Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:49595
_chainChangeLogpropeptide:1-2 added on Fri February 6 2015;chain:3-377 added on Fri February 6 2015
_displayNameUniProt:P68032 ACTC1
_timestamp2016-02-24 23:38:46
chainpropeptide:1-2
chain:3-377
checksumE5C10FA19730CAD2
commentFUNCTION Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.SUBUNIT Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.MISCELLANEOUS In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
crossReference[DatabaseIdentifier:9710514] GeneCards:P68032
[DatabaseIdentifier:9756320] PRO:P68032
[DatabaseIdentifier:9786901] RefSeq:NP_005150
[DatabaseIdentifier:9832294] UCSC human:P68032
descriptionrecommendedName: Actin, alpha cardiac muscle 1 alternativeName: Alpha-cardiac actin
geneNameACTC1
ACTC
identifierP68032
isSequenceChangedFALSE
keywordATP-binding
Atrial septal defect
Cardiomyopathy
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Isopeptide bond
Methylation
Muscle protein
Nucleotide-binding
Oxidation
Reference proteome
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5083144] Weiser, JD
[InstanceEdit:5263031] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:5691543] Weiser, JD
[InstanceEdit:6807888] Weiser, JD
[InstanceEdit:9585445] Croft, D
[InstanceEdit:9609708] Croft, D
[InstanceEdit:9633970] Croft, D
[InstanceEdit:9658232] Croft, D
[InstanceEdit:9682494] Croft, D
[InstanceEdit:9706561] Croft, D
[InstanceEdit:9745126] Croft, D
[InstanceEdit:9773795] Croft, D
[InstanceEdit:9810776] Croft, D
[InstanceEdit:9828341] Croft, D
[InstanceEdit:10995712] Croft, D
nameACTC1
otherIdentifier11720489_a_at
11720490_at
205132_at
39063_at
53330_at
70
A_23_P205894
A_24_P121535
A_33_P3236382
AAB59619
AAH09978
ACTC1
ACTC1-001
BC009978
CAB003761
CAB037330
CAG46594
CCDS10041
CR541795
ENSG00000159251
ENSP00000290378
ENST00000290378
EntrezGene:70
g10938011_3p_at
GE60487
HGNC:143
HPA041264
HPA041271
ILMN_1658660
IPR004000
IPR004001
IPR020902
J00070
J00071
J00072
J00073
J00073_at
LRG_388
LRG_388t1
MIM:102540
NM_005159
NP_005150
OTTHUMP00000160081
PF00022
PH_hs_0006487
PH_hs_0049153
PR00190
R-HSA-390522
R-HSA-397014
SM00268
uc001ziu.2
UPI0000003F15
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:11001609] KEGG Gene:ACTC1 [Homo sapiens]
[ReferenceDNASequence:9579892] Orphanet:15076 [Homo sapiens]
[ReferenceDNASequence:9592812] NCBI Gene:70 [Homo sapiens]
[ReferenceDNASequence:9619517] BioGPS Gene:70 [Homo sapiens]
[ReferenceDNASequence:9643779] CTD Gene:70 [Homo sapiens]
[ReferenceDNASequence:9668041] dbSNP Gene:70 [Homo sapiens]
[ReferenceDNASequence:9689711] ENSEMBL:ENSG00000159251 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:9822075] RefSeq:NM_005159
secondaryIdentifierACTC_HUMAN
P04270
sequenceLength377
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:390536] ACTC1 [cytosol] [Homo sapiens]