Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:57208
_chainChangeLogchain:1-317 added on Sat February 7 2015
_displayNameUniProt:P25963 NFKBIA
_timestamp2016-02-24 23:38:50
chainchain:1-317
checksum088B313226786395
commentINDUCTION Induced in adherent monocytes.PTM Deubiquitinated by porcine reproductive and respiratory syndrome virus Nsp2 protein, which thereby interferes with NFKBIA degradation and impairs subsequent NF-kappa-B activation.
crossReference[DatabaseIdentifier:9584081] ZINC_target:P25963
[DatabaseIdentifier:9709119] GeneCards:P25963
[DatabaseIdentifier:9726241] Protein Data Bank:1IKN
[DatabaseIdentifier:9722350] Protein Data Bank:1NFI
[DatabaseIdentifier:9752011] PRO:P25963
[DatabaseIdentifier:9790196] RefSeq:NP_065390
[DatabaseIdentifier:9830899] UCSC human:P25963
[DatabaseIdentifier:9852687] DOCK Blaster:1IKN
[DatabaseIdentifier:9851085] DOCK Blaster:1NFI
descriptionrecommendedName: NF-kappa-B inhibitor alpha alternativeName: I-kappa-B-alpha shortName:IkB-alpha shortName:IkappaBalpha alternativeName: Major histocompatibility complex enhancer-binding protein MAD3
geneNameNFKBIA
IKBA
MAD3
NFKBI
identifierP25963
isSequenceChangedFALSE
keyword3D-structure
ANK repeat
Complete proteome
Cytoplasm
Disease mutation
Ectodermal dysplasia
Host-virus interaction
Hydroxylation
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9583234] Croft, D
[InstanceEdit:9585445] Croft, D
[InstanceEdit:9609708] Croft, D
[InstanceEdit:9633970] Croft, D
[InstanceEdit:9658232] Croft, D
[InstanceEdit:9682494] Croft, D
[InstanceEdit:9706561] Croft, D
[InstanceEdit:9716028] Croft, D
[InstanceEdit:9745126] Croft, D
[InstanceEdit:9773795] Croft, D
[InstanceEdit:9810776] Croft, D
[InstanceEdit:9828341] Croft, D
[InstanceEdit:9837589] Croft, D
[InstanceEdit:10995712] Croft, D
nameNFKBIA
otherIdentifier0001050280
11744000_a_at
11745878_x_at
11757894_x_at
1461_at
1IKN
1NFI
201502_s_at
4792
A_23_P106002
AAA16489
AAH02601
AAH04983
AAK51149
AAP35754
AAR29599
AJ249283
AJ249284
AJ249285
AJ249286
AJ249294
AJ249295
AK313421
AL133163
AY033600
AY496422
BAG36213
BC002601
BC004983
BT007091
CAB003815
CAB65556
CCDS9656
CH471078
EAW65875
ENSG00000100906
ENSP00000216797
ENST00000216797
EntrezGene:4792
GE82547
HGNC:7797
HPA029207
Hs.81328.0.S1_3p_a_at
IPR002110
IPR020683
LRG_89
LRG_89t1
M69043
M69043_at
MIM:164008
NFKBIA
NFKBIA-001
NM_020529
NP_065390
OTTHUMP00000178842
PF12796
PH_hs_0004662
PR01415
R-HSA-1168372
R-HSA-1169091
R-HSA-1280218
R-HSA-1606322
R-HSA-162582
R-HSA-1643685
R-HSA-166016
R-HSA-166054
R-HSA-166058
R-HSA-166166
R-HSA-166520
R-HSA-168138
R-HSA-168142
R-HSA-168164
R-HSA-168176
R-HSA-168179
R-HSA-168181
R-HSA-168188
R-HSA-168249
R-HSA-168256
R-HSA-168898
R-HSA-168928
R-HSA-1810476
R-HSA-181438
R-HSA-1834949
R-HSA-193639
R-HSA-193704
R-HSA-202403
R-HSA-202424
R-HSA-209560
R-HSA-2454202
R-HSA-2871837
R-HSA-445989
R-HSA-5260271
R-HSA-5602358
R-HSA-5603027
R-HSA-5603029
R-HSA-5607764
R-HSA-5621481
R-HSA-933542
R-HSA-937061
R-HSA-975138
R-HSA-975155
R-HSA-975871
R-HSA-983705
SM00248
uc001wtf.5
UPI000004F0A9
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:10999607] KEGG Gene:NFKBIA [Homo sapiens]
[ReferenceDNASequence:9579454] Orphanet:17400 [Homo sapiens]
[ReferenceDNASequence:9594445] NCBI Gene:4792 [Homo sapiens]
[ReferenceDNASequence:9615473] BioGPS Gene:4792 [Homo sapiens]
[ReferenceDNASequence:9639735] CTD Gene:4792 [Homo sapiens]
[ReferenceDNASequence:9663997] dbSNP Gene:4792 [Homo sapiens]
[ReferenceDNASequence:9691288] ENSEMBL:ENSG00000100906 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:9825318] RefSeq:NM_020529
secondaryIdentifierIKBA_HUMAN
B2R8L6
sequenceLength317
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:168151] NFKBIA [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:177677] p-S32,S36-NFKBIA [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:1168581] Ub-21,22-p-S32,S36-NFKBIA [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5228773] NFKBIA W11* [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5228774] NFKBIA E14* [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5228800] NFKBIA Q9* [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5228805] NFKBIA M37K [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5228846] NFKBIA S32I [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5607659] K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] [Homo sapiens]
(referenceSequence)[ModifiedResidue:177659] O-phospho-L-serine at 32
[ModifiedResidue:203803] O-phospho-L-serine at 32
[ModifiedResidue:203804] O-phospho-L-serine at 36
[ModifiedResidue:1168566] ubiquitinylated lysine at 21
[ModifiedResidue:1168569] ubiquitinylated lysine at 22
[FragmentDeletionModification:5228810] Deletion of residues 1 to 11
[FragmentDeletionModification:5228817] Deletion of residues 1 to 14
[FragmentDeletionModification:5228836] Deletion of residues 1 to 9
[ReplacedResidue:5228849] L-methionine 37 replaced with L-lysine
[ReplacedResidue:5228852] L-serine 32 replaced with L-isoleucine
List all 12 refering instances