Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:50040
_displayNameUniProt:P01008 SERPINC1
_timestamp2013-09-04 22:30:37
checksum9A4E324F00683D9D
commentFUNCTION Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.SUBUNIT Forms protease inhibiting heterodimer with TMPRSS7.TISSUE SPECIFICITY Found in plasma.PTM Phosphorylation sites are present in the extracellular medium.SIMILARITY Belongs to the serpin family.
crossReference[DatabaseIdentifier:5332981] GeneCards:P01008
[DatabaseIdentifier:5346604] UCSC human:P01008
[DatabaseIdentifier:5359654] RefSeq:NP_000479
[DatabaseIdentifier:5396794] Protein Data Bank:1ANT
[DatabaseIdentifier:5396795] Protein Data Bank:1ATH
[DatabaseIdentifier:5396796] Protein Data Bank:1AZX
[DatabaseIdentifier:5396797] Protein Data Bank:1BR8
[DatabaseIdentifier:5396798] Protein Data Bank:1DZG
[DatabaseIdentifier:5396799] Protein Data Bank:1DZH
[DatabaseIdentifier:5396800] Protein Data Bank:1E03
[DatabaseIdentifier:5396801] Protein Data Bank:1E04
[DatabaseIdentifier:5396802] Protein Data Bank:1E05
[DatabaseIdentifier:5396803] Protein Data Bank:1JVQ
[DatabaseIdentifier:5396804] Protein Data Bank:1LK6
[DatabaseIdentifier:5396805] Protein Data Bank:1NQ9
[DatabaseIdentifier:5396806] Protein Data Bank:1OYH
[DatabaseIdentifier:5396807] Protein Data Bank:1R1L
[DatabaseIdentifier:5396808] Protein Data Bank:1SR5
[DatabaseIdentifier:5396809] Protein Data Bank:1TB6
[DatabaseIdentifier:5396810] Protein Data Bank:2ANT
[DatabaseIdentifier:5396811] Protein Data Bank:2B4X
[DatabaseIdentifier:5396812] Protein Data Bank:2BEH
[DatabaseIdentifier:5396813] Protein Data Bank:2GD4
[DatabaseIdentifier:5407238] DOCK Blaster:1ANT
[DatabaseIdentifier:5407239] DOCK Blaster:1ATH
[DatabaseIdentifier:5407240] DOCK Blaster:1AZX
[DatabaseIdentifier:5407241] DOCK Blaster:1BR8
[DatabaseIdentifier:5407242] DOCK Blaster:1DZG
[DatabaseIdentifier:5407243] DOCK Blaster:1DZH
[DatabaseIdentifier:5407244] DOCK Blaster:1E03
[DatabaseIdentifier:5407245] DOCK Blaster:1E04
[DatabaseIdentifier:5407246] DOCK Blaster:1E05
[DatabaseIdentifier:5407247] DOCK Blaster:1JVQ
[DatabaseIdentifier:5407248] DOCK Blaster:1LK6
[DatabaseIdentifier:5407249] DOCK Blaster:1NQ9
[DatabaseIdentifier:5407250] DOCK Blaster:1OYH
[DatabaseIdentifier:5407251] DOCK Blaster:1R1L
[DatabaseIdentifier:5406554] DOCK Blaster:1SR5
[DatabaseIdentifier:5406555] DOCK Blaster:1TB6
[DatabaseIdentifier:5407252] DOCK Blaster:2ANT
[DatabaseIdentifier:5407253] DOCK Blaster:2B4X
[DatabaseIdentifier:5407254] DOCK Blaster:2BEH
[DatabaseIdentifier:5406788] DOCK Blaster:2GD4
descriptionrecommendedName: Antithrombin-III shortName:ATIII alternativeName: Serpin C1
geneNameSERPINC1
AT3
PRO0309
identifierP01008
isSequenceChangedFALSE
keyword3D-structure
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Heparin-binding
Phosphoprotein
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thrombophilia
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:2587579] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5190312] Croft, D
[InstanceEdit:5217980] Croft, D
[InstanceEdit:5246504] Croft, D
[InstanceEdit:5275028] Croft, D
[InstanceEdit:5303552] Croft, D
