Reactome: A Curated Pathway Database
Results 1 to 10 of 29
Pathways (7) Reactions (11) Proteins (1) Others (10)
Protein: UniProt:P13224 GP1BB (Homo sapiens)
Last changed: 2014-11-25 09:29:35

Pathway: Hemostasis (Homo sapiens)
Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes p
Last changed: 2014-11-21 19:49:01

Pathway: Platelet Adhesion to exposed collagen (Homo sapiens)
Initiation of platelet adhesion is the first step in the formation of the platelet plug. Circulating platelets are arrested and subsequently activated by exposed collagen and vWF. It is not entirely clear which type of collagen is responsible for adhesion and activation; collagen types I and III are abundant in vascular epithelia but several other types incluing IV are present (Farndale 2006). Several
Last changed: 2014-11-21 06:36:34

Pathway: Platelet activation, signaling and aggregation (Homo sapiens)
Platelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the platelet membrane (Ruggeri 2002). Intracellular signaling reactions then enhance the adhesive and procoagulant properties of tethered platelets or of platelets circulating in the proximity. Once platelets have
Last changed: 2014-11-21 19:49:01

Pathway: Platelet Aggregation (Plug Formation) (Homo sapiens)
The tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment of others onto their surface leads to the formation of large platelet aggregates. The formation of a thrombus is strictly dependent on the formation of interplatelet bonds
Last changed: 2014-11-21 14:40:22

Pathway: GP1b-IX-V activation signalling (Homo sapiens)
The platelet GPIb complex (GP1b-IX-V) together with GPVI are primarily responsible for regulating the initial adhesion of platelets to the damaged blood vessel and platelet activation. The importance of GPIb is demonstrated by the bleeding problems in patients with Bernard-Soulier syndrome where this receptor is either absent or defective. GP1b-IX-V binds von Willebrand Factor (vWF) to resting platelet
Last changed: 2014-11-21 14:40:22

Pathway: Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
The formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to fibrin clot formation are commonly described as a cascade, in which the product of each step is an enzyme or cofactor needed for following reactions to proceed efficiently. The entire clotting cascade can
Last changed: 2014-11-21 19:49:01

Pathway: Intrinsic Pathway (Homo sapiens)
The intrinsic pathway of blood clotting connects interactions among kininogen (high molecular weight kininogen, HK), prekallikrein (PK), and factor XII to the activation of clotting factor X by a series of reactions that is independent of the extrinsic pathway and that is not subject to inhibition by TFPI. It is thus essential for the prolongation of the clotting cascade: while the reactions of the ext
Last changed: 2014-11-21 14:40:22

Reaction: Thrombin binding to GP1b:IX:V (Homo sapiens)
Thrombin binds to the GP1b-IX-V receptor during platelet aggregation. This leads to increased PAR activation, possibly due to favourable orientation of thrombin towards the PAR extracellular domain
Last changed: 2014-11-21 06:36:34

Reaction: GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)
The Gp1b-IX-V complex binds to 14-3-3-zeta, a scaffolding protein. The highly conserved cytoplasmic domain of GpIb alpha binds directly to dimeric 14-3-3 zeta adapter protein. Binding also involves regions of GpV, and is enhanced by phosphorylation of GP1b at Ser-609 or Ser-166 of Gp1b alpha and beta respectively. For Gp1b beta this phosphorylation is PKA-dependent
Last changed: 2014-11-21 06:36:34

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