Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:49988
_chainChangeLogsignal peptide:1-33 added on Fri February 6 2015;chain:34-485 added on Fri February 6 2015;peptide:34-43 added on Fri February 6 2015;peptide:34-42 added on Fri February 6 2015;peptide:34-41 added on Fri February 6 2015;peptide:34-40 added on Fri February 6 2015;peptide:34-38 added on Fri February 6 2015;peptide:34-37 added on Fri February 6 2015;peptide:35-41 added on Fri February 6 2015;peptide:36-41 added on Fri February 6 2015
_displayNameUniProt:P01019 AGT
_timestamp2016-02-24 23:38:48
chainsignal peptide:1-33
chain:34-485
peptide:34-43
peptide:34-42
peptide:34-41
peptide:34-40
peptide:34-38
peptide:34-37
peptide:35-41
peptide:36-41
checksum5026C2DFB2DD236E
commentFUNCTION Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.FUNCTION Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.FUNCTION Angiotensin-3: stimulates aldosterone release.TISSUE SPECIFICITY Expressed by the liver and secreted in plasma.PTM The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
crossReference[DatabaseIdentifier:9707759] GeneCards:P01019
[DatabaseIdentifier:9717255] Protein Data Bank:3WOR
[DatabaseIdentifier:9717256] Protein Data Bank:4AA1
[DatabaseIdentifier:9717257] Protein Data Bank:3CK0
[DatabaseIdentifier:9717258] Protein Data Bank:3WOO
[DatabaseIdentifier:9717259] Protein Data Bank:2WXW
[DatabaseIdentifier:9717260] Protein Data Bank:2X0B
[DatabaseIdentifier:9717261] Protein Data Bank:1N9V
[DatabaseIdentifier:9717262] Protein Data Bank:2JP8
[DatabaseIdentifier:9717263] Protein Data Bank:1N9U
[DatabaseIdentifier:9717264] Protein Data Bank:4FYS
[DatabaseIdentifier:9717265] Protein Data Bank:4APH
[DatabaseIdentifier:9748937] PRO:P01019
[DatabaseIdentifier:9779989] RefSeq:NP_000020
[DatabaseIdentifier:9829539] UCSC human:P01019
[DatabaseIdentifier:9842224] DOCK Blaster:3WOR
[DatabaseIdentifier:9842225] DOCK Blaster:4AA1
[DatabaseIdentifier:9842226] DOCK Blaster:3CK0
[DatabaseIdentifier:9842227] DOCK Blaster:3WOO
[DatabaseIdentifier:9842228] DOCK Blaster:2WXW
[DatabaseIdentifier:9841490] DOCK Blaster:2X0B
[DatabaseIdentifier:9842229] DOCK Blaster:1N9V
[DatabaseIdentifier:9842230] DOCK Blaster:2JP8
[DatabaseIdentifier:9842231] DOCK Blaster:1N9U
[DatabaseIdentifier:9842232] DOCK Blaster:4FYS
[DatabaseIdentifier:9842233] DOCK Blaster:4APH
[DatabaseIdentifier:11011916] HMDB_protein:HMDBP02609
descriptionrecommendedName: Angiotensinogen alternativeName: Serpin A8 component recommendedName: Angiotensin-1 alternativeName: Angiotensin 1-10 alternativeName: Angiotensin I shortName:Ang I /component component recommendedName: Angiotensin-2 alternativeName: Angiotensin 1-8 alternativeName: Angiotensin II shortName:Ang II /component component recommendedName: Angiotensin-3 alternativeName: Angiotensin 2-8 alternativeName: Angiotensin III shortName:Ang III alternativeName: Des-Asp[1]-angiotensin II /component component recommendedName: Angiotensin-4 alternativeName: Angiotensin 3-8 alternativeName: Angiotensin IV shortName:Ang IV /component component recommendedName: Angiotensin 1-9 /component component recommendedName: Angiotensin 1-7 /component component recommendedName: Angiotensin 1-5 /component component recommendedName: Angiotensin 1-4 /component
geneNameAGT
SERPINA8
identifierP01019
isSequenceChangedFALSE
keyword3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal
Vasoactive
Vasoconstrictor
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3132113] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9585445] Croft, D
[InstanceEdit:9609708] Croft, D
[InstanceEdit:9633970] Croft, D
[InstanceEdit:9658232] Croft, D
[InstanceEdit:9682494] Croft, D
[InstanceEdit:9706561] Croft, D
[InstanceEdit:9716028] Croft, D
[InstanceEdit:9745126] Croft, D
[InstanceEdit:9773795] Croft, D
[InstanceEdit:9810776] Croft, D
[InstanceEdit:9828341] Croft, D
[InstanceEdit:9837589] Croft, D
[InstanceEdit:10995712] Croft, D
[InstanceEdit:11008109] Croft, D
nameAGT
otherIdentifier0004850273
11730726_s_at
11749833_s_at
183
1N9U
1N9V
202834_at
2JP8
2WXW
2X0B
3CK0
3WOO
3WOR
4AA1
4APH
4FYS
684_at
A_23_P115261
AAA51679
AAA51731
AAA52282
AAD14287
AAD14288
AAH11519
ACA05910
AGT
AGT-001
B0ZBE2
BC011519
CAA33385
CCDS1585
CH471098
EAW69918
EAW69919
ENSG00000135744
ENSP00000355627
ENST00000366667
EntrezGene:183
EU326304
g4557286_3p_at
GE80879
HGNC:333
HPA001557
ILMN_1813530
ILMN_1815242
IPR000227
IPR023795
IPR023796
K02215
K02215_at
M24686
M24687
M24688
M24689
M69110
MIM:106150
NM_000029
NP_000020
OTTHUMP00000035878
PF00079
PH_hs_0022023
PR00654
R-HSA-1430728
R-HSA-162582
R-HSA-1989781
R-HSA-2022377
R-HSA-2980736
R-HSA-372790
R-HSA-373076
R-HSA-375276
R-HSA-388396
R-HSA-392499
R-HSA-400206
R-HSA-416476
R-HSA-418594
R-HSA-500792
R-HSA-535734
R-HSA-556833
R-HSA-881907
S78529
S78530
SM00093
uc001hty.6
UPI0000125B13
X15324
X15325
X15326
X15327
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:10997671] KEGG Gene:AGT [Homo sapiens]
[ReferenceDNASequence:9578923] Orphanet:15475 [Homo sapiens]
[ReferenceDNASequence:9589353] NCBI Gene:183 [Homo sapiens]
[ReferenceDNASequence:9612517] BioGPS Gene:183 [Homo sapiens]
[ReferenceDNASequence:9636779] CTD Gene:183 [Homo sapiens]
[ReferenceDNASequence:9661041] dbSNP Gene:183 [Homo sapiens]
[ReferenceDNASequence:5649906] ENSEMBL:ENSG00000135744 AGT [Homo sapiens]
referenceTranscript[ReferenceRNASequence:9815203] RefSeq:NM_000029
secondaryIdentifierANGT_HUMAN
Q16358
Q16359
Q96F91
sequenceLength485
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:374187] AGT(34-41) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:1998759] AGT [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:2022346] AGT(34-43) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:2022348] AGT(34-42) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:2022351] AGT(34-40) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:2022354] AGT(35-41) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:2022355] AGT(36-41) [extracellular region] [Homo sapiens]