Reactome

Reactome - a curated knowledgebase of biological pathways

Apoptosis	Axon guidance	Biological oxidations	Botulinum neurotoxicity
Cell junction organization	Cell Cycle Checkpoints	Cell Cycle, Mitotic	DNA Repair
DNA Replication	Diabetes pathways	Electron Transport Chain	Gap junction trafficking and regulation
Gene Expression	Hemostasis	HIV Infection	Influenza Infection
Integration of energy metabolism	Integrin cell surface interactions	Metabolism of lipids and lipoproteins	Membrane Trafficking
Metabolism of amino acids and derivatives	Metabolism of carbohydrates	Metabolism of nitric oxide	Metabolism of nucleotides
Metabolism of polyamines	Metabolism of porphyrins	Metabolism of proteins	Metabolism of RNA
Metabolism of vitamins and cofactors	Muscle contraction	mRNA Processing	Myogenesis
Pyruvate metabolism and Citric Acid (TCA) cycle	Regulation of beta-cell development	Regulatory RNA pathways	Signaling by BMP
Signaling by EGFR	Signaling by FGFR	Signaling by GPCR	Signaling by PDGF
Signaling in Immune system	Signaling by Insulin receptor	Signalling by NGF	Signaling by Notch
Opioid Signalling	Signaling by Rho GTPases	Signaling by TGF beta	Signaling by VEGF
Signaling by Wnt	Synaptic Transmission	Telomere Maintenance	Transcription
Transmembrane transport of small molecules

About Reactome		News and Notes
REACTOME is a free, online, open-source, curated pathway database encompassing many areas of human biology. Information is authored by expert biological researchers, maintained by the Reactome editorial staff and cross-referenced to a wide range of standard biological databases. These include NCBI Entrez Gene, Ensembl and UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG Compound and ChEBI small molecule databases, PubMed, and GO. The curated human data are used to infer orthologous events in 22 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, two plants and E.coli. Tools for pathway analysis include Skypainter and Biomart. Pathway data can be exported in SBML and BioPAX formats. A description of Reactome has been published in Genome Biology and Nucleic Acids Research. Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway analysis and pathway visualization tools. Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements. Please take note of our disclaimer.		March 16, 2010 Version 32 Released Version 32 includes the new topic the role of CDO in Myogenesis. Topics revised and updated with new events and/or revisions to existing events in this release include: Synaptic Transmission (Activation of Kainate receptors upon glutamate binding), Signaling by insulin receptor (Energy dependent regulation of mTOR by LKB1-AMPK ), DNA repair (Fanconi Anemia Pathway), Toll Receptor Cascades (Toll Like Receptor 3(TLR3) cascade), Olfactory Signaling Pathway, Cell Cycle Pathways, metabolic pathways for Amino Acids, Carbohydrates, and Nucleotides, and the TCA cycle. P Katajisto, T Makela, and J Wu are our external authors in this release. T Huang, R Krauss, D Tukey, L Vosshall, and B Zheng are our external reviewers. As part of the HUPO Proteomics Standards Initiative (PSI), we now annotate modified residues of proteins using MOD terms, and provide listings of protein-protein interactions in PSI-MITAB format. Reactome data is now available in BioPAX level 3(release 1.0) and level 2 format. Reactome is now on Facebook, Twitter, and LinkedIn. January 15, 2010 Feedback Request - Target Species for Orthology Inference Reactome provides orthology-based pathway projections from human to other species. We are currently reviewing the list of target species. Please let us know if you would like to include a species that's not in the planned target species list. More...

About Reactome

News and Notes

REACTOME is a free, online, open-source, curated pathway database encompassing many areas of human biology. Information is authored by expert biological researchers, maintained by the Reactome editorial staff and cross-referenced to a wide range of standard biological databases.

These include NCBI Entrez Gene, Ensembl and UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG Compound and ChEBI small molecule databases, PubMed, and GO. The curated human data are used to infer orthologous events in 22 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, two plants and E.coli. Tools for pathway analysis include Skypainter and Biomart.

Pathway data can be exported in SBML and BioPAX formats.

A description of Reactome has been published in Genome Biology and Nucleic Acids Research.
Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway analysis and pathway visualization tools.

Click on contact to reach us, on editorial to contribute to Reactome content, and on subscribe to receive Reactome announcements.

Please take note of our disclaimer.

March 16, 2010 Version 32 Released
Version 32 includes the new topic the role of CDO in Myogenesis. Topics revised and updated with new events and/or revisions to existing events in this release include: Synaptic Transmission (Activation of Kainate receptors upon glutamate binding), Signaling by insulin receptor (Energy dependent regulation of mTOR by LKB1-AMPK ), DNA repair (Fanconi Anemia Pathway), Toll Receptor Cascades (Toll Like Receptor 3(TLR3) cascade), Olfactory Signaling Pathway, Cell Cycle Pathways, metabolic pathways for Amino Acids, Carbohydrates, and Nucleotides, and the TCA cycle.
P Katajisto, T Makela, and J Wu are our external authors in this release. T Huang, R Krauss, D Tukey, L Vosshall, and B Zheng are our external reviewers.
As part of the HUPO Proteomics Standards Initiative (PSI), we now annotate modified residues of proteins using MOD terms, and provide listings of protein-protein interactions in PSI-MITAB format.
Reactome data is now available in BioPAX level 3(release 1.0) and level 2 format.
Reactome is now on Facebook, Twitter, and LinkedIn.
January 15, 2010 Feedback Request - Target Species for Orthology Inference
Reactome provides orthology-based pathway projections from human to other species. We are currently reviewing the list of target species. Please let us know if you would like to include a species that's not in the planned target species list.
More...