Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:61664
_chainChangeLoginitiator methionine:1 added on Sat February 7 2015;chain:2-847 added on Sat February 7 2015
_displayNameUniProt:P06737 PYGL
_timestamp2016-02-24 23:39:16
chaininitiator methionine:1
chain:2-847
checksum74017E8125FB5735
commentFUNCTION Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.CATALYTIC ACTIVITY ((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.ENZYME REGULATION Activity of phosphorylase is controlled both by allosteric means (through the noncovalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.
crossReference[DatabaseIdentifier:9583599] ZINC_target:P06737
[DatabaseIdentifier:9708156] GeneCards:P06737
[DatabaseIdentifier:9737268] Protein Data Bank:3DDW
[DatabaseIdentifier:9737269] Protein Data Bank:3CEM
[DatabaseIdentifier:9737270] Protein Data Bank:3DD1
[DatabaseIdentifier:9737271] Protein Data Bank:3DDS
[DatabaseIdentifier:9737272] Protein Data Bank:2ZB2
[DatabaseIdentifier:9737273] Protein Data Bank:3CEH
[DatabaseIdentifier:9737274] Protein Data Bank:3CEJ
[DatabaseIdentifier:9737275] Protein Data Bank:1L7X
[DatabaseIdentifier:9737276] Protein Data Bank:1XOI
[DatabaseIdentifier:9737277] Protein Data Bank:2ATI
[DatabaseIdentifier:9737278] Protein Data Bank:2QLL
[DatabaseIdentifier:9737279] Protein Data Bank:1L5R
[DatabaseIdentifier:9737280] Protein Data Bank:1L5S
[DatabaseIdentifier:9737281] Protein Data Bank:1FA9
[DatabaseIdentifier:9737282] Protein Data Bank:1FC0
[DatabaseIdentifier:9737283] Protein Data Bank:1L5Q
[DatabaseIdentifier:9737284] Protein Data Bank:1EM6
[DatabaseIdentifier:9737285] Protein Data Bank:1EXV
[DatabaseIdentifier:9749523] PRO:P06737
[DatabaseIdentifier:9779192] RefSeq:NP_001157412
[DatabaseIdentifier:9779193] RefSeq:NP_002854
[DatabaseIdentifier:9829936] UCSC human:P06737
[DatabaseIdentifier:9846354] DOCK Blaster:3DDW
[DatabaseIdentifier:9846355] DOCK Blaster:3CEM
[DatabaseIdentifier:9846356] DOCK Blaster:3DD1
[DatabaseIdentifier:9846357] DOCK Blaster:3DDS
[DatabaseIdentifier:9846358] DOCK Blaster:2ZB2
[DatabaseIdentifier:9846359] DOCK Blaster:3CEH
[DatabaseIdentifier:9846360] DOCK Blaster:3CEJ
[DatabaseIdentifier:9846361] DOCK Blaster:1L7X
[DatabaseIdentifier:9846362] DOCK Blaster:1XOI
[DatabaseIdentifier:9846363] DOCK Blaster:2ATI
[DatabaseIdentifier:9846364] DOCK Blaster:2QLL
[DatabaseIdentifier:9846365] DOCK Blaster:1L5R
[DatabaseIdentifier:9846366] DOCK Blaster:1L5S
[DatabaseIdentifier:9846367] DOCK Blaster:1FA9
[DatabaseIdentifier:9846368] DOCK Blaster:1FC0
[DatabaseIdentifier:9846369] DOCK Blaster:1L5Q
[DatabaseIdentifier:9846370] DOCK Blaster:1EM6
[DatabaseIdentifier:9846371] DOCK Blaster:1EXV
[DatabaseIdentifier:11009898] HMDB_protein:HMDBP00370
descriptionrecommendedName: Glycogen phosphorylase, liver form ecNumber2.4.1.1/ecNumber
geneNamePYGL
identifierP06737
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Carbohydrate metabolism
Complete proteome
Disease mutation
Glycogen metabolism
Glycogen storage disease
Glycosyltransferase
Nucleotide-binding
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3132113] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5083144] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9583234] Croft, D
[InstanceEdit:9585445] Croft, D
[InstanceEdit:9609708] Croft, D
[InstanceEdit:9633970] Croft, D
[InstanceEdit:9658232] Croft, D
[InstanceEdit:9682494] Croft, D
[InstanceEdit:9706561] Croft, D
[InstanceEdit:9716028] Croft, D
[InstanceEdit:9745126] Croft, D
[InstanceEdit:9773795] Croft, D
[InstanceEdit:9810776] Croft, D
[InstanceEdit:9828341] Croft, D
[InstanceEdit:9837589] Croft, D
[InstanceEdit:10995712] Croft, D
[InstanceEdit:11008109] Croft, D
namePYGL
otherIdentifier0006760142
11719302_a_at
1EM6
1EXV
1FA9
1FC0
1L5Q
1L5R
1L5S
1L7X
1XOI
202990_at
2ATI
2QLL
2ZB2
37215_at
3CEH
3CEJ
3CEM
3DD1
3DDS
3DDW
5836
A_23_P48676
AAA35906
AAA52577
AAC17450
AAC18079
AAC23504
AAH09895
AAH82229
AAH95850
AAI10792
AF046785
AF046787
AF046788
AF046789
AF046790
AF046791
AF046792
AF046793
AF046794
AF046795
AF046796
AF046797
AF046798
AF066858
AK300580
AL358334
BAG62279
BC009895
BC082229
BC095850
BC110791
CAA75517
CCDS32080
CCDS53894
CH471078
EAW65685
ENSG00000100504
ENSP00000216392
ENSP00000443787
ENST00000216392
ENST00000544180
EntrezGene:5836
g4506352_3p_at
GE57832
HGNC:9725
HPA000962
HPA004119
Hs.282417
ILMN_1696187
IPR000811
IPR011833
M14636
M14636_at
M36807
MIM:613741
NM_001163940
NM_002863
NP_001157412
NP_002854
OTTHUMP00000233650
OTTHUMP00000233651
PF00343
PH_hs_0023452
PH_hs_0040703
PYGL
PYGL-001
PYGL-002
R-HSA-1430728
R-HSA-70221
R-HSA-70326
R-HSA-71387
uc001wyu.4
uc010tqq.3
UPI000011136E
UPI0001B1A4B7
Y15233
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:10998049] KEGG Gene:PYGL [Homo sapiens]
[ReferenceDNASequence:9579067] Orphanet:15176 [Homo sapiens]
[ReferenceDNASequence:9588955] NCBI Gene:5836 [Homo sapiens]
[ReferenceDNASequence:9613108] BioGPS Gene:5836 [Homo sapiens]
[ReferenceDNASequence:9637370] CTD Gene:5836 [Homo sapiens]
[ReferenceDNASequence:9661632] dbSNP Gene:5836 [Homo sapiens]
[ReferenceDNASequence:9685964] ENSEMBL:ENSG00000100504 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:9814405] RefSeq:NM_001163940
secondaryIdentifierPYGL_HUMAN
A6NDQ4
B4DUB7
F5H816
O60567
O60752
O60913
Q501V9
Q641R5
Q96G82
sequenceLength847
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:71580] PXLP-PYGL [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:71585] PXLP-p-S15-PYGL [cytosol] [Homo sapiens]
(referenceSequence)[ModifiedResidue:71584] O-phospho-L-serine at 15
[ModifiedResidue:453334] N6-pyridoxal phosphate-L-lysine at 661