Reactome: A Curated Pathway Database
Class:IdReferenceGeneProduct:68100
_chainChangeLogchain:1-619 added on Fri February 6 2015
_displayNameUniProt:P43403 ZAP70
_timestamp2016-02-24 23:39:31
chainchain:1-619
checksumD1E1A8EC66FA116F
commentSIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.SIMILARITY Contains 1 protein kinase domain.SIMILARITY Contains 2 SH2 domains.
crossReference[DatabaseIdentifier:9584423] ZINC_target:P43403
[DatabaseIdentifier:9709712] GeneCards:P43403
[DatabaseIdentifier:9735132] Protein Data Bank:1M61
[DatabaseIdentifier:9735133] Protein Data Bank:1U59
[DatabaseIdentifier:9735134] Protein Data Bank:2OZO
[DatabaseIdentifier:9735135] Protein Data Bank:4K2R
[DatabaseIdentifier:9735136] Protein Data Bank:4XZ0
[DatabaseIdentifier:9730083] Protein Data Bank:4XZ1
[DatabaseIdentifier:9730084] Protein Data Bank:2OQ1
[DatabaseIdentifier:9722042] Protein Data Bank:4A4C
[DatabaseIdentifier:9722043] Protein Data Bank:4A4B
[DatabaseIdentifier:9722050] Protein Data Bank:2Y1N
[DatabaseIdentifier:9722057] Protein Data Bank:2CBL
[DatabaseIdentifier:9722059] Protein Data Bank:1FBV
[DatabaseIdentifier:9719991] Protein Data Bank:3ZNI
[DatabaseIdentifier:9754080] PRO:P43403
[DatabaseIdentifier:9787494] RefSeq:NP_001070
[DatabaseIdentifier:9787495] RefSeq:NP_997402
[DatabaseIdentifier:9831492] UCSC human:P43403
[DatabaseIdentifier:9855488] DOCK Blaster:1M61
[DatabaseIdentifier:9855489] DOCK Blaster:1U59
[DatabaseIdentifier:9855490] DOCK Blaster:2OZO
[DatabaseIdentifier:9855491] DOCK Blaster:4K2R
[DatabaseIdentifier:9855492] DOCK Blaster:4XZ0
[DatabaseIdentifier:9851371] DOCK Blaster:4XZ1
[DatabaseIdentifier:9851372] DOCK Blaster:2OQ1
[DatabaseIdentifier:9851860] DOCK Blaster:4A4C
[DatabaseIdentifier:9851861] DOCK Blaster:4A4B
[DatabaseIdentifier:9851866] DOCK Blaster:2Y1N
[DatabaseIdentifier:9851872] DOCK Blaster:2CBL
[DatabaseIdentifier:9851874] DOCK Blaster:1FBV
[DatabaseIdentifier:9848367] DOCK Blaster:3ZNI
[DatabaseIdentifier:11010373] HMDB_protein:HMDBP01515
descriptionrecommendedName: Tyrosine-protein kinase ZAP-70 ecNumber2.7.10.2/ecNumber alternativeName: 70 kDa zeta-chain associated protein alternativeName: Syk-related tyrosine kinase
geneNameZAP70
SRK
identifierP43403
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Adaptive immunity
Alternative splicing
ATP-binding
Cell membrane
Complete proteome
Cytoplasm
Disease mutation
Immunity
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SCID
SH2 domain
Transferase
Tyrosine-protein kinase
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:2587579] Weiser, JD
[InstanceEdit:3445779] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9583234] Croft, D
[InstanceEdit:9585445] Croft, D
[InstanceEdit:9609708] Croft, D
[InstanceEdit:9633970] Croft, D
[InstanceEdit:9658232] Croft, D
[InstanceEdit:9682494] Croft, D
[InstanceEdit:9706561] Croft, D
[InstanceEdit:9716028] Croft, D
[InstanceEdit:9745126] Croft, D
[InstanceEdit:9773795] Croft, D
[InstanceEdit:9810776] Croft, D
[InstanceEdit:9828341] Croft, D
[InstanceEdit:9837589] Croft, D
[InstanceEdit:10995712] Croft, D
[InstanceEdit:11008109] Croft, D
nameZAP70
otherIdentifier0004810563
11728779_a_at
11728780_a_at
1498_at
1555613_a_at
1FBV
1M61
1U59
214032_at
2CBL
2OQ1
2OZO
2Y1N
3ZNI
4A4B
4A4C
4K2R
4XZ0
4XZ1
7535
A_23_P39682
AAH39039
AAH53878
AAX93187
AB083211
AC016699
BAC43747
BC039039
BC053878
CAB002625
CCDS33254
CCDS33255
ENSG00000115085
ENSP00000264972
ENSP00000400475
ENST00000264972
ENST00000451498
EntrezGene:7535
GE80046
HGNC:12858
HPA003134
Hs.234569
Hs.234569.0.S1_3p_at
Hs.234569.0.S1_3p_x_at
Hs2.234569.2.S1_3p_s_at
ILMN_1674838
ILMN_1719756
IPR000719
IPR000980
IPR001245
IPR008266
IPR011009
IPR012234
IPR017441
IPR020635
L05148
L05148_at
LRG_126
LRG_126t1
MIM:176947
NM_001079
NM_207519
NP_001070
NP_997402
OTTHUMP00000203013
OTTHUMP00000216626
PF00017
PF07714
PR00109
PR00401
R-HSA-1280218
R-HSA-168256
R-HSA-202403
R-HSA-202430
R-HSA-202433
SM00219
SM00252
uc002syd.2
uc002syf.2
UPI00000743CC
UPI000013C370
XM_005264015
XM_006712728
XM_011511783
XP_005264072
XP_006712791
XP_011510085
ZAP70
ZAP70-001
ZAP70-008
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:11000464] KEGG Gene:ZAP70 [Homo sapiens]
[ReferenceDNASequence:9579647] Orphanet:15738 [Homo sapiens]
[ReferenceDNASequence:9593107] NCBI Gene:7535 [Homo sapiens]
[ReferenceDNASequence:9617355] BioGPS Gene:7535 [Homo sapiens]
[ReferenceDNASequence:9641617] CTD Gene:7535 [Homo sapiens]
[ReferenceDNASequence:9665879] dbSNP Gene:7535 [Homo sapiens]
[ReferenceDNASequence:9689997] ENSEMBL:ENSG00000115085 [Homo sapiens]
referenceTranscript[ReferenceRNASequence:9822657] RefSeq:NM_001079
secondaryIdentifierZAP70_HUMAN
A6NFP4
Q6PIA4
Q8IXD6
Q9UBS6
sequenceLength619
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:202252] p-Y315,Y493-ZAP70 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:202368] p-Y493-ZAP70 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:202397] ZAP70 [cytosol] [Homo sapiens]
(referenceSequence)[ModifiedResidue:202313] O4'-phospho-L-tyrosine at 493
[ModifiedResidue:202409] O4'-phospho-L-tyrosine at 315