkB2 [cytosol] U K E G O R R H H U R NFkB3 [cytosol] U K E G O R H U R Nuclear factor NF-kappa-B [cytosol] ... List all 15 participating molecules

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