[InstanceEdit:5332076] Croft, D
[InstanceEdit:5339167] Croft, D
[InstanceEdit:5345699] Croft, D
[InstanceEdit:5352790] Croft, D
[InstanceEdit:5380322] Croft, D
[InstanceEdit:5396147] Croft, D
[InstanceEdit:5405495] Croft, D
nameSERPINC1
otherIdentifierENSG00000117601
ENST00000367698
ENSP00000356671
210049_at
228216_at
1554491_a_at
37175_at
44524_at
80644_at
M21642_s_at
L00190_s_at
M21642_at
1554491_3p_a_at
g576553_3p_x_at
Hs2.75599.2.S1_3p_at
g576553_3p_at
Hs.29672.0.A1_3p_at
Hs2.75599.2.S1_3p_s_at
A_23_P114626
CCDS1313
GE60489
AB083704
AL136170
D29832
AB083707
AB083703
AB083701
X03203
M21645
X03204
M21642
M21636
M21637
M21638
M21640
M21641
M21644
M21643
L00190
L00185
L00186
AF130100
AF386078
X68793
BC022309
EntrezGene:462
GI_4502260-S
ILMN_18442
IPI00032179
IPI00844156
MIM:107300
MIM:188050
OTTHUMT00000090734
1ANT
1ATH
1AZX
1BR8
1DZG
1DZH
1E03
1E04
1E05
1JVQ
1LK6
1NQ9
1OYH
1R1L
1SR5
1TB6
2ANT
2B4X
2BEH
2GD4
BAC21175
CAI19423
BAA06212
BAC21176
BAC21174
BAC21173
CAA26951
AAA51795
CAA26952
AAA51796
AAA51794
AAB40025
AAG35525
AAK60337
CAA48690
AAA51793
AAH22309
NM_000488
NP_000479
Hs.75599
Hs.676282
Q8IZZ9
Q5TC78
Q7KZ97
Q9UC78
Q8IZZ8
Q8J000
Q8J001
Q9UE54
Q9UBW9
P01008
Q8TCE1
Q8IZZ9_HUMAN
Q5TC78_HUMAN
Q7KZ97_HUMAN
Q9UC78_HUMAN
Q8IZZ8_HUMAN
Q8J000_HUMAN
Q8J001_HUMAN
Q9UE54_HUMAN
Q9UBW9_HUMAN
ANT3_HUMAN
Q8TCE1_HUMAN
IPR000215
IPR000240
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:5196996] ENSEMBL:ENSG00000117601 [Homo sapiens]
[ReferenceDNASequence:5224630] NCBI Gene:462 [Homo sapiens]
[ReferenceDNASequence:5249418] BioGPS Gene:462 [Homo sapiens]
[ReferenceDNASequence:5277942] CTD Gene:462 [Homo sapiens]
[ReferenceDNASequence:5306466] dbSNP Gene:462 [Homo sapiens]
[ReferenceDNASequence:5344170] OMIM:107300 [Homo sapiens]
[ReferenceDNASequence:5339820] OMIM:188050 [Homo sapiens]
[ReferenceDNASequence:5395047] Orphanet:15272 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:5391208] RefSeq:NM_000488
secondaryIdentifierANT3_HUMAN
B2R6P0
P78439
P78447
Q13815
Q5TC78
Q7KZ43
Q7KZ97
Q9UC78
sequenceLength464
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:140792] SERPINC1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:140807] SERPINC1 [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:140814] SERPINC1(33-425) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:140815] SERPINC1(33-425) [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:140816] SERPINC1(426-464) [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:140817] SERPINC1(426-464) [extracellular region] [Homo sapiens]
(termProvider)[VertexSearchableTerm:5522356] CAA26952 [Homo sapiens]
[VertexSearchableTerm:5522399] BC022309 [Homo sapiens]
[VertexSearchableTerm:5522411] Q9UE54_HUMAN [Homo sapiens]
[VertexSearchableTerm:5522418] Q7KZ97 [Homo sapiens]
[VertexSearchableTerm:5522455] Q9UE54 [Homo sapiens]
[VertexSearchableTerm:5522505] Q9UC78_HUMAN [Homo sapiens]
[VertexSearchableTerm:5522545] P78439 [Homo sapiens]
[VertexSearchableTerm:5522554] Hs2.75599.2.S1_3p_at [Homo sapiens]
[VertexSearchableTerm:5522597] D29832 [Homo sapiens]
[VertexSearchableTerm:5522621] 1DZG [Homo sapiens]
List all 124 refering instances